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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2014-20-5-406-414</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-74</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURE</subject></subj-group></article-categories><title-group><article-title>МОЛОДОЙ И ПОЖИЛОЙ ПАЦИЕНТ С АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ: ОСОБЕННОСТИ ЛЕЧЕНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>HYPERTENSION TREATMENT IN THE YOUNG AGE AND IN THE ELDERLY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конради</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Konradi</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Доктор медицинских наук, профессор, руководитель научно-исследовательского отдела артериальной гипертензии, заместитель директора по научной работе ФМИЦ им.В.А. Алмазова.</p><p> Контактная информация: ФГБУ «Федеральный медицинский исследовательский центр имени В.А. Алмазова» Минздрава России, научно-исследовательский отдел артериальной гипертензии, ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341.   Тел.: +7(812)702–68–10. E-mail: konradi@almazovcentre.ru (Конради Александра Олеговна).</p></bio><bio xml:lang="en"><p>Federal Almazov Medical Research Centre, 2 Akkuratov street, St Petersburg, Russia, 197341.  Tel.: +7(812)702–68–10. MD, PhD, Professor, Vice-Director on Research of the Federal Almazov Medical Research Centre, Head of the Hypertension Research Department at the Federal Almazov Medical Research Centre</p></bio><email xlink:type="simple">konradi@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральный медицинский  исследовательский центр имени В.А. Алмазова, Санкт-Петербург<country>Россия</country></aff><aff xml:lang="en">Federal Almazov Medical Research Centre, St Petersburg<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>27</day><month>02</month><year>2015</year></pub-date><volume>20</volume><issue>5</issue><fpage>406</fpage><lpage>414</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Конради А.О., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Конради А.О.</copyright-holder><copyright-holder xml:lang="en">Konradi A.O.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/74">https://htn.almazovcentre.ru/jour/article/view/74</self-uri><abstract><p>В обзоре приводятся данные современных рекомендаций по лечению артериальной гипертензии у пациентов различного возраста, а также патогенетические основы повышения артериального давления в зависимости от возраста. Помимо этого обсуждаются специфические проблемы целевых уровней артериального давления, профилактика когнитивных нарушений у пожилых, особенности побочных эффектов лекарств в различном возрасте.</p></abstract><trans-abstract xml:lang="en"><p>The review assesses the current guidelines of hypertension treatment in different age groups and pathophysiology of hypertension according to age. Specific questions concerning prevention of cognitive decline in the elderly are also discussed as well as target blood pressure levels and side effects of the drugs.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>возраст</kwd><kwd>когнитивная дисфункция</kwd><kwd>пожилые</kwd><kwd>кандесартан</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>elderly</kwd><kwd>cognitive dysfunction</kwd><kwd>candesartan</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">2013 Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the EuropeanSociety of Cardiology (ESC) // J. Hypertens. — 2013. — Vol. 31, № 7. — P. 1281–1357.</mixed-citation><mixed-citation xml:lang="en">2013 Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the EuropeanSociety of Cardiology (ESC) // J. Hypertens. — 2013. — Vol. 31, № 7. — P. 1281–1357.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ong K.L., Cheung B.M.Y., Man Y.B. et al. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999–2004 // Hypertension. — 2007. — Vol. 31, № 49. — P. 69–75.</mixed-citation><mixed-citation xml:lang="en">Ong K.L., Cheung B.M.Y., Man Y.B. et al. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999–2004 // Hypertension. — 2007. — Vol. 31, № 49. — P. 69–75.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Franklin S.S., Jacobs M.J., Wong N.D., L’Italien G.J., Lapuerta P. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III // Hypertension. — 2001. — Vol. 37, № 3. — P. 869–874.