arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2016-22-6-536-550arthyper-503Research ArticleОБЗОРREVIEWПоражение почек при артериальной гипертензии: можем ли мы доверять старым маркерам?Kidney injury in arterial hypertension: can we trust the old markers?МироноваС. А.MironovaS. A.

аспирант очной формы обучения научно-исследовательской лаборатории (НИЛ) патогенеза и терапии артериальной гипертензии научно-исследовательского отдела артериальной гипертензии (НИО АГ),

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

MD, PhD, Student, Department for Arterial Hypertension,

2 Akkuratov street, St Petersburg, 197341

panarinasa@gmail.comЗвартауН. Э.ZvartauN. E.

кандидат медицинских наук, старший научный сотрудник НИЛ патогенеза и терапии артериальной гипертензии НИО АГ;

старший научный сотрудник,

Санкт-Петербург

MD, PhD, Senior Researcher, Department for Arterial Hypertension;

Senior Researcher, 

St Petersburg

КонрадиА. О.KonradiA. O.

доктор медицинских наук, профессор, руководитель НИО АГ, заместитель генерального директора по научной работе;

директор Института трансляционной медицины, руководитель международной лаборатории «Системы поддержки принятия решений в медицине»,

Санкт-Петербург

Deputy General Director on Research;

Director of the Institute of Translational Medicine, Head, International Laboratory «Decision support system in medicine», 

St Petersburg

Федеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияV. A. Almazov Federal North-West Medical Research CentreRussian FederationФедеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Университет ИТМОРоссияV. A. Almazov Federal North-West Medical Research Centre; ITMO UniversityRussian Federation201610012017226536550Copyright © Миронова С.А., Звартау Н.Э., Конради А.О., 20172017Миронова С.А., Звартау Н.Э., Конради А.О.Mironova S.A., Zvartau N.E., Konradi A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/503

В связи с высокой распространенностью хронической болезни почек (ХБП) в настоящее время, а также рядом недостатков традиционных параметров оценки почечной функции в последние несколько лет все больше внимания уделяется поиску новых маркеров поражения почек для более ранней и точной диагностики начала ХБП. В представленном обзоре приведены данные литературы о традиционных маркерах поражения почек в сравнении с новыми биохимическими маркерами, отражающими в основном тубулоинтерстициальное повреждение почек, происходящее на более ранних этапах поражения почек, проанализирована возможность использования ряда биомаркеров, таких как липокалин, ассоциированный с желатиназой нейтрофилов, молекула почечного повреждения, цистатин С и печеночная форма белка, связывающая жирные кислоты, в ранней диагностике как острого, так и хронического поражения почек, в том числе при гипертензивной нефропатии.

Given the high prevalence of chronic kidney disease (CKD) at the present time, as well as a number of shortcomings of traditional parameters of kidney function estimation, in the last few years more and more attention is paid to the search for new renal injury markers for earlier and accurate diagnosis of the onset of CKD. This paper reviews the available evidence on traditional markers of renal injury in comparison with the new biochemical markers, reflecting mainly tubulointerstitial kidney injury that occurs in the earlier stages of kidney disease. Moreover, we discuss the potential of a number of biomarkers, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule‑1, cystatin C, and liver fatty acid binding protein for early diagnosis of both acute and chronic kidney disease, including hypertensive nephropathy.

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The authors declare that there are no conflicts of interest present.