arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2003-9-6-225-228arthyper-904Research ArticleНОВОСТИ КЛИНИЧЕСКИХ ИССЛЕДОВАНИЙО значении для клинической практики результатов исследований INSIGHT и ENCORValue of the results of INSIGHT and ENCOR studies for clinical practiceХирмановВ. Н.KhirmanovV. N.noemail@neicon.ruСанкт-Петербургская государственная медицинская академия им. И.И.МечниковаRussian Federation20032812200396225228Copyright © Хирманов В.Н., 20032003Хирманов В.Н.Khirmanov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/904

Представлены новейшие данные о клинической эффективности и безопасности применения пролонгированного лекарственного препарата из группы антагонистов медленных кальциевых каналов ОСМО-адалата (нифедипин ГИТС). Помимо выраженного и стойкого гипотензивного эффекта при монотерапии ОСМО-адалатом, при многолетием применении отмечено значительное снижение частоты основных сердечно-сосудистых осложнений, включая смертельные, в частности, и у больных, ранее перенесших инфаркт миокарда. Гипотензивный эффект этого препарата не уступал таковому при использовании стандартной терапии мочегонным средством. Однако ОСМО-адалат более благоприятно воздействовал на метаболизм углеводов, липидов и мочевой кислоты, при его применении реже возникали окклюзии периферический артерий, подагра и сахарный диабет. Установлено, что применение этого препарата предотвращало увеличение толщины интимо-медиального слоя сонных артерий и препятствовало прогрессированию кальциноза коронарных артерий (применение диуретика не препятствовало этому). Кроме того, в исследовании ENCOR было выявлено, что терапия ОСМО-адалатом приводит к предотвращению спастических реакций в коронарных артериях в связи с улучшением в них функции эндотелия.

The paper presents the latest data on the clinical efficacy and safety of OSMO adalate (Nifedepine GITS), a lomg-acting drug from a group of slow calcium channel blockers. In addition to its pronounced and steady-state antihypertensive effect during monotherapy, OSMO adalate, when long used, causes a significant reduction in the incidence of cardiovascular complications, including fatal events in particular, and in patients with prior myocardial infarction. The antihypertensive effect of this drug is not inferior to that of the routine diuretic therapy. However, OSMO adalate more favorably affects the metabolism of carbohydrates, lipids, and uric acid and less frequently induced peripheral arterial oclusions, gout, and diabetes mellitus. The use of this drug has been found to prevent an increase in the thickness of carotid intimomedial layers, as well as progression of coronary arterial calcinosis (the use of a diuretics does not). Moreover, the ENCOR study has revealed that OSMO adalate therapy also prevents spastic reactions in the coronary arteries due to their better endothelial function.

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The authors declare that there are no conflicts of interest present.