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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2018-24-1-29-40</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-756</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>ГИПЕРТРОФИЧЕСКАЯ КАРДИОМИОПАТИЯ В СТАРШЕЙ ВОЗРАСТНОЙ ГРУППЕ: ВЛИЯНИЕ ФАКТОРОВ КАРДИОМЕТАБОЛИЧЕСКОГО РИСКА И ПОЛИМОРФИЗМА ГЕНА MADD</article-title><trans-title-group xml:lang="en"><trans-title>HYPERTROPHIC CARDIOMYOPATHY IN THE OLDER AGE GROUP: THE EFFECT OF CARDIOMETABOLIC RISK FACTORS AND RS2290149 AND RS10838692 OF THE MADD GENE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полякова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Poliakova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Полякова Анжелика Александровна — старший научный сотрудник научно-исследовательского отдела инфильтративных заболеваний сердца Института молекулярной биологии и генетики;  младший научный сотрудник лаборатории кардиомиопатий Института сердечно-сосудистых заболеваний. </p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"><p>St. Petersburg.</p></bio><email xlink:type="simple">lica.polyakova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гудкова</surname><given-names>А. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Gudkova</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гудкова Александра Яковлевна — доктор медицинских наук, профессор, ведущий научный сотрудник Института молекулярной биологии и генетики;  заведующая лабораторией кардиомиопатий Института сердечно-сосудистых заболеваний. </p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"><p>St. Petersburg.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крутиков</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Krutikov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крутиков Александр Николаевич — ведущий научный сотрудник научно-исследовательского отдела инфильтративных заболеваний сердца Института молекулярной биологии и генетики.</p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"><p>St. Petersburg.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семернин</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Semernin</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Семернин Евгений Николаевич — кандидат медицинских наук, руководитель научно-исследовательского отдела инфильтративных заболеваний сердца Института молекулярной биологии и генетики. </p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"><p>St. Petersburg.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козленок</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlenok</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Козленок Андрей Валерьевич — кандидат медицинских наук, заведующий научно-исследовательским отделом физиологии кровообращения.</p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"><p>St. Petersburg.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пыко</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pyko</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пыко Светлана Анатольевна — кандидат технических наук, старший научный сотрудник научно-исследовательского отдела инфильтративных заболеваний сердца Института молекулярной биологии и генетики. </p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"><p>St. Petersburg.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Костарева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kostareva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Костарева Анна Александровна — кандидат медицинских наук, директор Института молекулярной биологии и генетики. </p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"><p>St. Petersburg.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шляхто</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shlyakhto</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шляхто Евгений Владимирович — доктор медицинских наук, профессор, академик РАН, заслуженный деятель науки РФ, генеральный директор;   заведующий кафедрой терапии факультетской с курсом эндокринологии, кардиологии и функциональной диагностики имени Г. Ф. Ланга с клиникой; президент Российского кардиологического общества, главный кардиолог Санкт-Петербурга и Северо-Западного федерального округа.</p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"><p>St. Petersburg.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное бюджетное учреждение   «Национальный медицинский исследовательский центр  имени В. А. Алмазова» Министерства здравоохранения   Российской Федерации; Федеральное государственное бюджетное образовательное  учреждение высшего образования   «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова»   Министерства здравоохранения Российской Федерации.<country>Россия</country></aff><aff xml:lang="en">Almazov National Medical Research Centre; First Pavlov State Medical University of St. Petersburg.<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное государственное бюджетное учреждение   «Национальный медицинский исследовательский центр  имени В. А. Алмазова» Министерства здравоохранения   Российской Федерации.<country>Россия</country></aff><aff xml:lang="en">Almazov National Medical Research Centre.<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>12</day><month>03</month><year>2018</year></pub-date><volume>24</volume><issue>1</issue><fpage>29</fpage><lpage>40</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Полякова А.А., Гудкова А.Я., Крутиков А.Н., Семернин Е.Н., Козленок А.В., Пыко С.А., Костарева А.А., Шляхто Е.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Полякова А.А., Гудкова А.Я., Крутиков А.Н., Семернин Е.Н., Козленок А.В., Пыко С.А., Костарева А.А., Шляхто Е.В.</copyright-holder><copyright-holder xml:lang="en">Poliakova A.A., Gudkova A.Y., Krutikov A.N., Semernin E.N., Kozlenok A.V., Pyko S.A., Kostareva A.A., Shlyakhto E.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/756">https://htn.almazovcentre.ru/jour/article/view/756</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>гипертрофия левого желудочка различного генеза</kwd><kwd>идиопатическая гипертрофическая кардиомиопатия</kwd><kwd>гипертрофия левого желудочка</kwd><kwd>факторы кардиометаболического риска</kwd><kwd>полиморфные варианты гена MADD</kwd><kwd>коморбидная патология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>left ventricular hypertrophy of various origin</kwd><kwd>idiopathic hypertrophic cardiomyopathy</kwd><kwd>left ventricular hypertrophy</kwd><kwd>cardiometabolic risk factors</kwd><kwd>polymorphic variants of MADD gene</kwd><kwd>comorbidities</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Elliott PM, Anastasakis A, Borger MA, Borggrefe M, Cecchi F, Charron P et al. 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy. 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