arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2018-24-2-246-256arthyper-798Research ArticleСтатьиArticlesВариабельность артериального давления при артериальной гипертензии в сочетании с ишемической болезнью сердца: прогностическая значимость и возможности коррекции в реальной клинической практикеBlood pressure variability in hypertension associated with coronary heart disease: prognostic value and management approachesОстроумоваО. Д.OstroumovaO. D.

доктор медицинских наук, профессор, профессор кафедры факультетской терапии и профессиональных болезней ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России; профессор кафедры клинической фармакологии и пропедевтики внутренних болезней ФГБОУ ВО «Первый московский государственный медицинский университет им. И. М. Сеченова» Минздрава России

MD, PhD, DSc, Professor, Department for Internal Diseases, A. I. Yevdokimov Moscow State University of Medicine and Dentistry; Professor, Department for Clinical Pharmacology and Propaedeutics of Internal Diseases, Sechenov University

ostroumova.olga@mail.ruКочетковА. И.KochetkovA. I.

кандидат медицинских наук, ассистент кафедры факультетской терапии и профессиональных болезней

MD, PhD, Assistant, Department for Internal Diseases

ak_info@list.ruГусеваТ. Ф.GusevaT. F.

кандидат медицинских наук, доцент кафедры факультетской терапии и профессиональных болезней

MD, PhD, Associate Professor, Department for Internal Diseases

tguseva65@mail.ruФГБОУ ВО Московский государственный медико- стоматологический университет имени А. И. Евдокимова Минздрава России, Москва; ФГАОУ ВО Первый Московский государственный медицинский университет имени И. М. Сеченова Минздрава России, МоскваРоссияA. I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow; Sechenov University, MoscowRussian FederationФГБОУ ВО Московский государственный медико- стоматологический университет имени А. И. Евдокимова Минздрава России, МоскваРоссияA. I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation201815052018242246256Copyright © Остроумова О.Д., Кочетков А.И., Гусева Т.Ф., 20182018Остроумова О.Д., Кочетков А.И., Гусева Т.Ф.Ostroumova O.D., Kochetkov A.I., Guseva T.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/798

В обзоре представлены данные о роли вариабельности артериального давления как нового фактора риска и ее прогностической значимости у пациентов с артериальной гипертензией в сочетании с ишемической болезнью сердца. Рассмотрены современные принципы расчета вариабельности артериального давления, ее классификация. Обсуждаются подходы к дифференцированному выбору антигипертензивных препаратов у больных артериальной гипертензией и ишемической болезнью сердца. Приоритетное внимание уделено возможности применения ингибиторов ангиотензинпревращающего фермента и антагонистов кальция у данной категории пациентов, а также их комбинаций. Приведена доказательная база положительного влияния периндоприла и амлодипина, а также их фиксированной комбинации на вариабельность артериального давления и снижение риска сердечно-сосудистых осложнений при артериальной гипертензии в сочетании с ишемической болезнью сердца, в том числе в реальной клинической практике.

The review discusses the role of blood pressure variability as a novel risk factor and its prognostic value in hypertension associated with the coronary artery disease. We discuss the modern approaches to calculation of blood pressure variability, its classification. The choice of antihypertensive drugs based on the blood pressure variability is discussed considering hypertension associated with coronary artery disease. We pay special attention to angiotensin enzyme converting inhibitors and calcium channel blockers, as well as their combinations. We present the evidence of the effects of perindopril and amlodipine and their fixed combination on the blood pressure variability and the decrease in cardiovascular risk in hypertension associated with coronary artery disease.

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The authors declare that there are no conflicts of interest present.