arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2004-10-4-194-196arthyper-941Research ArticleСтатьиArticlesВлияние инсерционно-делеционного полиморфизма гена ангиотензинпревращающего фермента на развитие, прогрессирование и эффективность терапии диабетической нефропатии у больных сахарным диабетом типа 1Impact of insertion-deletion polymorphism of angiotensin-convcrting enzyme gene on the development and progression of diabetic nephropathy and efficiency of its therapy in patients with type 1 diabetes mellitusШуцкаяЖ. В.ShutskayaZh. V.zhanna_shuckaya@mail.ruЕгороваО. О.YegorovaO. O.noemail@neicon.ruНадьЮ. Г.NadYu. Ci.noemail@neicon.ruСтройковаА. С.StroikovaA. S.noemail@neicon.ruПапаянА. В.PapayanA. V.noemail@neicon.ruШварцЕ. И.ShvartsYe. I.noemail@neicon.ruСанкт-Петербургская государственная педиатрическая медицинская академияRussian Federation200428082004104194196Copyright © Шуцкая Ж.В., Егорова О.О., Надь Ю.Г., Стройкова А.С., Папаян А.В., Шварц Е.И., 20042004Шуцкая Ж.В., Егорова О.О., Надь Ю.Г., Стройкова А.С., Папаян А.В., Шварц Е.И.Shutskaya Z.V., Yegorova O.O., Nad Y.C., Stroikova A.S., Papayan A.V., Shvarts Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/941

Задачами нашего исследования явились изучение ассоциации инсерционно-делеционного (I/D) полиморфизма гена АПФ с развитием и прогрессированием диабетической нефропатии (ДН), а также установление взаимосвязи различных аллельных вариантов данного генетического полиморфизма и эффективности снижения микроальбуминурии (МАУ) при терапии каптоприлом больных с начинающейся ДН. При изучении I/D-полиморфизма гена АПФ не выявлено статистических различий в распределении генотипов и аллелей в группе больных с ДН (п = 47) и без ДН (п = 79). Однако обнаружена достоверно более высокая частота встречаемости D-аллеля у больных с поздними стадиями ДМ (выраженной нефропатии и уремии) по сравнению с пациентами с ранней стадией ДН - МАУ (p<0,05). Выявленная закономерность может свидетельствовать, что присутствие D-аллеля в структуре гена ЛПФ является одним из маркеров прогрессирования диабетического поражения почек у больных СД типа 1. Терапия больных с начинающейся ДН (п = 13) каптоприлом в течение 1 месяца приводит к статистически достоверному снижению МАУ. При этом нами не выявлено достоверных различий в группах пациентов с различными аллельными вариантами гена АПФ.

The study was undertaken to examine the association of the insertion-detection (ID) polymorphism of angiotensin-converting enzyme (ACE) gene with the development and progression oJ diabetic nephropathy (DN) and to establish a relationship of different allele types of genetic- polymorphism to the efficiency of microalbuminuria (MAU) diminution in captopril-treated patients with evolving DN. The study of the I/D polymorphism of ACE gene revealed no statistical differences in the distribution of genotypes and alleles in the group of patients with (n = 17) and without (n = 79) DN. However, the significantly higher frequency of D allele was found in patients with end-stage DN (significant nephropathy and uremia) as compared with those of early-stage DN (MAU) (p<0,05). The revealed regularity may suggest that the presence of D allele in the structure of ACE gene is one of the markers of progression of diabetes-induced renal lesion in patients with type I diabetes mellitus One-month captopril therapy in patients with evolving DN (n = l3) causes a statistically significant decrease in MAU. At the same time, there were no significant differences in the group of patients with different allele genotypes of ACE.

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The authors declare that there are no conflicts of interest present.