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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">arthyper</journal-id><journal-title-group><journal-title xml:lang="ru">Артериальная гипертензия</journal-title><trans-title-group xml:lang="en"><trans-title>"Arterial’naya Gipertenziya" ("Arterial Hypertension")</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-419X</issn><issn pub-type="epub">2411-8524</issn><publisher><publisher-name>Antihypertensive League</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/1607-419X-2019-25-6-665-673</article-id><article-id custom-type="elpub" pub-id-type="custom">arthyper-838</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>Влияние частоты сердечных сокращений, приверженности к антигипертензивной фармакотерапии и физическим нагрузкам на течение артериальной гипертензии 1-й степени</article-title><trans-title-group xml:lang="en"><trans-title>The effects of heart rate, adherence to antihypertensive pharmacotherapy and physical exercise on clinical course of first grade hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мангилева</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mangileva</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мангилева Татьяна Александровна — доктор медицинских наук, доцент кафедры внутренней медицины № 1 с курсом клинической фармакологии</p><p>бул. Ленина, д. 5/7, Симферополь, 295051</p></bio><bio xml:lang="en"><p>Tatyana A. Mangileva, MD, PhD, Associate Professor, Internal Medicine Department № 1 with Clinical Pharmacology Course</p><p>5/7 Lenin’s boulevard, Simferopol, 295051</p></bio><email xlink:type="simple">elnego@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Крымский федеральный университет имени В. И. Вернадского»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Crimea Federal University named by V. I. Vernadskiy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>21</day><month>11</month><year>2019</year></pub-date><volume>25</volume><issue>6</issue><fpage>665</fpage><lpage>673</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мангилева Т.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Мангилева Т.А.</copyright-holder><copyright-holder xml:lang="en">Mangileva T.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://htn.almazovcentre.ru/jour/article/view/838">https://htn.almazovcentre.ru/jour/article/view/838</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>прогноз</kwd><kwd>частота сердечных сокращений</kwd><kwd>приверженность к лечению</kwd><kwd>гиперинсулинемия</kwd><kwd>сосудистый эндотелиальный фактор роста</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>prognosis</kwd><kwd>heart rate</kwd><kwd>treatment adherence</kwd><kwd>hyperinsulinemia</kwd><kwd>vascular endothelial growth factor</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С. А., Баланова Ю. А., Шальнова С. А., Деев А. Д., Артамонова Г. В., Гатагонова Т. М. и др. Артериальная гипертония среди лиц 25–64 лет: распространенность, осведомленность, лечение и контроль. По материалам исследования ЭССЕ. Кардиоваскулярная терапия и профилактика. 2014;14(4):4–14. doi: 10.15829/1728-8800-2014-4-4-14.</mixed-citation><mixed-citation xml:lang="en">Boytsov SA, Balanova YuA, Shalnova SA, Deev AD, Artamonova GV, Gatagonova TM et al. Arterial hypertension among individuals of 25–64 years old: prevalence, awareness, treatment and control. By the data from ECCD. Cardiovascular Therapy and Prevention. 2014;14(4):4–14. doi: 10.15829/1728-8800-2014-4-4-14. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ерина А. М., Ротарь О. П., Орлов А. В., Солнцев В. Н., Шальнова С. А., Деев А. Д. и др. Прегипертензия и кардиометаболические факторы риска (по материалам исследования ЭССЕ-РФ). Артериальная гипертензия. 2017;57(3):31–38. doi:10.18705/1607-419X-2017-23-3-243-252.</mixed-citation><mixed-citation xml:lang="en">Erina AM, Rotar OP, Orlov AV, Solntsev VN, Shalnova SA, Deev AD et al. Prehypertension and cardiometabolic risk factors (by the data from ECCD-RF). Arterial’naya Gipertenziya = Arterial Hypertension. 2017;57(3):31–38. doi:10.18705/1607-419X-2017-23-3-243-252. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, Fagard R, Narciewich K, Redon J, Zanchietti A, Bohm M et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens. 2013;31 (7):1281–1357.</mixed-citation><mixed-citation xml:lang="en">Mancia G, Fagard R, Narciewich K, Redon J, Zanchietti A, Bohm M et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens. 2013;31 (7):1281–1357.