arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2023-29-1-38-50arthyper-2257Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВозможности нового показателя START в оценке сосудистой жесткости у здоровых лицThe possibilities of the new START indicator in the assessment of vascular stiffness in healthy individualshttps://orcid.org/0000-0002-0963-4793СуминА. Н.SuminА. N.

Сумин Алексей Николаевич — доктор медицинских наук, заведующий лабораторией коморбидности при сердечно-сосудистых заболеваниях

Aleksey N. Sumin, MD, PhD, DSc, Head, Laboratory of Comorbidity in cardiovascular Diseases

an_sumin@mail.ruhttps://orcid.org/0000-0002-4108-164XЩегловаА. В.ShcheglovaA. V.

Щеглова Анна Викторовна — к.м.н., научный сотрудник лаборатории коморбидности при сердечно-сосудистых заболеваниях

Anna V. Shcheglova, MD, PhD, Researcher, Laboratory of Comorbidity in Cardiovascular Diseases

nura.karpovitch@yandex.ruhttps://orcid.org/0000-0003-0928-2430БахолдинИ. Б.BakholdinI. B.

Бахолдин Игорь Борисович — доктор физико-математических наук, старший научный сотрудник

Igor B. Bakholdin, Doctor of Physical and Mathematical Sciences, Senior Researcher

ibbakh@yandex.ruФедеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияResearch Institute of Complex Problems of Cardiovascular DiseasesRussian FederationФедеральное государственное учреждение «Федеральный исследовательский центр Институт прикладной математики имени М. В. Келдыша Российской академии наук»РоссияFederal Research Center Institute of Applied Mathematics named after M. V. Keldysh of the Russian Academy of SciencesRussian Federation2023190920222913850Copyright © Сумин А.Н., Щеглова А.В., Бахолдин И.Б., 20232023Сумин А.Н., Щеглова А.В., Бахолдин И.Б.Sumin А.N., Shcheglova A.V., Bakholdin I.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2257

Цель исследования — изучить возможность использования нового индекса артериальной жесткости START у здоровых лиц разного возраста. Материалы и методы. В исследование были включены данные здоровых лиц без каких-либо заболеваний в анамнезе (n = 190), 121 мужчина и 69 женщин в возрасте 25–64 лет. Всем обследуемым проводили оценку артериальной жесткости на аппарате VaSeraVS-1000 (Fukuda Denshi, Япония). В качестве дополнительного параметра ретроспективно был проанализирован новый отечественный индекс жесткости START. Результаты. Средний возраст участников составил 37,0 ± 8,1 года, 63,7 % мужчин. Медиана индекса CAVI составила справа — 6,6, слева — 6,7. Медиана индекса START 5,02 справа, 5,3 слева. Выявлена сильная взаимосвязь показателей CAVI и START (r = 0,829, р < 0,001). Установлена связь возраста с индексами CAVI и START (CAVI r = 0,469, р < 0,001, START r = 0,49, р < 0,001). Выявлена связь показателей жесткости сосудистой стенки со стажем курения (CAVI r = 0,458, р < 0,001, START r = 0,466, р < 0,001), скоростью клубочковой фильтрации (СКФ) (CAVI r = –0,265, р < 0,001, START r = –0,282, р < 0,001). Установлены гендерные особенности связи жесткости сосудистой стенки и уровня липопротеинов высокой плотности (ЛПВП) (у женщин CAVI r = 0,241, р = 0,048; START r = 0,358, р = 0,003) и индекса массы тела (ИМТ) (у женщин CAVI r = 0,411, р = 0,027, START r = 0,374, р = 0,046). Заключение. При обследовании здоровых лиц показана высокая корреляция нового индекса START с индексом CAVI как в целом по всей выборке, так и у мужчин, и у женщин по отдельности. Индекс START статистически значимо коррелировал с возрастом, стажем курения и СКФ среди всех обследованных, а также с ЛПВП и ИМТ у женщин.

Objective. To study the possibility of using the new arterial stiffness index START in healthy individuals of different ages. Design and methods. The study included data from healthy individuals without any medical history (n = 190), 121 men and 69 women aged 25–64 years. Arterial stiffness was assessed for all subjects on the VaSera VS-1000 device (Fukuda Denshi, Japan). As an additional parameter, the new domestic stiffness index START was analyzed retrospectively. Results. The average age of the participants was 37,0 ± 8,1 years, 63,7 % men. The median of the CAVI index was 6,6 on the right, 6,7 on the left. The median of the START index was 5,02 on the right, 5,3 on the left. A strong correlation between CAVI and START indicators was found (r = 0,829, p < 0,001). The relationship of age with the CAVI and START indices was established (CAVI r = 0,469, p < 0,001, START r = 0,49, p < 0,001). The dependence of vascular wall stiffness indicators on smoking experience (CAVI r = 0,458, p < 0,001, START r = 0,466, p < 0,001), glomerular filtration rate (GFR) (CAVI r = –0,265, p < 0,001, START r = –0,282, p < 0,001) was found. The gender features of the dependence of vascular wall stiffness on the level of high-density lipoproteins (HDL) (in women, CAVI r = 0,241, p = 0,048; START r = 0,358, p = 0,003) and body mass index (BMI) (in women, CAVI r = 0,411, p = 0,027, START r = 0,374, p = 0,046). Conclusions. When examining healthy individuals, a high correlation of the new START index with the CAVI index was shown both in the whole sample and in men and women separately. The START index had a statistically significant correlation with age, smoking experience and GFR among all surveyed, as well as with HDL and BMI in women.

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The authors declare that there are no conflicts of interest present.