</mixed-citation><mixed-citation xml:lang="en">Franklin S.S., Jacobs M.J., Wong N.D., L’Italien G.J., Lapuerta P. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III // Hypertension. — 2001. — Vol. 37, № 3. — P. 869–874.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Lloyd-Jones D.M., Evans J.C., Larson M.G. et al. Differential control of systolic and diastolic blood pressure: factors associated with lack of blood pressure control in the community // Hypertension. — 2000. — Vol. 36, № 4. — P. 594–599.</mixed-citation><mixed-citation xml:lang="en">Lloyd-Jones D.M., Evans J.C., Larson M.G. et al. Differential control of systolic and diastolic blood pressure: factors associated with lack of blood pressure control in the community // Hypertension. — 2000. — Vol. 36, № 4. — P. 594–599.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kannel W.B., Dannenberg A.L., Abbott R.D. Unrecognized myocardial infarction and hypertension: the Framingham Study // Am. Heart J. — 1985. — Vol. 109, № 3, Pt. 1. — P. 581–585.</mixed-citation><mixed-citation xml:lang="en">Kannel W.B., Dannenberg A.L., Abbott R.D. Unrecognized myocardial infarction and hypertension: the Framingham Study // Am. Heart J. — 1985. — Vol. 109, № 3, Pt. 1. — P. 581–585.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Pannier B., Brunel P., Aroussey W.E., Lacolley P., Safar M.E. Pulse pressure and echocardiographic findings in essential hypertension // J. Hypertens. — 1989. — Vol. 7, № 2. — P. 127–132.</mixed-citation><mixed-citation xml:lang="en">Pannier B., Brunel P., Aroussey W.E., Lacolley P., Safar M.E. Pulse pressure and echocardiographic findings in essential hypertension // J. Hypertens. — 1989. — Vol. 7, № 2. — P. 127–132.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Gardin J.M., Gottdiener J.S., Wong N.D. et al. Left ventricular mass in the elderly. The Cardiovascular Health Study // Hypertension. — 1997. — Vol. 29, № 5. — P. 1095–1103.</mixed-citation><mixed-citation xml:lang="en">Gardin J.M., Gottdiener J.S., Wong N.D. et al. Left ventricular mass in the elderly. The Cardiovascular Health Study // Hypertension. — 1997. — Vol. 29, № 5. — P. 1095–1103.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rutan G.H., McDonald R.H., Kuller L.H. A historical perspective of systolic vs diastolic blood pressure from an epidemiological and clinical trial viewpoint // J. Clin. Epidemiol. — 1989. — Vol. 42, № 7. — P. 663–673.</mixed-citation><mixed-citation xml:lang="en">Rutan G.H., McDonald R.H., Kuller L.H. A historical perspective of systolic vs diastolic blood pressure from an epidemiological and clinical trial viewpoint // J. Clin. Epidemiol. — 1989. — Vol. 42, № 7. — P. 663–673.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kannel W.B., Wilson P.W.F., Silbershatz H. et al. Epidemiology of risk factor clustering in elevated blood pressure // Gotto A.M., Lenfant C., Paoletti R. (eds). Multiple Risk Factors in Cardiovascular Disease. — The Netherlands: Klewer Academic Publishers and Fondazione Giovanni Lorenzini, 1998. — P. 325–333.</mixed-citation><mixed-citation xml:lang="en">Kannel W.B., Wilson P.W.F., Silbershatz H. et al. Epidemiology of risk factor clustering in elevated blood pressure // Gotto A.M., Lenfant C., Paoletti R. (eds). Multiple Risk Factors in Cardiovascular Disease. — The Netherlands: Klewer Academic Publishers and Fondazione Giovanni Lorenzini, 1998. — P. 325–333.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Reaven G.M. Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in the etiology clinical course of hypertension // Am. J. Med. — 1991. — Vol. 90, № 2А. — P. 7S–12S.</mixed-citation><mixed-citation xml:lang="en">Reaven G.M. Insulin resistance, hyperinsulinemia, and hypertriglyceridemia in the etiology clinical course of hypertension // Am. J. Med. — 1991. — Vol. 90, № 2А. — P. 7S–12S.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Van Bortel L.M., Struijker-Boudier H.A., Safar M.E. Pulse pressure, arterial stiffness, and drug treatment of hypertension // Hypertension. — 2001. — Vol. 38, № 4. — P. 914.</mixed-citation><mixed-citation xml:lang="en">Van Bortel L.M., Struijker-Boudier H.A., Safar M.E. Pulse pressure, arterial stiffness, and drug treatment of hypertension // Hypertension. — 2001. — Vol. 38, № 4. — P. 914.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Franklin S. Hypertension in older people: part 1 // J. Clin. Hypertens. — 2006. — Vol. 8, № 6. — P. 444–449.