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Чазова И. Е., Ощепкова Е. В., Жернакова Ю. В., Карпов Ю. А., Архипов М. В., Барбараш О. Л. и др. Диагностика и лечение артериальной гипертонии (Клинические рекомендации). Кардиологический вестник. 2015;10(1):3–10.</mixed-citation><mixed-citation xml:lang="en">Chasova IE, Oshchepkova EV, Zhernakova YuV, Karpov YuA, Arkhipov MV, Barbarash OL et al. Diagnostics and treatment of arterial hypertension (Clinical recommendations). Kardiologicheskiy Vestnik = Cardiological Bulletin. 2015;10(1):3–10. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chobanian AV, Bakris JL, Black HR, Cushman WC, Green LA, Izzo JL et al. The seventh report of the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. J Am Med Assoc. 2003;289(19):1206–1252.</mixed-citation><mixed-citation xml:lang="en">Chobanian AV, Bakris JL, Black HR, Cushman WC, Green LA, Izzo JL et al. The seventh report of the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. J Am Med Assoc. 2003;289(19):1206–1252.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ ACPM/ AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):12691324.</mixed-citation><mixed-citation xml:lang="en">Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ ACPM/ AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):12691324.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrini M. The new European Hypertension guidelines: an evolution if not a revolution [Internet]. Council for cardiology practice. 2018. [cited 04.08.2018]. [Electronic resource]. URL: https://www.escardio.org/Councils/Council-for-Cardiology-Practice-(CCP)/News.</mixed-citation><mixed-citation xml:lang="en">Ferrini M. The new European Hypertension guidelines: an evolution if not a revolution [Internet]. Council for cardiology practice. 2018. [cited 04.08.2018]. [Electronic resource]. URL: https://www.escardio.org/Councils/Council-for-Cardiology-Practice-(CCP)/News.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Щукин Ю. В., Дьячков В. А., Суркова Е. А., Медведева Е. А., Рубаненко А. О. Функциональная диагностика в кардиологии. М.: ГЭОТАР-Медиа, 324 с.</mixed-citation><mixed-citation xml:lang="en">Shchukin IuV, Diachkov VA, Surkova EA, Medvedeva EA, Rubanenko AO. Functional diagnostics in cardiology. M.: GEOTAR-Media, 324 p. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж. Д., Котовская Ю. В., Моисеев В. С. Артериальная гипертензия. Ключи к диагностике и лечению. М.: ГЭОТАР-Медиа, 2009. 864 с.</mixed-citation><mixed-citation xml:lang="en">Kobalava ZhD, Kotovskaya YuV, Moiseev VS. Arterial hypertension the key to diagnosis and treatment. M.: GEOTAR-Media, 2009. 867 p. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Метаболический синдром. Под ред. Г. Е. Ройтберга. М.: МЕДпресс-информ, 2007. 223 с.</mixed-citation><mixed-citation xml:lang="en">Metabolic syndrome. Ed. Roitberg GE. M.: MEDpressinform, 2007. 223 p. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595–1607.</mixed-citation><mixed-citation xml:lang="en">Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595–1607.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Полонецкий Л. З. Значение частоты сердечных сокращений в клинической практике. Новые возможности антиангинальной терапии. Медицинские новости. 2007;5:7–10.</mixed-citation><mixed-citation xml:lang="en">Polonetskiy LZ. Heart rate importance in clinical practice. New capabilities of antianginal therapy. Medical news. 2007;5:7–10. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Сиваков В. П. Показатели частоты сердечных сокращений и вариабельности ритма сердца при артериальной гипертензии: современные представления о методах исследования, клиническом и прогностическом значении. Вестник ВГМК. 2010;1:2–12.</mixed-citation><mixed-citation xml:lang="en">Sivakov VP. Heart rate and heart rate variability in arterial hypertension: modern views about research methods, clinical and prognostic significances. VSMU Bulletin. 2010;1:2–12. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Palatini P, Rosei EA, Casiglia E, Chalmers J, Ferrari R, Grassi G et al. Management of hypertensive patient with elevated heart rate: Statement of the Second Consensus Conference endorsed by the European Society of Hypertension. J Hypertens. 2016; 34 (5):813–821. doi:10.1097/HJH.0000000000000865</mixed-citation><mixed-citation xml:lang="en">Palatini P, Rosei EA, Casiglia E, Chalmers J, Ferrari R, Grassi G et al. Management of hypertensive patient with elevated heart rate: Statement of the Second Consensus Conference endorsed by the European Society of Hypertension. J Hypertens. 