arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2017-23-2-88-102arthyper-583Research ArticleСтатьиArticlesФУНКЦИОНАЛЬНАЯ ГЕТЕРОГЕННОСТЬ ЭНДОТЕЛИЯ (ОБЗОР)FUNCTIONAL HETEROGENEITY OF THE ENDOTHELIUM (THE REVIEW)ВасинаЛ. В.VasinaL. V.

доктор медицинских наук, старший научный сотрудник научно-исследовательской лаборатории микроциркуляции Института экспериментальной медицины

MD, PhD, DSc, Senior Scientist, Laboratory of Microcirculation, Institute of Experimental Medicine

lubov.vasina@gmail.comВласовТ. Д.VlasovT. D.

доктор медицинских наук, профессор, ведущий научный сотрудник научно- исследовательской лаборатории микроциркуляции Института экспериментальной медицины ФГБУ «СЗФМИЦ им. В.А. Алмазова» Минздрава России, заведующий кафедрой патофизиологии с курсом клинической патофизиологии ГБОУ ВПО ПСПбГМУ им. И.П. Павлова Минздрава России

MD, PhD, DSc, Рrofessor, Leading Researcher, Laboratory of Microcirculation, Institute of Experimental Medicine, V.A. Almazov Federal North-West Medical Research Centre, Head, Department of Pathophysiology, the First Pavlov State Medical University of St. Petersburg

lubov.vasina@gmail.comПетрищевН. Н.PetrishchevN. N.

доктор медицинских наук, руководитель НИЛ микроциркуляции Института экспериментальной медицины ФГБУ «СЗФМИЦ им. В.А. Алмазова» Минздрава России, профессор кафедры патофизиологии с курсом клинической патофизиологии ГБОУ ВПО ПСПбГМУ им. И.П. Павлова Минздрава России

MD, PhD, DSc, Professor, Head, Laboratory of Microcirculation, Institute of Experimental Medicine, V.A. Almazov Federal North-West Medical Research Centre, Рrofessor, Department of Pathophysiology, the First Pavlov State Medical University of St. Petersburg

lubov.vasina@gmail.comФедеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр имени B. A. Алмaзoвa» Министерства здравоохранения Российской ФедерацииРоссияV. A.Almazov Federal North-West Medical Research CentreRussian FederationФедеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр имени B. A. Алмaзoвa» Министерства здравоохранения Российской Федерации Федеральное государственное образовательное учреждение высшего профессионального образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияV. A.Almazov Federal North-West Medical Research Centre Pavlov First St. Petersburg State Medical UniversityRussian Federation20171505201723288102Copyright © Васина Л.В., Власов Т.Д., Петрищев Н.Н., 20172017Васина Л.В., Власов Т.Д., Петрищев Н.Н.Vasina L.V., Vlasov T.D., Petrishchev N.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/583

На основании данных отечественной и зарубежной литературы в обзоре систематизированы сведения об особенностях строения и функциях эндотелия сосудов головного мозга, сердца, легких, печени и почек. Эндотелиальные клетки обладают важными функциями, реализация которых зависит от гемодинамики и клеточного микроокружения конкретного органа или ткани. Проявления дисфункции эндотелия, направленность и выраженность изменений образования отдельных эндотелиальных факторов обусловлены гетерогенностью эндотелия и зависят от структуры, биохимической организации и функции органа. Понимание различий в морфологии и функциях различных субпопуляций эндотелиальных клеток имеет большое значение для лечения эндотелиальных дисфункций, протезирования сосудов, для реваскуляризации и регенерации ишемизированных органов.

 

The paper summarizes data about the structure and function of the endothelium of the brain vessels, heart, lungs, liver and kidneys. Endothelial cells have important functions, the implementation of which depends on the hemodynamic and cellular microenvironment of a particular organ or tissue. The manifestations of endothelial dysfunction, changes in the direction and intensity of the formation of individual endothelial factors due to the heterogeneity of the endothelium, and depend on the structure, organization and biochemical functions of the authority. Understanding the differences in morphology, ultrastructure, gene expression and function of various subpopulations of endothelial cells may be of therapeutic relevance for regenerative medicine, cell therapy of endothelial dysfunctions and ischemic revascularization.

 

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The authors declare that there are no conflicts of interest present.