</mixed-citation><mixed-citation xml:lang="en">Franklin S. Hypertension in older people: part 1 // J. Clin. Hypertens. — 2006. — Vol. 8, № 6. — P. 444–449.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Izzo J. Stagnation and the critical need for hypertension subtyping // Clin. Hypertens. — 2008. — March. — Vol. 10, № 3. — P. 174–175.</mixed-citation><mixed-citation xml:lang="en">Izzo J. Stagnation and the critical need for hypertension subtyping // Clin. Hypertens. — 2008. — March. — Vol. 10, № 3. — P. 174–175.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G., Grassi G. Treating very elderly hypertensive patients is rewarding: the HYVET results // Curr. Hypertens. Rep. — 2008. — Vol. 10, № 4. — P. 301–302.</mixed-citation><mixed-citation xml:lang="en">Mancia G., Grassi G. Treating very elderly hypertensive patients is rewarding: the HYVET results // Curr. Hypertens. Rep. — 2008. — Vol. 10, № 4. — P. 301–302.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Mahvan T.D.1, Mlodinow S.G. JNC 8: What's covered, what's not, and what else to consider // J. Fam. Pract. — 2014. — Vol. 63, № 10. — P. 574–584.</mixed-citation><mixed-citation xml:lang="en">Mahvan T.D.1, Mlodinow S.G. JNC 8: What's covered, what's not, and what else to consider // J. Fam. Pract. — 2014. — Vol. 63, № 10. — P. 574–584.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP) // J. Am. Med. Assoc. — 1991. — Vol. 265, № 24. — P. 3255–3264.</mixed-citation><mixed-citation xml:lang="en">SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP) // J. Am. Med. Assoc. — 1991. — Vol. 265, № 24. — P. 3255–3264.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Williams B.R., Kim J. Cardiovascular drug therapy in the elderly: theoretical and practical considerations // Drugs Aging. — 2003. — Vol. 20, № 6. — P. 445–463.</mixed-citation><mixed-citation xml:lang="en">Williams B.R., Kim J. Cardiovascular drug therapy in the elderly: theoretical and practical considerations // Drugs Aging. — 2003. — Vol. 20, № 6. — P. 445–463.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs. diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) // J. Am. Med. Assoc. — 2002. — Vol. 288, № 23. — P. 2981–2997.</mixed-citation><mixed-citation xml:lang="en">ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs. diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) // J. Am. Med. Assoc. — 2002. — Vol. 288, № 23. — P. 2981–2997.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Messerli F.H., Grossman E., Goldbourt U. Are beta-block-ers efficacious as first-line therapy for hypertension in the elderly? A systematic review // J. Am. Med. Assoc. — 1998. — Vol. 279, № 23. — P. 1903–1907.</mixed-citation><mixed-citation xml:lang="en">Messerli F.H., Grossman E., Goldbourt U. Are beta-block-ers efficacious as first-line therapy for hypertension in the elderly? A systematic review // J. Am. Med. Assoc. — 1998. — Vol. 279, № 23. — P. 1903–1907.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Tu K., Campbell N.R.C, Chen Z., McAlister F.A. Use of beta-blockers for uncomplicated hypertension in the elderly: a cause for concern // J. Hum. Hypertens. — 2007. — Vol. 21, № 4. — P. 271–275.</mixed-citation><mixed-citation xml:lang="en">Tu K., Campbell N.R.C, Chen Z., McAlister F.A. Use of beta-blockers for uncomplicated hypertension in the elderly: a cause for concern // J. Hum. Hypertens. — 2007. — Vol. 21, № 4. — P. 271–275.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Rodgers J.E., Patterson J.H. Angiotensin II-receptor blockers: clinical relevance and therapeutic role // Am. J. Health Syst. Pharm. — 2001. — Vol. 58, № 8. — P. 671–683.</mixed-citation><mixed-citation xml:lang="en">Rodgers J.E., Patterson J.H. Angiotensin II-receptor blockers: clinical relevance and therapeutic role // Am. J. Health Syst. Pharm. — 2001. — Vol. 58, № 8. — P. 671–683.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Schrander J., Luders S., Kulschewski A. et al. Morbidity and mortality after stroke, eprosartan compared with nitrendipine for secondary prevention (MOSES study) // Stroke. — 2005. — Vol. 36, № 6. — P. 1218–1226.</mixed-citation><mixed-citation xml:lang="en">Schrander J., Luders S., Kulschewski A. et al. Morbidity and mortality after stroke, eprosartan compared with nitrendipine for secondary prevention (MOSES study) // Stroke. — 2005. — Vol. 36, № 6. — P. 1218–1226.