2016; 34 (5):813–821. doi:10.1097/HJH.0000000000000865</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Williams B, Mancia G, Spiering W, Rosei EA, Burnei M et al. 2018 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2018; 39(33):3021–3104. doi:10.1093/eurheartj/ehy339</mixed-citation><mixed-citation xml:lang="en">Williams B, Mancia G, Spiering W, Rosei EA, Burnei M et al. 2018 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2018; 39(33):3021–3104. doi:10.1093/eurheartj/ehy339</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Орлов А. В., Ротарь О. П., Бояринова М. А., Демченко Е. А., Конради А. О. Физическая активность — полувековая история. Формирование рекомендаций и поиска методов оценки. Артериальная гипертензия. 2016;22(2):153–159. doi:10.18705/1607-419X-2016-22-2-153-159</mixed-citation><mixed-citation xml:lang="en">Orlov AV, Rotar OP, Boyarinova MA, Demchenko EA, Konradi AO. Physical activity history and development of methodology and guidelines. Arterial’naya Gipertenziya = Arterial Hypertension. 2016;22(2):153–159. doi:10.18705/1607-419X-2016-22-2-153-159. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cornelissen VA, Fagard RH. Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension. 2005;46(4):667–765.</mixed-citation><mixed-citation xml:lang="en">Cornelissen VA, Fagard RH. Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension. 2005;46(4):667–765.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Egginton S. Invited review: activity-induced angiogenesis. Phlugers. Arch. 2009;457(5):963–977. doi:10.1007/s00424-0080563-9</mixed-citation><mixed-citation xml:lang="en">Egginton S. Invited review: activity-induced angiogenesis. Phlugers. Arch. 2009;457(5):963–977. doi:10.1007/s00424-0080563-9</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Neves VJ, Fernandes T, Rogue FR, Soci UP, Melo SF, de Oliveira EM. Exercise training in hypertension: role of microRNAs. World J Cardiol. 2014;6(8):713–727. doi:10.4330/wjc.v6.i8.713</mixed-citation><mixed-citation xml:lang="en">Neves VJ, Fernandes T, Rogue FR, Soci UP, Melo SF, de Oliveira EM. Exercise training in hypertension: role of microRNAs. World J Cardiol. 2014;6(8):713–727. doi:10.4330/wjc.v6.i8.713</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bailey JE, Wan JY, Tang J, Ghani MA, Cushman WC. Antihypertensive medication adherence, ambulatory visits, and risk of stroke and death. J Gen Intern Med. 2010;25(6):495–503. doi:10.1007/s11606-009-1240-1</mixed-citation><mixed-citation xml:lang="en">Bailey JE, Wan JY, Tang J, Ghani MA, Cushman WC. Antihypertensive medication adherence, ambulatory visits, and risk of stroke and death. J Gen Intern Med. 2010;25(6):495–503. doi:10.1007/s11606-009-1240-1</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Калинина А. М., Оганов Р. Г., Небиеридзе Д. В. от имени группы исследователей. Обучение пациентов как фактор эффективного контроля артериальной гипертензии — программа НОКТЮРН. Кардиоваскулярная терапия и профилактика. 2006;5(3):5–14.</mixed-citation><mixed-citation xml:lang="en">Kalinina AM, Oganov RG, Nebieridze DV on behalf of the Working Group. Patients’ education as a factor for arterial hypertension effective control — NOCTURNE Program. Cardiovascular Therapy and Prevention. 2006;5(3):5–14. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Скибицкий В. В., Фендрикова А. В. Эффективность диспергируемой формы периндоприла у пациентов с артериальной гипертензией в клинической практике. Кардиология. 2016;2:19–23. doi:10.18565/cardio.2016.2.19–23</mixed-citation><mixed-citation xml:lang="en">Skibitskiy VV, Fendrikova AV. Efficiency of disperse form of perindopril in patients with arterial hypertension in clinical practice. Kardiologiia. 2016;2:19–23. doi:10.18565/cardio.2016.2.19–23. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Piepoli MF, Hoes AW, Agewall S, Albus Ch, Brotons C, Catapano MT et al. 2016 European guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2016;37 (29):2315–2381. doi:10.1093/eurheartj/ehw106</mixed-citation><mixed-citation xml:lang="en">Piepoli MF, Hoes AW, Agewall S, Albus Ch, Brotons C, Catapano MT et al. 2016 European guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2016;37 (29):2315–2381. doi:10.1093/eurheartj/ehw106</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Viera AJ, Hawes EM. Management of mild hypertension in adults [Internet]. Br Med J. 2016;355: i5719. doi:10.1136/bmj.i5719</mixed-citation><mixed-citation xml:lang="en">Viera AJ, Hawes EM. Management of mild hypertension in adults [Internet]. Br Med J. 2016;355: i5719. doi:10.1136/bmj.i5719</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
