arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2025-2485KGRDTWarthyper-2485Research ArticleСтатьиArticlesДенервация почек в терапии экспериментальной гипертензии у крыс с повышенной чувствительностью к поваренной соли (метаанализ литературных источников)Renal denervation in the therapy of experimental hypertension in rats with increased sensitivity to NaCl (meta-analysis)https://orcid.org/0000-0001-6027-7325КузьменкоН. В.KuzmenkoN. V.

Кузьменко Наталия Владимировна — кандидат биологических наук, старший научный сотрудник отдела экспериментальной физиологии и фармакологии ФГБУ «НМИЦ им. В.А. Алмазова» Минздрава России; младший научный сотрудник лаборатории экспериментальных исследований Центра лазерной медицины ФГБОУ ВО ПСПбГМУ им. акад. И.П. Павлова Минздрава России.

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Nataliya V. Kuzmenko - PhD in Biology, Senior Researcher, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre, Almazov National Medical Research Centre; Researcher of Experimental Research Laboratories of the Laser Medicine Center, Pavlov First Saint Petersburg State Medical University.

2 Akkuratov str., St Petersburg, 197341

nat.kuzmencko2011@yandex.ruhttps://orcid.org/0000-0002-1515-1616ПлиссМ. Г.PlissM. G.

Плисс Михаил Гениевич — кандидат медицинских наук, заведующий отделом экспериментальной физиологии и фармакологии ФГБУ «НМИЦ им. В.А. Алмазова» Минздрава России.

Санкт-Петербург

Mikhail G. Pliss - PhD, Head, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre, Almazov National Medical Research Centre, Head, Biophysics of Blood Circulation Laboratory, Research Educational Institute of Biomedicine, Pavlov University.

St Petersburg

pliss@niiekf.ruhttps://orcid.org/0000-0002-7767-8560ЦырлинВ. А.TsyrlinV. A.

Цырлин Виталий Александрович — доктор медицинских наук, профессор, главный научный сотрудник отдела экспериментальной физиологии и фармакологии ФГБУ «НМИЦ им. В.А. Алмазова» Минздрава России.

Санкт-Петербург

Vitaliy A. Tsyrlin - MD, PhD, DSc, Professor, Chief Researcher, Department of Experimental Physiology and Pharmacology of Preclinical and Translational Research Centre, Almazov National Medical Research Centre.

St Petersburg

tsyrlinva@mail.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical UniversityRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian Federation20250508202531298114Copyright © Кузьменко Н.В., Плисс М.Г., Цырлин В.А., 20252025Кузьменко Н.В., Плисс М.Г., Цырлин В.А.Kuzmenko N.V., Pliss M.G., Tsyrlin V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2485

Высокое содержание NaCl в пище способствует гиперволемии и росту артериального давления (АД). Чувствительность к NaCl была обнаружена у 26 % нормотензивной популяции людей и у 51 % гипертензивных пациентов. Цель работы — оценить с помощью метаанализа влияние денервации почек (ДП) на уровень АД у нормотензивных и гипертензивных солечувствительных крыс (Dahl-S и DOCA), потребляющих диету, обогащенную NaCl. Материалы и методы. Для метаанализа было отобрано 8 работ, в которых исследовались нормотензивные животные без указания повышенной чувствительности к соли, в 9 работах были использованы крысы линии Dahl-S (генетические аномалии ассоциированы с обширным повреждением почек и ростом АД при высокосолевой диете), в 12 работах — крысы с моделью DOCA (введение дезоксикортикостерона ацетата нормотензивным крысам вызывает гиперволемию и рост АД при высокосолевой диете). Результаты. Высокосолевая диета вызывала развитие выраженной гипертензии у крыс линии Dahl-S даже при наличии двух почек и у DOCA крыс с одной почкой. По результатам метаанализа, тотальная двусторонняя ДП снижала уровень АД на 3–6 % у нормотензивных, Dahl-S и DOCA крыс с двумя почками, содержащимися на высокосолевой диете. Максимальный гипотензивный эффект ДП (9–12 %) наблюдался у однопочечных крыс с DOCA-солевой гипертензией. ДП не уменьшала синдром «белого халата» в исследованных моделях, однако окончательный вывод о влиянии ДП на АД при эмоциональном стрессе сделать невозможно из-за разницы экспериментальных методик и малого количества исследований с использованием телеметрического измерения АД. Предварительная ДП существенно тормозила развитие DOCА-солевой, но не Dahl-S гипертензии. У нормотензивных животных и у крыс линии Dahl-S эффект ДП не зависел от продолжительности высокосолевой диеты. Чем дольше продолжалась DOCA-солевая гипертензия до ДП, тем меньше был антигипертензивный эффект ДП. У Dahl-S крыс первые 3 недели после ДП экскреция натрия уменьшалась, а через 4–6 недель увеличивалась. При этом нет достаточных доказательств изменения после ДП экскреции натрия у крыс с DOCA-солевой гипертензией. Выводы. При высокосолевой диете у нормотензивных крыс и у животных с солечувствительной гипертензией тотальная ДП снижает базовый уровень АД. Антигипертензивный эффект тотальной ДП больше у DOCA-крыс по сравнению с крысами линии Dahl-S, содержащимися на высокосолевой диете.

High NaCl content in food promotes hypervolemia and increased blood pressure (BP). Sensitivity to NaCl was found in 26 % of normotensive human population and in 51 % of hypertensive patients. The aim of the work was to evaluate the impact of renal denervation (RD) on BP in normotensive and hypertensive salt-sensitive rats (Dahl-S and DOCA) consuming a diet enriched with NaCl using meta-analysis. Materials and methods. The meta-analysis included eight studies, which investigated normotensive animals without indicating increased sensitivity to salt, 9 studies which used Dahl-S rats (genetic abnormalities are associated with extensive kidney damage and increased BP with a high-salt diet), and 12 studies which assessed rats with the DOCA model (administration of deoxycorticosterone acetate to normotensive rats causes hypervolemia and increased BP with a high-salt diet). Results. High-salt diet induced severe hypertension in Dahl-S rats even with two kidneys and in DOCA rats with one kidney. According to the results of meta-analysis, total bilateral RD decreased BP by 3–6 % in normotensive, Dahl-S and DOCA rats with two kidneys kept on a high-salt diet. The maximum hypotensive effect of RD (9–12 %) was observed in one-kidney rats with DOCA-salt hypertension. RD did not reduce the “white coat” syndrome in the studied models, but the final conclusion about the effect of RD on BP during emotional stress cannot be made due to the difference in experimental methods and the small number of studies using telemetric BP measurement. Preliminary RD significantly inhibited the development of DOCA-salt, but not Dahl-S hypertension. In normotensive animals and in Dahl-S rats, the RD effect did not depend on the duration of the high-salt diet. The longer DOCA-salt hypertension lasted before RD, the lesser the antihypertensive effect of RD. In Dahl-S rats, sodium excretion decreased during the first 3 weeks after RD, and increased after 4–6 weeks. However, there is no convincing evidence of changes in sodium excretion after RD in rats with DOCA-salt hypertension. Conclusions. With a high-salt diet in normotensive rats and in animals with salt-sensitive hypertension, total RD reduces the baseline BP level. The antihypertensive effect of total RD is greater in DOCA rats compared to Dahl-S rats kept on a high-salt diet.

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The authors declare that there are no conflicts of interest present.