arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2003-9-1-10-13arthyper-865Research ArticleОБЗОРЫREVIEWSКлинические и вазопротективные эффекты аспирина у больных, длительно получающих терапию ингибиторами ангиотензинпревращающего ферментгуThe clinical and vasoprotective effect of aspirin in patients long receiving therapy with angiotensin-converting enzyme inhibitorsСитниковаМ. Ю.SitnikovaM. Yu.noemail@neicon.ruМаксимоваТ. А.MaksimovaT. A.noemail@neicon.ruВахрамееваН. В.VakhrameyevaN. V.noemail@neicon.ruХмельницкаяК. А.KhmelnitskayaK. A.noemail@neicon.ruНаучно-исследовательский институт кардиологии им. В.А. Алмазова Минздрава РФ; СПбГМУ им. акад. И.П.Павлова, Санкт-ПетербургRussian Federation200328022003911013Copyright © Ситникова М.Ю., Максимова Т.А., Вахрамеева Н.В., Хмельницкая К.А., 20032003Ситникова М.Ю., Максимова Т.А., Вахрамеева Н.В., Хмельницкая К.А.Sitnikova M.Y., Maksimova T.A., Vakhrameyeva N.V., Khmelnitskaya K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/865

У 45 мужчин с ишемической болезнью сердца (ИБС) и проявлениями хронической сердечной недостаточности (XCH) в рамках открытого ретроспективного исследования была проведена б-месячная терапия ингибиторами ангиотензинпревращающего фермента (ИАПФ), из них 30 больных на протяжении 6 мес дополнительно получали ацетилсалициловую кислоту в дозе 125 мг в сутки. В динамике оценивали клинические показатели, толерантность к физической нагрузке, данные эхокардиграфического исследования и основные маркеры состояния эндотелия: содержание эндотелина-1 (ЭТ-1), циркулирующих в крови десквамированных эндотелиоцитов (ЦЭК), эндотелийзависимую вазодилатацию, уровень мочевой кислоты, содержание интерлейкина-8 (ИЛ-8). По результатам исследования сделаны выводы о том, что у больных ИБС с проявлениями XCH сопутствующая терапия аспирином не ослабляет основные клинические эффекты ИАПФ и способствует уменьшению функционального класса стенокардии, уменьшению встречаемости парадоксальной вазоконстрикции плечевой артерии. Аспирин в суточной дозе 0,125 ед. не сказывается отрицательно на динамике систолической функции левого желудочка, показателях вазодилатации плечевой артерии, динамике уровней ЭТ-1, ЦЭК, ИЛ-8 и мочевой кислоты в крови, но в то же время умеренно ослабляет гипотензивный эффект ИАПФ.

During an open retrospective study, 6-month therapy with angiotensin-converting enzyme inhibitors (ACEl) was performed in 45 males with coronary heart disease (CHD) and manifestations of chronic heart failure (CHF)1 of them 30 patients additionally received acetyl-salicylic acid in a daily dose of 125 mg. Clinical parameters, exercise tolerance, echocardiographic data and the major endothelial markers: the level of endothelin-1 (ET-1), blood circulating desquamated endotheliocytes (CDE), endothelium-dependent vasodilatation, the level of uric acid, the content of interleukin-8 (1L-8), were followed up. The findings have led to the conclusion that in patients with CHD and manifestations of CHF, contaminant aspirin therapy does not decrease the main clinical effects of ACEl and it contributes to a reduction in the functional class of angina pectoris, in the incidence of paradoxical vasoconstriction of the brachial artery. Aspirin in a daily dose of 0.12 5 fails to have a negative effect on the variations of left ventricular systolic function, on the parameters of brachial vasodilatation, on the changes in the blood levels of ET-1, CDE, 1L-8, and uric acid, but moderately decreases the antihypertensive effect of ACEI at the same time.

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The authors declare that there are no conflicts of interest present.