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Petrella R.J.1, Shlyakhto E.V., Konradi A.O. et al. OSCAR Publication Group. Blood pressure responses to hypertension treatment and trends in cognitive function in patients with initially difficult-to-treat hypertension: a retrospective subgroup analysis of the Observational Study on Cognitive Function and SBP Reduction (OSCAR) study // J. Clin. Hypertens. (Greenwich). — 2012. — Vol. 14, № 2. — P. 78–84.</mixed-citation><mixed-citation xml:lang="en">Petrella R.J.1, Shlyakhto E.V., Konradi A.O. et al. OSCAR Publication Group. Blood pressure responses to hypertension treatment and trends in cognitive function in patients with initially difficult-to-treat hypertension: a retrospective subgroup analysis of the Observational Study on Cognitive Function and SBP Reduction (OSCAR) study // J. Clin. Hypertens. (Greenwich). — 2012. — Vol. 14, № 2. — P. 78–84.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Papademetriou V., Farsang C., Elmfeldt D. et al. Study on Cognition and Prognosis in the Elderly study group. Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension: the Study on Cognition and Prognosis in the Elderly (SCOPE) // J. Am. Coll. Cardiol. — 2004. — Vol. 44, № 6. — P. 1175–1180.</mixed-citation><mixed-citation xml:lang="en">Papademetriou V., Farsang C., Elmfeldt D. et al. Study on Cognition and Prognosis in the Elderly study group. Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension: the Study on Cognition and Prognosis in the Elderly (SCOPE) // J. Am. Coll. Cardiol. — 2004. — Vol. 44, № 6. — P. 1175–1180.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Akamine D., Filho M.K., Peres C.M. Drug-nutrient interactions in elderly people // Curr. Opin. Clin. Nutr. Metab. Care. — 2007. — Vol. 10, № 3. — P. 304–310.</mixed-citation><mixed-citation xml:lang="en">Akamine D., Filho M.K., Peres C.M. Drug-nutrient interactions in elderly people // Curr. Opin. Clin. Nutr. Metab. Care. — 2007. — Vol. 10, № 3. — P. 304–310.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Oliveria S.A., Lapuerta P., McCarthy B.D. et al. Physician-related barriers to the effective management of uncontrolled hypertension // Arch. Intern. Med. — 2002. — Vol. 162, № 4. — P. 413–420.</mixed-citation><mixed-citation xml:lang="en">Oliveria S.A., Lapuerta P., McCarthy B.D. et al. Physician-related barriers to the effective management of uncontrolled hypertension // Arch. Intern. Med. — 2002. — Vol. 162, № 4. — P. 413–420.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Hajjar I., Miller K., Hirth V. Age-related bias in the management of hypertension: a national survey of physicians’ opinions on hypertension in elderly adults // J. Gerontol. — 2002. — Vol. 57A, № 8. — P. M487–M491.</mixed-citation><mixed-citation xml:lang="en">Hajjar I., Miller K., Hirth V. Age-related bias in the management of hypertension: a national survey of physicians’ opinions on hypertension in elderly adults // J. Gerontol. — 2002. — Vol. 57A, № 8. — P. M487–M491.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Sica D.A. Rationale for fixed-dose combinations in the treatment of hypertension: the cycle repeats // Drugs. — 2002. — Vol. 62, № 3. — P. 443–462.</mixed-citation><mixed-citation xml:lang="en">Sica D.A. Rationale for fixed-dose combinations in the treatment of hypertension: the cycle repeats // Drugs. — 2002. — Vol. 62, № 3. — P. 443–462.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Franklin S.S. Systolic blood pressure: it's time to take control // Am. J. Hypertens. — 2004. — December. — Vol. 17, № 12, Pt. 2. — P. 49S–54S.</mixed-citation><mixed-citation xml:lang="en">Franklin S.S. Systolic blood pressure: it's time to take control // Am. J. Hypertens. — 2004. — December. — Vol. 17, № 12, Pt. 2. — P. 49S–54S.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ekpo E.B., Shah I.U., Fernando M.U., White A.D. Isolated systolic hypertension in the elderly: survey of practitioners’ attitude and management // Gerontology. — 1993. — Vol. 39, № 4. — P. 207–214.</mixed-citation><mixed-citation xml:lang="en">Ekpo E.B., Shah I.U., Fernando M.U., White A.D. Isolated systolic hypertension in the elderly: survey of practitioners’ attitude and management // Gerontology. — 1993. — Vol. 39, № 4. — P. 207–214.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
