arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2025-2515BIGWIEarthyper-2515Research ArticleСтатьиArticlesМикровезикулы при ишемическом инсульте (обзор)Microvesicles in ischemic strokehttps://orcid.org/0009-0008-5959-388XБражниковМ. В.BrazhnikovM. V.

Бражников Максим Владимирович — врач-невролог, 

Уфа.

Maksim V. Brazhnikov, MD, Neurologist, 

Ufa.

trextmm@gmail.comhttps://orcid.org/0000-0003-1001-2024КутлубаевМ. А.KutlubaevM. A.

Кутлубаев Мансур Амирович — доктор медицинских наук, доцент, заведующий кафедрой неврологии,

ул. Ленина, д. 3, Уфа, 450008.

Mansur A. Kutlubaev, MD, PhD, DSc, Associate Professor, Head, Department of Neurology,

3 Lenin str., Ufa, 450008.

mansur.kutlubaev@yahoo.comhttps://orcid.org/0000-0001-9683-3012МустафинИ. Г.MustafinI. G.

Мустафин Ильшат Ганиевич — доктор медицинских наук, профессор, заведующий кафедрой биохимии, 

Казань.

Ilshat G. Mustafin, MD, PhD, DSc, Professor, Head, Department of Biochemistry, 

Kazan.

ilshat64@mail.ruhttps://orcid.org/0000-0002-4558-6119ГалиуллинТ. Р.GaliullinT. R.

Галиуллин Тимур Рифович — кандидат медицинских наук, заведующий отделением неврологии с функцией РСЦ,

Уфа.

Timur R. Galiullin, MD, PhD, Head, Division of Neurology with the function of RVC, 

Ufa.

trgaliullin@mail.ruhttps://orcid.org/0000-0001-9302-499XСамородовА. В.SamorodovA. V.

Самородов Александр Владимирович — доктор медицинских наук, профессор, заведующий кафедрой фармакологии,

Уфа.

Alexander V. Samorodov, MD, PhD, DSc, Professor, Head, Department of Pharmacology, 

Ufa.

avsamorodov@gmail.comГосударственное бюджетное учреждение здравоохранения Республики Башкортостан «Республиканская клиническая больница им. Г. Г. Куватова»РоссияRepublican Clinical Hospital named after G. G. KuvatovRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Башкирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияBashkir State Medical UniversityRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Казанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKazan State Medical UniversityRussian FederationГосударственное бюджетное учреждение здравоохранения Республики Башкортостан «Республиканская клиническая больница им. Г. Г. Куватова»; Федеральное государственное бюджетное образовательное учреждение высшего образования «Башкирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияRepublican Clinical Hospital named after G. G. Kuvatov; Bashkir State Medical UniversityRussian Federation202530012026315393402Copyright © Бражников М.В., Кутлубаев М.А., Мустафин И.Г., Галиуллин Т.Р., Самородов А.В., 20262026Бражников М.В., Кутлубаев М.А., Мустафин И.Г., Галиуллин Т.Р., Самородов А.В.Brazhnikov M.V., Kutlubaev M.A., Mustafin I.G., Galiullin T.R., Samorodov A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/2515

В настоящее время идет активное изучение микровезикул периферической крови у пациентов с ишемическим инсультом. Большинство исследований указывают на увеличение уровня циркулирующих микровезикул в различные периоды инсульта. Имеющиеся данные позволяют рассматривать уровень микровезикул в качестве потенциального биомаркера атеротромботического подтипа ишемического инсульта. Тяжесть инсульта, объем поражения головного мозга, а также его исход коррелируют с уровнем микровезикул в периферической крови. В перспективе определение микровезикул поможет выявить пациентов с высоким риском развития инсульта. Дальнейшие работы должны определить диагностическую и прогностическую значимость различных фенотипов микровезикул в отношении исходов инсульта. Актуально также изучение микровезикул в качестве мишеней для лечения и профилактики инсульта.

Peripheral blood microvesicles in patients with ischemic stroke are being profoundly investigated. Most works indicate an increase in the level of circulating microvesicles during different periods of stroke. The available data suggest that the level of microvesicles is a potential biomarker of the atherothrombotic subtype of ischemic stroke. Stroke severity, brain lesion volume, and outcome correlate with the level of microvesicles in peripheral blood. In the long term, the detection of microvesicles will help identify patients at high risk of stroke. Further work should determine the diagnostic and prognostic role of different microvesicle phenotypes in relation to stroke outcomes. Microvesicles should be also evaluated as targets for the treatment and prevention of stroke.

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The authors declare that there are no conflicts of interest present.