arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2017-23-6-561-573arthyper-718Research ArticleСЕКЦИЯ РКО ПО АВТОНОМНОЙ РЕГУЛЯЦИИSECTION OF RSC ON THE AUTONOMIC REGULATIONСВЯЗЬ МЕЖДУ ВРЕМЕНЕМ ГОДА И РАЗВИТИЕМ ВАЗОРЕНАЛЬНОЙ ГИПЕРТЕНЗИИTHE RELATIONSHIP BETWEEN THE SEASON OF THE YEAR AND THE VASORENAL HYPERTENSION OCCURRENCEКузьменкоН. В.KuzmenkoN. N.

Кузьменко Наталия Владимировна — кандидат биологических наук, старший научный сотрудник отдела экспериментальной физиологии и фармакологии; , старший научный сотрудник лаборатории биофизики кровообращения.

  

Nataliya V. Kuzmenko, PhD in Biology Sciences, Senior Researcher, Department for Experimental Physiology and Pharmacology;, Senior Researcher, Laboratory of Byophysics of Blood Circulation.

St. Petersburg.

kuzmenko@niiekf.ruПлиссМ. Г.PlissM. G.

Плисс Михаил Гениевич — кандидат медицинских наук, заведующий отделом экспериментальной физиологии и фармакологии;  заведующий лабораторией биофизики кровообращения.

Санкт-Петербург.

Mikhail G. Pliss, MD, PhD, Head, Department for Experimental Physiology and Pharmacology;  Head, Laboratory of Byophysics of Blood Circulation.

St. Petersburg.

ЦырлинВ. А.TsyrlinV. A.

Цырлин Виталий Александрович — доктор медицинских наук, главный научный сотрудник отдела экспериментальной физиологии и фармакологии ФГБУ «НМИЦ им. В. А. Алмазова» Минздрава России, профессор кафедры фармакологии;  профессор кафедры фармакологии Санкт-Петербургского государственного университета.

Санкт-Петербург.

Vitaliy A. Tsyrlin, MD, PhD, DSc, Professor, Leading Researcher, Department for Experimental Physiology and Pharmacology;  Professor, Department for Pharmacology, St Petersburg State University.

St. Petersburg.

 Федеральное государственное бюджетное учреждение  «Национальный медицинский исследовательский центр  имени В. А. Алмазова» Министерства здравоохранения  Российской Федерации;  Федеральное государственное бюджетное  образовательное учреждение высшего образования  «Первый Санкт-Петербургский государственный  медицинский университет имени академика И. П. Павлова»  Министерства здравоохранения Российской Федерации.РоссияAlmazov National Medical Research Centre; First Pavlov State Medical University of St. Petersburg.Russian Federation Федеральное государственное бюджетное учреждение  «Национальный медицинский исследовательский центр  имени В. А. Алмазова» Министерства здравоохранения  Российской Федерации; Санкт-Петербургский государственный университет.РоссияAlmazov National Medical Research Centre; St Petersburg State University.Russian Federation201711012018236561573Copyright © Кузьменко Н.В., Плисс М.Г., Цырлин В.А., 20182018Кузьменко Н.В., Плисс М.Г., Цырлин В.А.Kuzmenko N.N., Pliss M.G., Tsyrlin V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/718

Objective. The aim of this work was to study the impact of seasons on the incidence of the experimental arterial hypertension. Design and methods. We applied the model of vasorenal hypertension “2 kidney, 1 clip” in Wistar male rats in standard laboratory conditions. We compared the following parameters in the groups with clipped arteries in autumn, winter and spring: systolic blood pressure, beat-to-beat interval, low- and high-frequency components of heart rate variability. Results. The risk of vasorenal hypertension occurrence was higher in spring (56 %). More seldom vasorenal hypertension developed in winter (20 % of animals), and an increase in density of low and high-frequency components of heart rate variability was observed after applying renal artery clamp in the winter group. There was a clear correlation between an increase in the average monthly variability of atmospheric pressure and a decrease in the frequency of vasorenal hypertension occurrence. Conclusions. We conclude that the season has an impact on the development of hypertension, which probably is due to the seasonal changes in sympathetic and parasympathetic activity. We assume that clear seasonal dynamics of atmospheric pressure variability causes the seasonal variations in the functioning of the cardiovascular and autonomic nervous systems in standard laboratory conditions.

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The authors declare that there are no conflicts of interest present.