arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2023-29-4-342-352arthyper-2321Research ArticleСтатьиArticlesПоказатели центрального артериального давления и характеристики пульсовой волны при аневризме нисходящего грудного и брюшного отделов аорты: особенности, динамика и прогностическое значениеCentral aortic blood pressure and pulse wave characteristics in patients with decscending thoracic and abdominal aortic aneurysm: features, dynamics, and prognostic significancehttps://orcid.org/0000-0002-1489-3618ГуревичАлександра ПавловнаGurevichA. P.

младший научный сотрудник научно-исследовательской лаборатории патогенеза и терапии артериальной гипертензии научно-исследовательского отдела «Артериальная гипертензия»

Aleksandra P. Gurevich - MD, Junior Researcher, Department for Arterial Hypertension, Almazov National Medical Research Centre.

2 Akkuratov str., St Petersburg, 197341

Phone: 8 (812) 670–30–03 (ext. 005725)

gurevich_ap@almazovcentre.ruhttps://orcid.org/0000-0002-3176-0606ЕмельяновИгорь ВитальевичEmelyanovI. V.

кандидат медицинских наук, старший научный сотрудник научно-исследовательской лаборатории патогенеза и терапии артериальной гипертензии научно-исследовательского отдела «Артериальная гипертензия»

Igor V. Emelyanov - MD, PhD, Senior Researcher, Department for Arterial Hypertension, Department for Arterial Hypertension, Almazov National Medical Research Centre.

St Petersburg

emelyanov_iv@almazovcentre.ruhttps://orcid.org/0000-0002-3664-5383ИоновМихаил ВасильевичIonovM. V.

кандидат медицинских наук, научный сотрудник научно-исследовательской лаборатории патогенеза и терапии артериальной гипертензии научно-исследовательского отдела «Артериальная гипертензия»

Mikhail V. Ionov - MD, PhD, Researcher, Department for Arterial Hypertension, Department for Arterial Hypertension, Almazov National Medical Research Centre.

St Petersburg

ionov_mv@almazovcentre.ruhttps://orcid.org/0000-0002-8209-9993ВанюркинАлмаз ГафуровичVanyurkinA. G.

научный сотрудник научно-исследовательского отдела сосудистой и интервенционной хирургии

Almaz G. Vanyurkin - MD, Researcher, Department for Vascular and Interventional Surgery, Almazov National Medical Research Centre.

St Petersburg

vanyurkin_ag@almazovcentre.ruhttps://orcid.org/0000-0003-1214-0150ЧернявскийМихаил АлександровичChernyavskiyM. A.

доктор медицинских наук, заведующий научно-исследовательским отделом сосудистой и интервенционной хирургии

Mikhail A. Chernyavskiy - MD, PhD, DSc, Head, Department for Vascular and Interventional Surgery, Almazov National Medical Research Centre.

St Petersburg

chernyavskiy_ma@almazovcentre.ruhttps://orcid.org/0000-0001-8169-7812КонрадиАлександра ОлеговнаKonradiA. O.

доктор медицинских наук, профессор, академик Российской академии наук, заведующая кафедрой организации, управления и экономики здравоохранения Института медицинского образования, заместитель генерального директора по научной работе

Aleksandra O. Konradi - MD, PhD, DSc, Professor, Academician of the Russian Academy of Sciences, Head, Department for Arterial Hypertension, Head, Department of Organization, Management and Economics of Healthcare, Institute of Medical Education, Deputy General Director on Research, Almazov National Medical Research Centre.

St Petersburg

konradi_ao@almazovcentre.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian Federation202317042023294342352Copyright © Гуревич А.П., Емельянов И.В., Ионов М.В., Ванюркин А.Г., Чернявский М.А., Конради А.О., 20232023Гуревич А.П., Емельянов И.В., Ионов М.В., Ванюркин А.Г., Чернявский М.А., Конради А.О.Gurevich A.P., Emelyanov I.V., Ionov M.V., Vanyurkin A.G., Chernyavskiy M.A., Konradi A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2321

Аневризма аорты (АА) является одним из наиболее грозных сердечно-сосудистых заболеваний, отличающихся сочетанием малозаметных клинических проявлений и высоким риском осложнений. Предрасполагающие факторы развития АА — возраст, артериальная гипертензия (АГ), атеросклероз, воспалительные заболевания аорты — ассоциированы с изменениями сосудистой жесткости. АГ вызывает повышенное напряжение стенки аорты при подъеме пульсовой волны артериального давления (АД)    у пациентов с АА. Особый интерес представляют показатели центрального АД и сосудистой жесткости, являющиеся независимыми факторами риска сердечно-сосудистых событий, но малоизученные именно среди пациентов с АА. Цель обзора — суммировать представления о взаимосвязях АА с показателями сосудистой жесткости, центральной гемодинамики у пациентов с неоперированной АА, а также после эндоваскулярной изоляции АА. Обсуждены прогностическая точность и применимость отдельных маркеров в отношении прогрессирования АА и исходов оперативного лечения, определены нерешенные вопросы и перспективы дальнейших исследований.

Aortic aneurysm (AA) is one of the most formidable cardiovascular diseases, characterized by subtle clinical manifestations and a high risk of complications. Predisposing factors in the development of AA are age, arterial hypertension (HTN), atherosclerosis, and inflammatory aortic diseases. Those are associated with changes in vascular stiffness. HTN causes increased tension in the aortic wall when the pulse wave of blood pressure (BP) rises in patients with AA. Indicators of central BP and vascular stiffness are of particular interest. They present as independent risk factors for cardiovascular events but are poorly studied among patients with AA. The purpose of the review is to summarize the ideas about the relationship of AA with the indicators of vascular stiffness and central hemodynamics in patients with non-operated AA, as well as after endovascular AA repair. Here we discuss the predictive accuracy and applicability of individual markers concerning AA progression and surgical treatment outcomes, as well as unresolved issues and prospects for further research.

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The authors declare that there are no conflicts of interest present.