arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2025-2335UUBMMQarthyper-2335Research ArticleСтатьиArticlesПоказатели функции печени при артериальной гипертензии (обзор литературы)Liver Function Tests in Hypertension: a Literature ReviewРафакатСайраRafaqatSaira

Рафакат Сайра — доктор наук,

Лахор.

Saira Rafaqat, PhD (Scholar), Department of Zoology,

Lahore.

saera.rafaqat@gmail.comАршадА.ArshadA.

Аршад Амбер,

Лахор.

Amber Arshad, Department of Zoology,

Lahore.

amberarshadchodhry97@gmail.comНошарИ.NoshairI.

Ношар Икра,

Лахор.

Iqra Noshair, PhD (Scholar), Department of Zoology,

Lahore.

iqra.noshair@lcwu.edu.pkКуршидХ.KhurshidH.

Куршид Хума — доктор наук, 

Лахор.

Huma Khurshid, PhD (Scholar), Department of Zoology, 

Lahore.

huma.khurshid@lcwu.edu.pkРафакатСанаRafaqatSana

Рафакат Сана — доктор наук, 

Лахор.

Sana Rafaqat, Ph.D. (Scholar), Department of Biotechnology, 

Lahore.

sana.rafaqat44@gmail.comЛахорский колледж женского университетаПакистанLahore College for Women UniversityPakistan2025290520253116376Copyright © Рафакат С., Аршад А., Ношар И., Куршид Х., Рафакат С., 20252025Рафакат С., Аршад А., Ношар И., Куршид Х., Рафакат С.Rafaqat S., Arshad A., Noshair I., Khurshid H., Rafaqat S.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2335

Актуальность. У лиц с артериальной гипертензией (АГ) регистрируются более высокие маркеры функции печени, а также при повышенных показателях функции печени отмечается более высокий риск АГ. Нарушение функции печени рассматривается как фактор, способствующий развитию АГ. Цель исследования. В статье особое внимание уделено таким показателям функции печени, как альбумин, щелочная фосфатаза (ЩФ), аланинаминотрансфераза (АЛТ), аспартатаминотрансфераза (АСТ), гамма-глутамилтранспептидаза (ГГТП), сывороточный билирубин, лактатдегидрогеназа (ЛДГ), протромбиновое время (ПВ), и их роли при АГ. Результаты. Повышение уровня альбумина от 40 до 50 г/л в пределах физиологических колебаний коррелирует с повышением систолического артериального давления на 5–11 мм рт. ст. у мужчин и на 6–17 мм рт. ст. у женщин. Также показана отрицательная связь между сывороточным уровнем ЩФ и показателями анатомии и функции артерий у африканцев. Обратная связь выявлена между уровнем АЛТ и АГ во взрослой китайской когорте, что дает основания предположить, что повышение уровня АЛТ может предшествовать развитию АГ. В целом встречаемость повышенного уровня АЛТ и АСТ среди первокурсников составила 6,8 % и 2,3 % соответственно. Повышение уровня ГГТП ассоциировано с увеличением риска АГ. У мужчин с предгипертензией (но не у нормотензивных лиц) уровень билирубина в сыворотке крови отрицательно коррелировал с показателями жесткости артерий. У женщин такой связи выявлено не было. Повышение уровня ЛДГ в сыворотке крови было ассоциировано с АГ беременных и развитием осложнений как со стороны матери, так и со стороны плода. Систолическое и диастолическое артериальное давление положительно коррелировало с активированным частичным тромбопластиновым временем (АЧТВ) у лиц с АГ. Можно предположить, что ПВ и АЧТВ могут использоваться как показатели нарушений в системе свертывания крови у лиц с АГ для коррекции терапии. Конкретные механизмы, через которые печеночные маркеры влияют на уровень артериального давления и риск АГ, до конца неясны.

Background. Individuals with hypertension tend to have higher liver function test (LFT) levels and an increased risk of hypertension when abnormal LFT levels are present. The dysfunction of the liver is identified as a significant contributor to the development of hypertension. Objective. The article specifically focuses on review of various LFT markers such as albumin, alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), serum bilirubin, lactate dehydrogenase, prothrombin time (PT) and their role in hypertension. Results. The increase in albumin concentration from approximately 40 to 50 g/l within the physiological range correlated with a rise in systolic blood pressure ranging from 5 to 11 mmHg in males and from 6 to 17 mmHg in females. Also, there is a negative correlation between serum ALP and indices of artery anatomy and function in hypertensive African men. Moreover, an inverse correlation between elevated ALT levels and hypertension in Chinese adults, suggesting that elevated ALT may precede the onset of hypertension. The overall prevalence of elevated ALT and AST among freshmen was 6,8 % and 2,3 %, respectively, suggesting a strong correlation between ALT levels and hypertension in both males and females. Another study indicated that higher GGT levels were associated with an increased risk of hypertension. In men with pre-hypertension, but not in normotensive individuals, serum bilirubin levels negatively correlated with arterial stiffness. No significant relationship between arterial stiffness and bilirubin levels was observed in women. An increase in serum LDH level is linked to the severity of pregnancy-induced hypertension and complications for both mother and fetus. Systolic blood pressure and diastolic blood pressure showed a positive correlation with activated partial thromboplastin time (APPT) in hypertensive patients. These findings suggest that PT and APTT measurements could be used as indicators to assess hemostatic abnormalities in individuals with hypertension and guide antihypertensive medication. The exact mechanisms by which the liver function panel influences hypertension were not reported.

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The authors declare that there are no conflicts of interest present.