arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2004-10-2-126-130arthyper-927Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESСравнение влияния терапии рилменидином и атенололом на состояние барорефлекторной регуляции кровообращения у больных гипертонической болезнью: связь с суточным профилем артериального давления и выраженностью антигипертензивного эффектаImpact of therapy with rilmedinine versus atenolol on baroreflectory circulatory regulation in patients with hypertensive disease: association with the diurnal profile of blood pressure profile and the magnitude of antihypertensive effectМамонтовО. В.MamontovO. V.noemail@neicon.ruКашерининовЮ. Р.KasherininovYu. R.noemail@neicon.ruШаваровА. А.ShavarovA. A.noemail@neicon.ruКонрадиА. О.KonradiA. O.konradi@almazovcentre.ruИнститут сердечно-сосудистых заболеваний СП6ГМУ им. акад. И.П. ПавловаRussian Federation200428042004102126130Copyright © Мамонтов О.В., Кашерининов Ю.Р., Шаваров А.А., Конради А.О., 20042004Мамонтов О.В., Кашерининов Ю.Р., Шаваров А.А., Конради А.О.Mamontov O.V., Kasherininov Y.R., Shavarov A.A., Konradi A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/927

Актуальность. Механизмы реализации антигипертензивного эффекта селективных агонистов имидазолиновых рецепторов,таких как рилменидин, в настоящее время остаются недостаточно изученными. Улучшение барорефлекторной регуляции системы кровообращения при лечении антигипертензивными препаратами создает дополнительные преимущества в отношении прогноза дальнейшего прогрессирования заболевания у больных гипертонической болезнью. Цель исследования. Оценка динамики вазомоторного компонента кардиопульмонального барорефлекса (КПБР) в острой пробей на фоне длительной терапии рилменидином в сравнительном исследовании с атенололом и научение влияния изменения барорефлекторной регуляции на эффективность последующей терапии. Результаты. В целом по данным суточного мониторирования, на фоне длительной терапии в обеих группах наблюдалось достоверное снижение артериального давления, у пациентов через 2 ч после приема рилменидина отмечена разнонаправленная динамика вазомоторного компонента КПБР, изменчивость которого была связана с эффективностью последующей шестимесячной терапии этим препаратом, которая оценивалась по степени снижения уровня и вариабельности АД, а также по восстановлению суточного профиля артериального давления.

Background. The mechanisms responsible for the antihypertensive effect of selective imidazoline receptor agonists, such as rilmedinine, remain nowadays inadequately explored, improved baroreflectory regulation of the circulatory system in the treatment with antihypertensive drugs makes additional advantages in predicting further progression in patients with hypertensive disease. Aim. To estimate the time course of changes in the vasomotor component of cardiopulmonary baroreflex (CPBR) during acute and chronic therapy with rilmenidine versus atenolol and to study the impact of baroreflectory regulation on the efficiency of further therapy. Results. According to the data of daily monitoring, long-term therapy showed a significant decrease in blood pressure in both groups. Two hours after the use of rilmenidine, the patients showed a heterodirectional changes in the vasomotor component of CPBR whose variability was associated with the efficiency of further 6-month therapy with this drug, which was evaluated by the decrease of the level and variability of the diurnal blood pressure profile, and by the fattens recovery.

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The authors declare that there are no conflicts of interest present.