arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2015-21-4-334-348arthyper-297Research ArticleЛЕКЦИЯLECTUREРоль сахароснижающих препаратов в контроле артериального давления у пациентов с сахарным диабетом 2 типаThe role of glucose-lowering drugs in blood pressure control in patients with type 2 diabetes mellitusБабенкоА. Ю.BabenkoA. Yu.

доктор медицинских наук, заведующая научно-исследовательской лабораторией диабетологии Института эндокринологии, пр. Пархоменко, д. 15, Санкт-Петербург, 194156;

доцент кафедры терапии факультетской с курсом эндокринологии имени Г.Ф. Ланга, Санкт-Петербург

MD, PhD, Head, Research Laboratory of Diabetology, 15 Parkhomenko avenue, St Petersburg, 194156;

Associate Professor, Department of Therapy № 1 with the Course of Endocrinology, Cardiology and Functional Diagnostics n. a.G. F. Lang, St Petersburg

alina_babenko@mail.ruФедеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской Федерации; Государственное бюджетное образовательное учреждение высшего профессионального образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияV.A. Almazov Federal North-West Medical Research Centrуж First Pavlov State Medical University of St. PetersburgRussian Federation201504122015214334348Copyright © Бабенко А.Ю., 20152015Бабенко А.Ю.Babenko A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/297

Высокий вклад в развитие сосудистых осложнений сахарного диабета 2‑го типа (СД2) не только гипергликемии, но и таких компонентов синдрома инсулинорезистентности, как ожирение, дислипидемия и артериальная гипертензия (АГ), диктует необходимость учитывать влияние на них различных факторов. Начало XXI века характеризуется появлением целого ряда новых фармакологических агентов для лечения СД2, а также изменением концепции подхода к лечению с глюкоцентрической на многофакторную. Создание новых групп противодиабетических препаратов (ПП) с множественными негликемическими эффектами существенно усложнило выбор терапии для каждого конкретного больного и, несомненно, требует расширения знаний специалистов в этой области. Настоящий обзор посвящен одному из негликемических эффектов — влиянию различных групп ПП на уровень артериального давления у пациентов с СД2. Мы надеемся, что представленная работа позволит врачам лучше ориентироваться в выборе ПП при СД2 и сопутствующей АГ и принимать оптимальные решения в каждом индивидуальном случае.

Various factors contribute the development of cardiovascular complications in type 2 diabetes mellitus (DM2): hyperglycemia and components of insulin resistance syndrome, including obesity, dyslipidemia and arterial hypertension. All of them should be considered in therapeutic strategies. In the beginning of 21st century new pharmacological agents were developed leading to the major changes in DM2 treatment. So, an ideal treatment should have not only a glucose-lowering effect, but other (“non-glycemic”) actions affecting multiple coexistent factors. Since the novel classes of antidiabetic drugs with additional favorable pleiotropic effects independent from direct glucose-lowering effect have been introduced, the choice of an appropriate agent has become more complicated and requiresindividual approach and wide knowledge in this area. The present articles reviews various groups of glucose-lowering agents and their effects on blood pressure level in DM2 patients. We believe it will help to make the right individual choice of an antidiabetic agent taking into account its pleiotropic effects.

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The authors declare that there are no conflicts of interest present.