arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2014-20-5-377-383arthyper-71Research ArticleОБЗОРREVIEWЭЭСПЕРИМЕНТАЛЬНЫЕ МОДЕЛИ МЕТАБОЛИЧЕСКОГО СИНДРОМАEXPERIMENTAL MODELS OF METABOLIC SYNDROMEКравчукЕ. Н.KravchukE. N.

Кандидат медицинских наук, старший научный сотрудник научно-исследовательской лаборатории диабетологии ФМИЦ им. В.А. Алмазова;

ФГБУ «Федеральный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России, ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341. Тел./факс: +7(812)702–55–95. 

 

Corresponding author: Federal Almazov Medical Research Centre, 2 Akkuratov st.,St Petersburg,Russia, 197341.  Tel./fax: +7(812)702–55–95. E-mail: kravchuke@gmail.com (Ekaterina N. Kravchuk, MD, PhD, Senior Researcher at the Laboratory of Diabetology in theInstituteofEndocrinologyat the Federal Almazov Medical Research Centre).

kravchuke@gmail.comГалагудзаМ. М.GalagudzaM. M.

Доктор медицинских наук, руководитель Института экспериментальной медицины ФМИЦ им. В.А. Алмазова

kravchuke@gmail.comФедеральный медицинский исследовательский центр им. В.А. Алмазова, Санкт-ПетербургРоссияFederal Almazov Medical Research Centre, St PetersburgRussian Federation201427022015205377383Copyright © Кравчук Е.Н., Галагудза М.М., 20152015Кравчук Е.Н., Галагудза М.М.Kravchuk E.N., Galagudza M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/71

Распространенность метаболического синдрома (МС) в современном обществе прогрессивно увеличивается в течение последних лет, что становится причиной повышенной заболеваемости и смертности. Использование экспериментальных моделей позволяет понять причины развития и прогрессирования МС, исследовать потенциальные методы его профилактики и лечения. МС представляет собой многофакторный комплекс патологических изменений, и выбор адекватной экспериментальной модели является основополагающим в изучении данного состояния. В этом обзоре обсуждаются наиболее распространенные генетические модели, используемые для изучения МС, а также методики моделирования данного синдрома путем внешних воздействий.

Metabolic syndrome (MS) is one of the most significant problems of modern society. Rapidly growing prevalence of MS results in high morbidity and mortality due to its vascular complications. Experimental studies can help us to understand the underlying mechanisms of MS development and progression, as well as to develop potential therapeutic interventions. MS represents a multifactorial complex of pathological changes and the selection of an appropriate experimental model is crucial in investigation of this condition. In this review, we will discuss the most common genetic animal models of MS, along with the models in which MS is caused by exogenous factors.

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The authors declare that there are no conflicts of interest present.