arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2024-2427JQUKMDarthyper-2427Research ArticleСтатьиArticlesРенин-ангиотензиновая система и центральная регуляция кровообращенияRenin-angiotensin system and central regulation of blood circulationhttps://orcid.org/0000-0002-7767-8560ЦырлинВ. А.TsyrlinV. A.

Цырлин Виталий Александрович — доктор медицинских наук, главный научный сотрудник отдела экспериментальной физиологии и фармакологии ФГБУ «НМИЦ им. В.А. Алмазова» Минздрава России.

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Vitaliy A. Tsyrlin - MD, PhD, DSc, Professor, Chief Researcher, Department of Experimental Physiology and Pharmacology of Preclinical and Translational Research Centre, Almazov National Medical Research Centre.

2 Akkuratov str., St Petersburg, 197341

tsyrlinva@mail.ruhttps://orcid.org/0000-0001-6027-7325КузьменкоН. В.KuzmenkoN. V.

Кузьменко Наталия Владимировна — кандидат биологических наук, старший научный сотрудник отдела экспериментальной физиологии и фармакологии ФГБУ «НМИЦ им. В.А. Алмазова» Минздрава России; младший научный сотрудник лаборатории экспериментальных исследований Центра лазерной медицины ФГБОУ ВО ПСПбГМУ им. акад. И.П. Павлова Минздрава России.

Санкт-Петербург

Nataliya V. Kuzmenko - PhD in Biology, Senior Researcher, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre, Almazov National Medical Research Centre; Researcher of Experimental Research Laboratories of the Laser Medicine Center, Pavlov First Saint Petersburg State Medical University.

St Petersburg

nat.kuzmencko2011@yandex.ruhttps://orcid.org/0000-0002-1515-1616ПлиссМ. Г.PlissM. G.

Плисс Михаил Гениевич — кандидат медицинских наук, заведующий отделом экспериментальной физиологии и фармакологии ФГБУ «НМИЦ им. В.А. Алмазова» Минздрава России.

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Mikhail G. Pliss - PhD, Head, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre, Almazov National Medical Research Centre.

2 Akkuratov str., St Petersburg, 197341

pliss@niiekf.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical UniversityRussian Federation202414062024304373381Copyright © Цырлин В.А., Кузьменко Н.В., Плисс М.Г., 20242024Цырлин В.А., Кузьменко Н.В., Плисс М.Г.Tsyrlin V.A., Kuzmenko N.V., Pliss M.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2427

В статье представлены характеристика ангиотензиновых рецепторов нейронов центральной нервной системы, механизмы проникновения и образования ангиотензина в мозге, влияние ангиотензина II на нейроны различных ядер мозга, принимающих участие в регуляции кровообращения. Отмечена способность блокаторов ангиотензиновых рецепторов проникать через гематоэнцефалический барьер и оказывать центральный эффект. Рассматриваются перспективы использования ангиотензинов (1–7) и (1–9) в терапии артериальной гипертензии.

The article presents the characteristics of angiotensin receptors of the central nervous system neurons, the mechanisms of penetration and formation of angiotensin in the brain, the effect of angiotensin II on neurons of various nuclei of the brain involved in the regulation of blood circulation. The ability of angiotensin receptor blockers to penetrate the blood-brain barrier and have a central effect was noted. The prospects for the use of angiotensins (1–7) and (1–9) in the treatment of hypertension are considered.

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The authors declare that there are no conflicts of interest present.