arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2025-2480VELVEMarthyper-2480Research ArticleСтатьиArticlesУровень внеклеточной ДНК плода, циркулирующей в сыворотке крови матери, как предиктор преэклампсииCirculating Maternal Serum Cell Free Fetal DNA Levels for Prediction of Preeclampsiahttps://orcid.org/0009-0001-3889-8843НассарС. А.М.NassarS. A.M.

Нассар Салма Ашраф Мохаммед — преподаватель кафедры акушерства и гинекологии, медицинский факультет 

Salma Ashraf Mohamed Nassar, MD, Lecturer of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine,

Cairo

salmaashraf@med.asu.edu.eghttps://orcid.org/0000-0003-1124-9496Эль ДинА. М.Б.El DinA. M.B.

Эль Дин Ахмед Мохаммед Бахаа — доктор медицинских наук, профессор кафедры акушерства и гинекологии, медицинский факультет,

Каир.

Ahmed Mohamed Bahaa El Din, MD, PhD, DSc, Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine,

Cairo.

abahaa0503@med.ASU.edu.eghttps://orcid.org/0000-0001-8944-5564ИбрагимМ. Е.М.IbrahimM. E.M.

Ибрагим Мохаммед Эль Мандух Мохаммед — доктор медицинских наук, профессор кафедры акушерства и гинекологии, медицинский факультет,

Каир.

Mohamed El Mandouh Mohamed Ibrahim, MD, PhD, DSc, Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine,

Cairo.

mandooh@hotmail.comhttps://orcid.org/0009-0005-6239-5559ХельмиМ. М.М.HelmyM. M.M.

Мохаммед Махмуд Мохаммед Хельми — сотрудник кафедры акушерства и гинекологии, медицинский факультет,

Каир.

Mohamed Mahmoud Mohamed Helmy, MD, Department of Obstetrics and Gynecology, Faculty of Medicine,

Cairo.

m.m.helmy249@gmail.comhttps://orcid.org/0009-0009-1577-0140ЭлсвефиМ. С.ElsewefyM. S.

Элсвефи Мохаммед Самех — преподаватель кафедры акушерства и гинекологии, медицинский факультет,

Каир.

Mohamed Sameh Elsewefy, MD, Lecturer of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine,

Cairo.

melsewefy@med.asu.edu.egУниверситет Айн-ШамсЕгипетAin Shams UniversityEgypt2025290520253115462Copyright © Нассар С.А., Эль Дин А.М., Ибрагим М.Е., Хельми М.М., Элсвефи М.С., 20252025Нассар С.А., Эль Дин А.М., Ибрагим М.Е., Хельми М.М., Элсвефи М.С.Nassar S.A., El Din A.M., Ibrahim M.E., Helmy M.M., Elsewefy M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2480

Цель исследования — измерить уровень внеклеточной ДНК плода (вкДНКп), циркулирующей в сыворотке крови матери, и определить связь между уровнем вкДНКп в сыворотке матери и преэклампсией (ПЭ). Материалы и методы. В исследование типа случай-контроль включены 30 женщин с ПЭ и 30 сопоставимых здоровых беременных (контроль) в возрасте 18–40 лет. У всех обследуемых был один живой плод на сроке более 20 недель гестации. При включении в исследование у всех женщин были взяты образцы крови для определения уровня вкДНКп. Результаты. Уровень вкДНКп значительно отличался у женщин с ПЭ и женщин контрольной группы, более высокие уровни выявлены у женщин с ПЭ. Кроме того, уровень вкДНКп в материнской крови обладал предсказательной ценностью в отношении ПЭ (площадь под кривой 0,979). Заключение. Уровень вкДНКп в материнской крови может использоваться для оценки риска развития ПЭ. Средние уровни вкДНКп в сыворотке крови матери коррелируют с развитием осложнений у матери.

Objective. To measure the maternal serum cell free fetal DNA (CFFDNA) and establish the relationship between preeclampsia (PE) and maternal serum (CFFDNA) levels. Design and methods. A nested case-control study was carried out on 30 (PE) subjects and 30 matched controls aged 18–40 years old who were submitted at the Ain-S hams University maternity hospital. All subjects had a single viable fetus beyond 20-week gestational age. Upon enrollment, blood samples were collected, and the CFFDNA was subsequently measured in subjects and controls. Results. The CFFDNA level differed significantly between the analyzed groups, showing higher levels in PE diagnosed individuals than in controls. Additionally, the maternal serum CFFDNA level, utilizing an area under the curve of 0,979, predicted PE. Conclusion. Maternal serum cell free DNA can be utilized for PE prediction. The mean levels of CFFDNA correlate with developing maternal complications in PE.

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The authors declare that there are no conflicts of interest present.