arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2003-9-6-221-224arthyper-903Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВлияние фиксированной низкодозовой комбинации гипотензивных препаратов на клинико-биохимические характеристики больных артериальной гипертензиейEffect of a small-dose combination of antihypertensive agents on the clinical and biochemical characteristics of patients with arterial hypertensionГалееваЗ. М.GaleyevaZ. M.noemail@neicon.ruГалявичА. С.GalyavichA. S.noemail@neicon.ruКазанский государственный медицинский университетRussian Federation20032812200396221224Copyright © Галеева З.М., Галявич А.С., 20032003Галеева З.М., Галявич А.С.Galeyeva Z.M., Galyavich A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/903

Обследованы 40 пациентов с АГ I-II степени, После 2-недельного контрольного периода больным с целью коррекции повышенного артериального давления (АД) назначали нолипрел (низкодозовая комбинация ингибитора ангио-тензинпревращающего фермента периндоприла и диуретика ипдапамида) в дозе 1 таблетка утром. Курс лечения составил 3 мес. Дополнительной терапии не проводили. Оценивали степень снижения АД, % больных, нормализовавших уровень АД, а также клиническую и биологическую переносимость лечения. Низкодозовая комбинация периндоприла и ипдапамида подтвердила высокую гипотензивную эффективность (достоверное снижение систолического и диастолического АД, пульсового и среднего АД, у 8036 больных нормализовался уровень АД в течение 3 мес, причем у большинства из них в течение 1-го месяца лечения). Нолипрел подтвердил свою хорошую клиническую и биологическую переносимость.

Forty patients with stages I-II arterial hypertension (AH) were examined. After a two-week control period, the patients were given Noliprel (a small-dose combination of perindopril and the diuretic indapamidе) in a dose of 1 tablet in the morning to correct elevated blood pressure (BP). The course of therapy lasted 3 months. No additional therapy was performed. The level of CB lowering, the proportion of the patients in whom BP became normal, as well as the clinical and biological tolerance of the therapy were estimated. The small-dose combination of perindopril and indapamidе showed its high antihypertensive efficacy (significant reductions in systolic, diastolic, and mean arterial BP; BP was normalized in 80 % of the patients within 3 months, in most patients within the first month of treatment). Noliprel proved to be well clinically and biologically tolerated.

