arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2018-24-1-120-126arthyper-768Research ArticleЛЕКЦИЯLECTUREНОВЫЕ ВОЗМОЖНОСТИ УЛУЧШЕНИЯ КОНТРОЛЯ СИСТОЛИЧЕСКОГО АРТЕРИАЛЬНОГО ДАВЛЕНИЯ У ПАЦИЕНТОВ ПОЖИЛОГО ВОЗРАСТА: В ФОКУСЕ ФИКСИРОВАННАЯ КОМБИНАЦИЯ ИНДАПАМИДА-РЕТАРД И АМЛОДИПИНАNEW OPPORTUNITIES TO IMPROVE SYSTOLIC BLOOD PRESSURE CONTROL IN ELDERLY PATIENTS: FOCUS ON INDAPAMIDE SR/AMLODIPINE FIXED DOSE COMBINATIONКотовскаяЮ. В.KotovskayaYu. V.

Котовская Юлия Викторовна — доктор медицинских наук, профессор, заместитель директора по научной работе. 

Москва.

Moscow.

kotovskaya@bk.ruДудинскаяЕ. Н.DudinskayaE. N.

Дудинская Елена Николаевна — кандидат медицинских наук, заведующая лабораторией возрастных метаболических эндокринных нарушений.

Москва.

Moscow.

ТкачеваО. Н.TkachevaO. N.

Ткачева Ольга Николаевна — доктор медицинских наук, профессор, директор. 

Москва.

Moscow.

Федеральное государственное бюджетное образовательное  учреждение высшего образования «Российский  национальный исследовательский медицинский университет  имени Н. И. Пирогова» Министерства здравоохранения  Российской Федерации — «Российский геронтологический  научно-клинический центр».РоссияPirogov Russian National Research Medical University —  Russian Gerontology Clinical Research Center.Russian Federation201812032018241120126Copyright © Котовская Ю.В., Дудинская Е.Н., Ткачева О.Н., 20182018Котовская Ю.В., Дудинская Е.Н., Ткачева О.Н.Kotovskaya Y.V., Dudinskaya E.N., Tkacheva O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/768

Целевое артериальное давление (АД) у пациентов с артериальной гипертензией (АГ) достигается лишь в 30 % случаев. Наиболее сложно достичь эффективного снижения АД у пациентов старших возрастных групп. При этом известно, что систолическое АД (САД) у лиц 55 лет и старше является наиболее сильным прогностическим фактором сердечно-сосудистых осложнений. Эффективными препаратами для снижения САД и пульсового давления (ПД) являются тиазидоподобные диуретики (ТД) и антагонисты кальция (АК). Свое положительное действие препараты доказали и в отношении аортального АД, повышение которого связано с высокой жесткостью артериальной стенки и типично для пожилых людей. Комбинация ТД и АК относится к рекомендуемым согласно современным алгоритмам и руководствам по АГ, однако в связи с отсутствием фиксированной комбинации она не находила широкого клинического применения. Современные данные по эффективности и безопасности индапамида-ретард и амлодипина позволяют утверждать, что их комбинация может стать альтернативным вариантом лечения больных АГ, особенно у пациентов с высоким САД и ПД, у пациентов пожилого возраста и других групп пациентов с высокой жесткостью артериальной стенки.

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The authors declare that there are no conflicts of interest present.