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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2013-19-6-525-531</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-52</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>РОЛЬ СИНДРОМА ОБСТРУКТИВНОГО АПНОЭ ВО СНЕ ПРИ МАСКИРОВАННОЙ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ</article-title><trans-title-group xml:lang="en"><trans-title>THE ROLE OF OBSTRUCTIVE SLEEP APNEA SYNDROME IN MASKED HYPERTENSION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор кафедры внутренних болезней факультета последипломного образования, научный руководитель ГБУЗ «Тверской областной клинический кардиологический диспансер»;</p><p> Контактная информация: ГБУЗ «Тверской областной клинический кардиологический диспансер», Комсомольский пр., д. 19, Тверь, Россия, 170041. Тел.: +7 (4822) 52–05–05. Факс: +7 (4822) 52–84–21. Е-mail: ivanovcardio2010@yandex.ru (Иванов Александр Петрович).</p></bio><bio xml:lang="en"><p>Corresponding author: Tver Regional Cardiology Clinic, 19 Komsomolskiy av., Tver, Russia, 170041. Phone: +7 (4822) 52–05–05. Fax: +7 (4822) 52–84–21. Е-mail: ivanovcardio2010@yandex.ru (Alexander P. Ivanov, MD, PhD, Professor at the Department for Internal Diseases of the Faculty of Advanced Training at Tver State Medical Academy, the Head of Tver Regional Cardiology Clinic).</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мальцев</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Maltsev</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Врач кардиолог</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эльгардт</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Elgardt</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, заслуженный врач Российской Федерации, главный врач</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сдобнякова</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sdobnyakova</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заместитель главного врача по лечебной работе</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тверская государственная медицинская академия, Тверь.&#13;
Тверской областной клинический кардиологический диспансер, Тверь</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tver State Medical Academy, Tver.&#13;
Tver Regional Cardiology Clinic, Tver</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тверской областной клинический кардиологический диспансер, Тверь</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tver Regional Cardiology Clinic, Tver</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2013</year></pub-date><volume>19</volume><issue>6</issue><fpage>525</fpage><lpage>531</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иванов А.П., Мальцев К.А., Эльгардт И.А., Сдобнякова Н.С., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Иванов А.П., Мальцев К.А., Эльгардт И.А., Сдобнякова Н.С.</copyright-holder><copyright-holder xml:lang="en">Ivanov A.P., Maltsev K.A., Elgardt I.A., Sdobnyakova N.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/52">https://htn.almazovcentre.ru/jour/article/view/52</self-uri><abstract><p>Цель исследования — оценка показателей офисного и амбулаторного артериального давления (АД) у пациентов со стабильной и маскированной артериальной гипертензией (АГ) при наличии у них синдрома обструктивного апноэ во сне (СОАС).</p><sec><title> Материалы и методы</title><p> Материалы и методы. Изучено состояние 121 больного, имевшего в анамнезе указания на повышение АД с подтвержденным СОАС методом многофункционального мониторирования электрокардиограммы, АД и дыхания с помощью аппаратно-программного комплекса «Кардиотехника 04-АД3 (М)». Для сравнения уровней офисного и амбулаторного АД сформированы 2 группы пациентов — со стабильной и маскированной АГ.</p></sec><sec><title> Результаты</title><p> Результаты. Выявлены возрастные отличия, проявляющиеся в уровнях офисного и амбулаторного АД у лиц моложе 40 лет, а также по преобладанию мужчин при СОАС с маскированной АГ и более частым наличием у них курения. Отмечено увеличение в этой группе суточных показателей АД как в дневные, так и в ночные часы. При множественном регрессионном анализе выявлены наиболее значимые факторы маскированной АГ при СОАС — мужской пол, высоконормальное АД, курение и повышение АД в ночные часы.</p></sec><sec><title>Выводы</title><p>Выводы. У больных с повышением АД в анамнезе и нарушениями дыхания во время сна необходимо проведение многофункционального мониторирования АД и дыхания с целью своевременного выявления скрытого течения АГ, что существенно влияет на клинико-функциональные характеристики пациентов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To assess office and outpatient blood pressure (BP) in patients with the persistent and masked hypertension (HTN) and obstructive sleep apnea syndrome (OSAS).</p></sec><sec><title>Design and methods</title><p>Design and methods. We enrolled 121 subjects with BP increase and verified OSAS by multifunctional monitoring including registration of electrocardiogram, BP and respiration (Кardiotekhnika 04-BP3 (M), St Petersburg, Russia) that were divided into 2 groups: patients with stable and masked HTN.</p></sec><sec><title>Results</title><p>Results. The groups differed by age, office and ambulatory BP in subjects younger 40 years. Males were prevalent among patients with OSAS and masked HTN. Smoking rate was also higher in this group. Both daytime and nocturnal BP were higher in subjects with OSAS and masked HTN. According to multiple regression analysis there were several predictors of masked HTN in OSAS patients: male gender, high normal BP, smoking and BP elevation at night.</p></sec><sec><title>Conclusions</title><p>Conclusions. Multifunctional monitoring with the registration of BP and respiration is obligatory in patients with HTN and suspected sleep breathing disorders in order to diagnose latent HTN.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>маскированная артериальная гипертензия</kwd><kwd>стабильная артериальная гипертензия</kwd><kwd>синдром обструктивного апноэ во сне</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>masked hypertension</kwd><kwd>stable hypertension</kwd><kwd>obstructive sleep apnea syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lattimore J.D., Celermajer D.S., Wilcox I. Obstructive sleep apnea and cardiovascular disease // J. Am. Coll. Cardiol. — 2003. — Vol. 41, № 9. — P. 429–437.</mixed-citation><mixed-citation xml:lang="en">Lattimore J.D., Celermajer D.S., Wilcox I. 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