arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2017-23-5-421-432arthyper-685Research ArticleОБЗОРREVIEWГЕНДЕРНЫЕ РАЗЛИЧИЯ В ПРОЯВЛЕНИИ ЛЕГОЧНОЙ ГИПЕРТЕНЗИИ. ВЛИЯНИЕ ЖЕНСКОГО ПОЛОВОГО ГОРМОНА ЭСТРАДИОЛАGENDER DIFFERENCES IN THE DEVELOPMENT OF PULMONARY HYPERTENSION: EFFECTS OF FEMALE SEX HORMONE ESTRADIOLМедведеваН. А.MedvedevaN. A.

Медведева Наталия Александровна — доктор биологических наук, профессор, ведущий научный сотрудник кафедры физиологии человека и животных биологического ф-та ФГБУ ВПО МГУ им. М. В. Ломоносова.

 

Natalia A. Medvedeva, PhD in Biology Sciences, DSc, Professor, Leading Researcher, the Department of Human and Animal Physiology, Biological Faculty, Lomonosov Moscow State University.

namedved@gmail.comПаньковаН. В.PankovaN. V.

Панькова Надежда Владимировна — аспирант кафедры физиологии человека и животных биологического ф-та ФГБУ ВПО МГУ им. М. В. Ломоносова.

 

Nadezhda V. Pankova, Postgraduate Student, the Department of Human and Animal Physiology, Biological Faculty, Lomonosov Moscow State University.

Moscow.

АртемьеваМ. М.ArtemievaM. A.

Артемьева Марина Михайловна — кандидат биологических наук, научный сотрудник кафедры физиологии человека и животных биологического ф-та ФГБУ ВПО МГУ им. М. В. Ломоносова.

Москва.

Marina M. Artemieva — PhD in Biology Sciences, Researcher, the Department of Human and Animal Physiology, Biological Faculty, Lomonosov Moscow State University.

Moscow.

Федеральное государственное бюджетное   образовательное учреждение высшего образования   «Московский государственный университет   имени М. В. Ломоносова».РоссияLomonosov Moscow State University.Russian Federation201702112017235421432Copyright © Медведева Н.А., Панькова Н.В., Артемьева М.М., 20172017Медведева Н.А., Панькова Н.В., Артемьева М.М.Medvedeva N.A., Pankova N.V., Artemieva M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/685

Легочная гипертензия (ЛГ) — группа гетерогенных заболеваний, отличающихся своей этиологией и фенотипом, но объединенных основными симптомами заболевания — повышением артериального давления в малом круге кровообращения и гипертрофией правого желудочка сердца. Важной особенностью всех типов ЛГ является гендерная зависимость в проявлении этого заболевания. Согласно клиническим данным женская часть населения в большей степени подвержена ЛГ, что противоречит представлениям о протективном действии женского полового гормона. Это явление получило название эстрадиолового парадокса. В обзоре обсуждаются возможные механизмы гендерных различий в проявлении ЛГ, сравниваются экспериментальные данные, полученные на животных, с результатами клинических исследований, анализируются геномный и негеномный эффект действия эстрадиола на состояние сердечнососудистой системы, возможное участие метаболитов эстрадиола и механизмы гипертрофии правого желудочка сердца.

Pulmonary hypertension (PH) encompasses a heterogeneous group of diseases that are characterized by elevated pulmonary artery pressures. Female gender is known to be one of the most powerful risk factors for the development of PH. However, only recent evidence has provided better understanding of the relationship between sex, gender, sex hormones, and PH. Estrogens have been found to be protective in cardiovascular system, but not in case of PH. This phenomenon was called “estrogen paradox”. This review focuses on pulmonary hypertension, sex hormone effects in PH, sex hormones synthesis, metabolism and receptor physiology, increased pulmonary vascular resistance, right ventricular failure.

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The authors declare that there are no conflicts of interest present.