arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2004-10-1-23-25arthyper-954Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESФокальные повреждения белого вещества головного мозга у больных артериальной гипертонией по данным 5-летнего проспективного исследованийFocal lesions of the cerebral white matter in patients with arterial hypertension as evidenced by 5-year prospective studyМордовинВ. Ф.MordovinV. F.noemail@neicon.ruДфанасьеваН. Л.AfanasyevaN. L.noemail@neicon.ruЛукьяненокП. И.LukyanenokP. I.noemail@neicon.ruСемкеГ. В.SemkeG. V.noemail@neicon.ruНИИ кардиологии ТНЦ СО РАМНRussian Federation2004280220041012325Copyright © Мордовин В.Ф., Дфанасьева Н.Л., Лукьяненок П.И., Семке Г.В., 20042004Мордовин В.Ф., Дфанасьева Н.Л., Лукьяненок П.И., Семке Г.В.Mordovin V.F., Afanasyeva N.L., Lukyanenok P.I., Semke G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/954

Исследования выполнены у 58 больных артериальной гипертонией (33 мужчины и 25 женщин в возрасте от 36 до 59 лет). Как исходно, так и повторно через 5 лет, всем пациентам проводили суточное мониторирование артериального давления (АД) н магнитно-резонансную томографию головного мозга. Отмечено, что у 15(25%) пациентов появились фокальные повреждения белого вещества головного мозга (ФПБВ), ранее отсутствовавшие, у 12 (21 %) человек (ФПБВ) остались без динамики, у 17 (30%) человек отмечено увеличение количества ФПБВ. В группе пациентов, у которых появились ФПБВ, были достоверно выше исходные показатели АД и его временные индексы, при повторном исследовании были достоверно выше только временные индексы АД. Полученные данные свидетельствуют, что артериальная гипертония является одним из факторов, повышающих вероятность возникновения ФПБВ и применение метода суточного мониторирования АД позволяет выделить группу больных с повышенным риском их появления.

Studies were conducted in 58 patients (33 males and 25 females) aged 36 to 59 years who had arterial hypertension. 24-hour blood pressure (BP) monitoring and brain magnetic resonance imaging were performed in all the patients before and 5 years after the studies. Focal cerebral white matter lesions (FCWML) that had been absent before was found to appear in 15 (25%) patients; FCWML showed no changes in 12 (21%) patients. There was an increase in the number of FCWML in 17 (30%). The patients in whom FCWML appeared had significantly higher baseline values of BP and its time indices and, on repeated examination, they had only significantly higher time indices of BP. The findings suggest that arterial hypertension is a factor that enhances the likelihood of GCWML and that the use of 24-hour BP monitoring permits identification of a group of patients having a high risk for their appearance.

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The authors declare that there are no conflicts of interest present.