arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2023-29-6-543-556BMYGAKarthyper-2310Research ArticleСтатьиArticlesАнгиотензин-превращающий фермент: хорошо знакомый незнакомец. Часть IIAngiotensin-converting enzyme: a well-known stranger. Part IIhttps://orcid.org/0000-0002-2665-9108НалесникЕ. О.NalesnikE. O.

Налесник Елена Олеговна — научный сотрудник

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Elena O. Nalesnik, Research Associate

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oliver@cardio-tomsk.ruНаучно-исследовательский институт кардиологии — филиал Федерального государственного бюджетного научного учреждения «Томский национальный исследовательский медицинский центр Российской академии наук»РоссияResearch Institute of Cardiology, Tomsk National Research Medical CenterRussian Federation202327022023296548556Copyright © Налесник Е.О., 20232023Налесник Е.О.Nalesnik E.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2310

Ангиотензинпревращающий фермент (АПФ) конститутивно экспрессируется на поверхности эндотелиальных, эпителиальных и клеток иммунной системы (макрофаги, дендритные клетки). Считается, что основным источником циркулирующего АПФ являются легкие. Однако было также обнаружено, что другие органы, такие как тонкая кишка, почки, сердце, головной мозг, придатки яичников, предстательная железа, имеют уровни экспрессии АПФ, сравнимые с таковыми в легких. Экспрессия АПФ регулируется не только пассивно, количеством эндотелиальных клеток, но и функцией эндотелия. В целом биохимическая среда является движущей силой ферментативной активности АПФ, воздействуя на клетки, способные экспрессировать АПФ и регулирующие белки. Открытие тканевого АПФ изменило наши представления о патофизиологии многих заболеваний. В частности, оказалось, что в развитии артериальной гипертензии, диабетической нефропатии, острой и хронической болезни почек большее значение имеет почечный АПФ, чем циркулирующий.

The angiotensin-converting enzyme (ACE) is constitutively expressed on the surface of endothelial, epithelial and immune system cells (macrophages, dendritic cells). The lungs are believed to be the main source of circulating ACE. However, other organs such as the small intestine, kidneys, heart, brain, epididymis, and prostate have also been found to express ACE at levels comparable to those in the lungs. ACE expression is regulated not only passively by the number of endothelial cells, but also by endothelial function. In general, the biochemical environment is the driving force behind the enzymatic activity of ACE, influencing cells capable of expressing ACE and regulatory proteins. The discovery of tissue ACE has changed our understanding of the pathophysiology of many diseases. In particular, it turned out that renal versus circulating ACE is more important in the development of arterial hypertension, diabetic nephropathy, acute and chronic kidney disease.

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The authors declare that there are no conflicts of interest present.