arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2017-23-5-383-394arthyper-681Research ArticleОБЗОРREVIEWRHO-КИНАЗА КАК КЛЮЧЕВОЙ УЧАСТНИК РЕГУЛЯЦИИ ТОНУСА СОСУДОВ В НОРМЕ И ПРИ СОСУДИСТЫХ РАССТРОЙСТВАХRHO-KINASE AS A KEY PARTICIPANT IN THE REGULATION OF VASCULAR TONE IN NORMAL CIRCULATION AND VASCULAR DISORDERSТарасоваО. С.TarasovaO. S.

Тарасова Ольга Сергеевна — доктор биологических наук, профессор кафедры физиологии человека и животных биологического факультета ФГБОУ ВО МГУ им. М. В. Ломоносова.

 

Olga S. Tarasova, PhD, Doctor of Biological Sciences, Professor, Department of Human and Animal Physiology, Faculty of Biology, Lomonosov Moscow State University.

Leninskie Gory 1, bld. 12, Moscow, 119234. 

ost.msu@gmail.comГайнуллинаД. К.GaynullinaD. K.

Гайнуллина Дина Камилевна — кандидат биологических наук, старший научный сотрудник кафедры физиологии человека и животных биологического факультета ФГБОУ ВО МГУ им. М. В. Ломоносова.

Москва.

Dina K. Gaynullina, Candidate of Biological Sciences, Senior Reseacher, Department of Human and Animal Physiology, Faculty of Biology, Lomonosov Moscow State University.

Moscow.

Федеральное государственное бюджетное  образовательное учреждение высшего образования  «Московский государственный университет  имени М. В. Ломоносова», Москва, Россия  Государственный научный центр Российской Федерации —  Институт медико-биологических проблем РАН.РоссияLomonosov Moscow State University, Moscow, Russia  Institute for Biomedical Problems, Russian Academy   of Sciences.Russian Federation201702112017235383394Copyright © Тарасова О.С., Гайнуллина Д.К., 20172017Тарасова О.С., Гайнуллина Д.К.Tarasova O.S., Gaynullina D.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/681

Rho-киназа участвует в регуляции функций практически всех клеток нашего организма. Ключевым активатором Rho-киназы является малый гуанозинтрифосфат (ГТФ)-связывающий белок RhoA, но существуют и RhoA-независимые механизмы регуляции этого фермента. В данном обзоре рассмотрены механизмы, влияющие на активность Rho-киназы в гладкой мышце и эндотелии сосудов, ее роль в регуляции фундаментальных физиологических процессов в этих клетках, а также участие в патогенезе сосудистых расстройств при таких заболеваниях, как системная и легочная артериальная гипертензия и сахарный диабет.

Rho-kinase was shown to regulate the functions of almost all cells of our body. The key activator of Rhokinase is the small guanosine triphosphate (GTP)-binding protein RhoA, but RhoA-independent mechanisms of Rho-kinase regulation exist as well. In this review we describe the mechanisms affecting Rho-kinase activity in vascular smooth muscle and endothelial cells, Rho-kinase regulatory influences on fundamental physiological processes in these cells, as well as its role in the pathogenesis of vascular disorders in systemic and pulmonary arterial hypertension and diabetes mellitus.

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The authors declare that there are no conflicts of interest present.