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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2025-2450</article-id><article-id custom-type="edn" pub-id-type="custom">XKZNKR</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-2450</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Связь между центральным аортальным давлением и диастолической функцией у пациентов, подвергающихся коронарной ангиографии</article-title><trans-title-group xml:lang="en"><trans-title>Association between central aortic pressure and diastolic function in patients undergoing coronary angiography</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7744-2857</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самант</surname><given-names>Дж.</given-names></name><name name-style="western" xml:lang="en"><surname>Samanth</surname><given-names>J.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Самант Джоти - доцент, отдел сердечно-сосудистых технологий,</p><p>Манипал</p></bio><bio xml:lang="en"><p>Jyothi Samanth - MD, PhD, Associate Professor, Department of Cardiovascular Technology,</p><p>Manipal</p></bio><email xlink:type="simple">samanth.jyothi@manipal.edu</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рао</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Rao</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рао М. Судхакар  - кардиолог, отделение кардиологии,</p><p>Бангалор, Карнатака</p></bio><bio xml:lang="en"><p>Rao M. Sudhakar - MD, Consultant Cardiologist, Department of Cardiology, </p><p>Karnataka</p></bio><email xlink:type="simple">msudhakar88@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наяк</surname><given-names>K.</given-names></name><name name-style="western" xml:lang="en"><surname>Nayak</surname><given-names>K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наяк Кришнананда - доцент, отдел сердечно-сосудистых технологий,</p><p>Манипал</p></bio><bio xml:lang="en"><p>Krishnananda Nayak - MD, PhD, Associate Professor, Department of Cardiovascular technology,</p><p>Manipal</p></bio><email xlink:type="simple">krishnananda.n@manipal.edu</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сундар</surname><given-names>С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sundar</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Споорти Сундар - интерн, отдел сердечно-сосудистых технологий,</p><p>Манипал</p></bio><bio xml:lang="en"><p>Spoorthi Sundar -, MD, BSc, Intern, Department of Cardiovascular technology, </p><p>Manipal</p></bio><email xlink:type="simple">spoorthisundar1998@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джордж</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>George</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джордж К.С. - интерн, отдел сердечно-сосудистых технологий,</p><p>Манипал</p></bio><bio xml:lang="en"><p>K.S. George - MD, BSc, Intern, Department of Cardiovascular technology,</p><p>Manipal</p></bio><email xlink:type="simple">georgepious1294@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джоз</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Jose</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джоз Алка Мария - интерн, отдел сердечно-сосудистых технологий,</p><p>Манипал</p></bio><bio xml:lang="en"><p>Alka Mariya Jose - MD, BSc, Intern, Department of Cardiovascular technology, </p><p>Manipal </p></bio><email xlink:type="simple">alkamariyajose@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рамахандран</surname><given-names>П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ramachandran</surname><given-names>P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рамахандран Падмакумар - профессор, отделение кардиологии,</p><p>Манипал</p></bio><bio xml:lang="en"><p>Padmakumar Ramachandran - MD, PhD, DM, Professor, Department of Cardiology, </p><p>Manipal</p></bio><email xlink:type="simple">Padmakumar69@yahoo.co.in</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наик</surname><given-names>К.</given-names></name><name name-style="western" xml:lang="en"><surname>Naik</surname><given-names>K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наик Картик - доцент, отдел сердечно-сосудистых технологий,</p><p>Манипал</p></bio><bio xml:lang="en"><p>Karthik Naik - MD, MSc, Assistant Professor, Department of Cardiovascular technology,</p><p>Manipal </p></bio><email xlink:type="simple">naik.karthik@manipal.edu</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Колледж смежных медицинских профессий Манипал, Академия высшего образования Манипал</institution><country>Индия</country></aff><aff xml:lang="en"><institution>Manipal College of Health Professions, Manipal Academy of Higher Education</institution><country>India</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Больница Манипал</institution><country>Индия</country></aff><aff xml:lang="en"><institution>Manipal Hospital, Bangalore</institution><country>India</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Медицинский университет Касчерба, Академия высшего образования Манипал</institution><country>Индия</country></aff><aff xml:lang="en"><institution>Kasturba Medical College, Manipal Academy of Higher Education</institution><country>India</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>02</day><month>03</month><year>2026</year></pub-date><volume>31</volume><issue>6</issue><fpage>586</fpage><lpage>597</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Самант Д., Рао М.