артериальная гипертензияфиксированная низкодозовая комбинацияarterial hypertensionfixed small-dose combinationReferencesCarretero О.А., Oparil S. Essential hypertension. Part definition and etiology: Circulation 2000; 101: 329 - 35.Carretero О.А., Oparil S. Essential hypertension. Part definition and etiology: Circulation 2000; 101: 329 - 35.Carretero O.A., Oparil S. Essential Hypertension, Part II: treatment: Circulation 2000: 101: 446 - 453.Carretero O.A., Oparil S. Essential Hypertension, Part II: treatment: Circulation 2000: 101: 446 - 453.Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The Seventh Report of the Joint National Commitee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-VII). JAMA May 21, 2003: 289 (19):Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The Seventh Report of the Joint National Commitee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-VII). JAMA May 21, 2003: 289 (19):Hansson L., Zanchetti A., Carruthers S.G. et al. Effects of intensive blood pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomized Mai. Lancet 1998: 351: 1755 - 62.Hansson L., Zanchetti A., Carruthers S.G. et al. Effects of intensive blood pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomized Mai. Lancet 1998: 351: 1755 - 62.Herpin D., Mallion J.M., Benkritly A. et al. Elude HOT: efficacite et tolerance a 36 mois. Arch Mai Coeur Vaiss 1998: 91: 1043 - 8.Herpin D., Mallion J.M., Benkritly A. et al. Elude HOT: efficacite et tolerance a 36 mois. Arch Mai Coeur Vaiss 1998: 91: 1043 - 8.Staessen J.A., Fagard R., Thijs L. et al., for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet 1997: 350: 757 – 64.Staessen J.A., Fagard R., Thijs L. et al., for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet 1997: 350: 757 – 64.Wiklund I., Halling K. Ruden-Betgslen T., Fletcher A. on behalf of the HOT Study Group. Does lowering the blood pressure improve the mood Quality of life results front the Hupertension Optimal Treatment (HOT) Study. Blood Pressure 1997; 6: 357 - 64.Wiklund I., Halling K. Ruden-Betgslen T., Fletcher A. on behalf of the HOT Study Group. Does lowering the blood pressure improve the mood Quality of life results front the Hupertension Optimal Treatment (HOT) Study. Blood Pressure 1997; 6: 357 - 64.Sever PJ. Cardiovasc Pharmacol 1998:31 (suppl. 2): S. 1 -4.Sever PJ. Cardiovasc Pharmacol 1998:31 (suppl. 2): S. 1 -4.European Society of Hypertension - European Society of Cardiology. Guidelines for the management of arterial Hypertension. Guidekines Committee./ of Hypertension 2003: 21: 1011 - 53.European Society of Hypertension - European Society of Cardiology. Guidelines for the management of arterial Hypertension. Guidekines Committee./ of Hypertension 2003: 21: 1011 - 53.Castaigne A., Chalmers J., Morgan T. et al. Efficacy and safe!)' of an oral fixed low-doze perindopril 2 mg / indapamid 0,625 mg combination: a randomized, double-blind, placebo-controlled study in elderly patients with mild-to-moderate hypertension. Clin Exper Hypertens 1999: 21 (7): 1097 - 110.Castaigne A., Chalmers J., Morgan T. et al. Efficacy and safe!)' of an oral fixed low-doze perindopril 2 mg / indapamid 0,625 mg combination: a randomized, double-blind, placebo-controlled study in elderly patients with mild-to-moderate hypertension. Clin Exper Hypertens 1999: 21 (7): 1097 - 110.Chalmers J., Castaigne A., Morgan T., Chastang С. Long term efficacy of a new fixed very low dose angiotensin-converting enzyme-inhibitor / diuretic combination as first line therapy in elderly hypertensive patients. J Hypertens 2000; 18: 327-37.Chalmers J., Castaigne A., Morgan T., Chastang С. Long term efficacy of a new fixed very low dose angiotensin-converting enzyme-inhibitor / diuretic combination as first line therapy in elderly hypertensive patients. J Hypertens 2000; 18: 327-37.Chanudet X., Phong Chau N., De Champvallins M. Very-low-dose perindopril 2 mg / indapamide 0,625 mg combination gives ligher response ami normalization rules than losarlan 50 mg in the treatment of essential hypertension. Am J Hypertension 2000; 4: 140.Chanudet X., Phong Chau N., De Champvallins M. Very-low-dose perindopril 2 mg / indapamide 0,625 mg combination gives ligher response ami normalization rules than losarlan 50 mg in the treatment of essential hypertension. Am J Hypertension 2000; 4: 140.Mallion J.M., Chastang С., Unger P. Efficacy and safety of a fixed low-dose perindopril / indapamide combination in essential hypertension: a randomised controlled study. Clin Exp Hypertens 2000: 22: 23-32.Mallion J.M., Chastang С., Unger P. Efficacy and safety of a fixed low-dose perindopril / indapamide combination in essential hypertension: a randomised controlled study. Clin Exp Hypertens 2000: 22: 23-32.Neaton J.D., Wentworth, for the Multiple Risk intervention Trial Research Group. Serum cholesterol, blood pressure, sigarette smoking and death from coronary heart disease: overall findings and differences by age for316099 white men. Arch Intern Med 1992: 23: 275 - 85.Neaton J.D., Wentworth, for the Multiple Risk intervention Trial Research Group. Serum cholesterol, blood pressure, sigarette smoking and death from coronary heart disease: overall findings and differences by age for316099 white men. Arch Intern Med 1992: 23: 275 - 85.Myers M.G., Asmar R., Leenen E.H., Safar M. Fixed low-doze combination therapy In hypertension - a doze response study of perindopril and indapamid. J Hypertens 2000; 18: 317 - 25.Myers M.G., Asmar R., Leenen E.H., Safar M. Fixed low-doze combination therapy In hypertension - a doze response study of perindopril and indapamid. J Hypertens 2000; 18: 317 - 25.SHEP Cooperative Research Group. Prevention of stroke lyy antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991; 265: 3255 - 64.SHEP Cooperative Research Group. Prevention of stroke lyy antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991; 265: 3255 - 64.De Luca N., SafarM.E. Efficacy of a very-low-dose perindopril 2 mg / indapamide 0,625 mg on cardiac hypertrophy in hypertensive patients. J Hypertens 2002; 20 (4).De Luca N., SafarM.E. Efficacy of a very-low-dose perindopril 2 mg / indapamide 0,625 mg on cardiac hypertrophy in hypertensive patients. J Hypertens 2002; 20 (4).Benetos A., Safar M., RudnichiA., Smulyan H. el al. Pulse pressure: a predictor of long-term cardiovascular mortality in a French male population. Hypertension 1997; 30: 1410-5.Benetos A., Safar M., RudnichiA., Smulyan H. el al. Pulse pressure: a predictor of long-term cardiovascular mortality in a French male population. Hypertension 1997; 30: 1410-5.Madhavan S., Ooi W.L., Alderman M.N. Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarction. Hypertension 1994; 23: 395-401.Madhavan S., Ooi W.L., Alderman M.N. Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarction. Hypertension 1994; 23: 395-401.Mogensen C.E., Viberti G., Halimi S. et al. Treatment based on low-dose combination of perindopril and indapamide reduces albuminuria more effectively than enalapril in hypertensive type 2 diabetic patients. Am J Hypertens 2002; 15: 21A - 22A.Mogensen C.E., Viberti G., Halimi S. et al. Treatment based on low-dose combination of perindopril and indapamide reduces albuminuria more effectively than enalapril in hypertensive type 2 diabetic patients. Am J Hypertens 2002; 15: 21A - 22A.

The authors declare that there are no conflicts of interest present.