arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2015-21-6-604-613arthyper-343Research ArticleСтатьиArticlesНекоторые особенности кардиоваскулярного и метаболического статуса у мужчин молодого возраста с предгипертензией в зависимости от значений ранней постнагрузочной гликемииSome features of cardiovascular and metabolic status in young males with prehypertension depending on the level of early post-load glycemiaБарсуковА. В.BarsukovA. V.

доктор медицинских наук, профессор, заместитель начальника кафедры госпитальной терапии ФГБВОУ ВО «ВМА им. С. М. Кирова» Минобороны России

ул. Академика Лебедева, д. 6, Санкт-Петербург, Россия, 194044

MD, PhD, DSc, Professor, Deputy Chief, Department of Internal Diseases, Military Medical Academy named after S. M. Kirov

6 Academician Lebedev street, St Petersburg, 194044 Russia

avbarsukov@yandex.ruМирохинаМ. А.MirokhinaM. A.

врач-терапевт клиники госпитальной терапии ФГБВОУ ВО «ВМА им. С. М. Кирова» Минобороны России

MD, Physician, Department of Internal Diseases, Military Medical Academy named after S. M. Kirov

СердюковД. Ю.SerdyukovD. Y.

кандидат медицинских наук, докторант кафедры госпитальной терапии ФГБВОУ ВО «ВМА им. С. М. Кирова» Минобороны России

MD, PhD, Doctoral Candidate, Department of Internal Diseases, Military Medical Academy named after S. M. Kirov

Федеральное государственное бюджетное военное образовательное учреждение высшего образования «Военно-медицинская академия имени С. М. Кирова» Министерства обороны Российской Федерации, Санкт-Петербург, РоссияРоссияMilitary Medical Academy named after S. M. Kirov, St Petersburg, RussiaRussian Federation201502022016216604613Copyright © Барсуков А.В., Мирохина М.А., Сердюков Д.Ю., 20162016Барсуков А.В., Мирохина М.А., Сердюков Д.Ю.Barsukov A.V., Mirokhina M.A., Serdyukov D.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/343

Цель исследования — осуществить оценку скрининговых показателей состояния сердечно- сосудистой системы, основных видов обмена веществ, имеющих прогностическую ценность, у мужчин молодого возраста с предгипертензией в зависимости от значений гликемии в одночасовой точке стандартного орального глюкозотолерантного теста (ОГТТ).

Материалы и методы

Материалы и методы. В исследование были включены 105 пациентов с предгипертензией, имевших тощаковую эугликемию, нормальную толерантность к глюкозе и не страдавших кардиоваскулярными и другими клинически значимыми заболеваниями. На основании результатов ОГТТ участники исследования были разделены на две группы в зависимости от гликемии плазмы в одночасовой точке теста. В 1‑ю группу вошли 58 пациентов с уровнем глюкозы в одночасовой точке ОГТТ < 8,6 ммоль/л (средний возраст 38 ± 5 лет). Во 2‑ю группу вошли 47 пациентов с гликемией через 1 час ОГТТ ≥ 8,6 ммоль/л (средний возраст 39 ± 5 лет). Группы были сопоставимы по полу, возрасту, индексу массы тела, офисному уровню артериального давления. Оценены гемодинамические, электрокардиографические, эхокардиографические, лабораторные биохимические показатели. Полученные данные были обработаны с помощью программы «Statistica for Windows» (версия 10.0). Оценку групповых различий проводили определением значения t‑критерия Стьюдента и зависимости между категориальными переменными по Пирсону (критерий χ 2).

Результаты

Результаты. Из всего спектра полученных данных у испытуемых 1 и 2 групп были установлены значимые различия по содержанию мочевой кислоты в сыворотке крови (р = 0,005) и отношению аполипопротеин В / аполипопротеин А1 (апоВ/апоА1, р = 0,04).

Выводы

Выводы. Нормотолерантным мужчинам молодого возраста с предгипертензией и ранней постнагрузочной гипергликемией свойственны неблагоприятные изменения со стороны пуринового и липидного видов обмена веществ при отсутствии структурно-функциональных отклонений со стороны сердечно-сосудистой системы.

Objective

Objective. To assess the screening prognostic indicators of cardiovascular system, basic types of metabolism in young males with prehypertension, depending on the values of glucose 1‑hour after glucose load in standard oral glucose tolerance test (OGTT).

Design and methods

Design and methods. The study included 105 patients with prehypertension who had fasting euglycemia, normal glucose tolerance and did not suffer from cardiovascular or other clinically relevant internal diseases. Based on the results of OGTT study participants were divided into two groups according to plasma glucose level 1‑hour after glucose load. The 1st group included 58 patients with one hour post-load glucose level < 8,6 mmol/L (mean age 38 ± 5 years). The 2nd group included 47 patients with one hour post-load glucose level ≥ 8,6 mmol/L (mean age 39 ± 5 years). The groups were matched by gender, age, body mass index, office blood pressure. Hemodynamic, electrocardiographic, echocardiographic and laboratory biochemical parameters were evaluated. The obtained data were processed using Statistica for Windows (version 10.0). Student t‑test and Pearson correlation were applied (criterion χ 2).

Results

Results. We found significant differences in serum uric acid levels (p = 0,005) and the ratio apolipoprotein B / apolipoprotein A1 (apoB/apoA1, p = 0,04) between groups 1 and 2.

Conclusions

Conclusions. Young males with early post-load hyperglycemia and prehypertension are characterized by unfavorable lipid and purine metabolism changes in the absence of structural-functional cardiovascular alterations.

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The authors declare that there are no conflicts of interest present.