С., Наяк K., Сундар С., Джордж К.С., Джоз А.М., Рамахандран П., Наик К., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Самант Д., Рао М.С., Наяк K., Сундар С., Джордж К.С., Джоз А.М., Рамахандран П., Наик К.</copyright-holder><copyright-holder xml:lang="en">Samanth J., Rao M.S., Nayak K., Sundar S., George K.S., Jose A.M., Ramachandran P., Naik K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/2450">https://htn.almazovcentre.ru/jour/article/view/2450</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Колебания давления в аорте вносят существенный вклад в развитие атеросклероза, а ремоделирование сосудистой стенки, включая изменение артериальной жесткости, ассоциировано с сердечно-сосудистой заболеваемостью и смертностью. Колебания центрального артериального давления и его производных также влияют на ремоделирование миокарда и изменение его функции.</p><p>Цель исследования — оценка взаимосвязей между уровнем центрального давления в аорте, измеренного инвазивным способом, и его производными, а также между состоянием диастолической функции левого желудочка (ЛЖ) и его скручиванием (торсией).</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В проспективное исследование было включено 90 пациентов с сохраненной функцией ЛЖ, направленных на выполнение коронарной ангиографии.</p></sec><sec><title>Результаты</title><p>Результаты. Выявлены значимые линейные взаимосвязи между эхокардиографическими показателями, отражающими диастолическую функцию ЛЖ, такими как индекс объема левого предсердия (ИОЛП), соотношение E/еʼ ЛЖ (соотношение между скоростью раннего диастолического наполнения ЛЖ и ранней диастолической скоростью движения кольца митрального клапана), и центральным давлением в аорте. Поворот ЛЖ по оси (твист — от англ. twist) не коррелировал с показателями центрального давления в аорте. Только у 15 из 90 пациентов выявлена диастолическая дисфункция ЛЖ 2-й степени и выше со средним показателем поворота ЛЖ по оси 19,65 ± 9,4 против 16,70 ± 8,6 градуса при нормальном конечно-диастолическом давлении (p = 0,206). Это различие оказалось статистически значимым, отражая тот факт, что увеличение поворота ЛЖ по оси является доминирующим признаком у пациентов с высокой степенью диастолической дисфункции ЛЖ независимо от массы ЛЖ.</p></sec><sec><title>Заключение</title><p>Заключение. Мы установили взаимосвязь между центральным давлением в аорте и состоянием диастолической функции ЛЖ. Несмотря на нормальную фракцию выброса ЛЖ у всех обследованных, поворот ЛЖ по оси был увеличен у пациентов с диастолической дисфункцией ЛЖ 2-й степени и выше.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Aortic pressure dynamics significantly affect the development of arteriosclerosis, and chronic changes in the aortic wall, including surface stiffness, are strongly associated with cardiovascular mortality and morbidity. Variations in central aortic pressure and its derivatives have an impact on myocardial structural remodeling and function.</p><p>This study aimed to determine the associations between invasively measured central aortic pressure and its derivatives and between left ventricular (LV) diastolic function status and torsion.</p></sec><sec><title>Design and methods</title><p>Design and methods. This prospective study included 90 participants with normal LV function who were referred for elective coronary angiography.</p></sec><sec><title>Results</title><p>Results. There was a significant linear correlation between echocardiographic parameters reflecting LV diastolic function, such as the left atrial volume index (LAVI), the LV E/еʼ (ratio between mitral early diastolic velocity and early diastolic tissue annular velocity), and central aortic pressure. LV twist did not correlate with central aortic pressure parameters. Only 15 patients out of 90 had LV diastolic dysfunction of grade 2 and above, with a mean LV twist of 19,65 ± 9,4 vs 16,70 ± 8,6 degrees, as determined by normal LV end-diastolic pressure (p = 0,206). This difference appears clinically significant, illustrating that the increase in LV twist is predominant in patients with higher grades of LV diastolic dysfunction, irrespective of LV mass.</p></sec><sec><title>Conclusion</title><p>Conclusion. There was a relationship and interaction between central aortic pressure and LV diastolic function status. Despite all participants had normal LV ejection fraction, LV twist appeared to be increased among the patients with LV diastolic dysfunction of grade 2 or above.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>центральное давление в аорте</kwd><kwd>диастолическая дисфункция</kwd><kwd>скручивание левого желудочка</kwd><kwd>поворот по оси левого желудочка</kwd><kwd>торсия и твист левого желудочка</kwd><kwd>конечно-диастолическое давление левого желудочка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>central aortic pressure</kwd><kwd>diastolic dysfunction</kwd><kwd>left ventricular torsion</kwd><kwd>left ventricular twist</kwd><kwd>left ventricular end diastolic pressure</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The study was approved by the institutional ethics committee and registered in the Clinical trial registry of India (CTRI/2020/01/022756 dated 14/01/2020).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ichikawa K, Sakuragi S, Nishihara T, Tsuji M, Mori A, Yokohama F, et al. 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