arthyperАртериальная гипертензия"Arterial’naya Gipertenziya" ("Arterial Hypertension")1607-419X2411-8524Antihypertensive League10.18705/1607-419X-2013-19-4-203-213arthyper-99Research ArticleОБЗОРREVIEWВНУТРИУТРОБНОЕ ГОЛОДАНИЕ И РИСК АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ И СЕРДЕЧНО-СОСУДИСТЫХ ОСЛОЖНЕНИЙINTRAUTERINE UNDERNUTRITION AND HYPERTENSION AND CARDIOVASCULAR RISKМогучаяЕ. В.MoguchayaE. V.

Научный сотрудник научно-исследовательской лаборатории эпидемиологии артериальной гипертензии ФЦСКЭ им. В.А. Алмазова

konradi@almazovcentre.ruРотарьО. П.RotarO. P.

Кандидат медицинских наук, заведующая научно-исследовательской лабораторией эпидемиологии артериальной гипертензии ФЦСКЭ им. В.А. Алмазова

konradi@almazovcentre.ruКонрадиА. О.KonradiA. O.

Доктор медицинских наук, профессор, руководитель научно-исследовательского отдела артериальной гипертензии, заместитель директора по научной работе ФЦСКЭ им. В.А. Алмазова.

Контактная информация: ФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Министерства здравоохранения Российской Федерации, ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341. Тел.: 8 (812) 702–37–33.  E-mail: konradi@almazovcentre.ru (Конради Александра Олеговна).

Corresponding author: Almazov Federal Heart, Blood and Endocrinology Centre, 2 Akkuratov st., St Petersburg, Russia, 197341.  Phone: 8 (812) 702–37–33. E-mail: konradi@almazovcentre.ru (Aleksandra O. Konradi, MD, PhD, Professor, the Head of the Department of Hypertension, the Deputy Research Director of Almazov Federal Heart, Blood and Endocrinology Centre).

konradi@almazovcentre.ruФедеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова, Санкт-ПетербургРоссияAlmazov Federal Heart, Blood and Endocrinology Centre, St Petersburg, RussiaRussian Federation201328082013194299304Copyright © Могучая Е.В., Ротарь О.П., Конради А.О., 20132013Могучая Е.В., Ротарь О.П., Конради А.О.Moguchaya E.V., Rotar O.P., Konradi A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://htn.almazovcentre.ru/jour/article/view/99

В обзоре представлены данные исследований, касающихся отдаленных последствий голода, перенесенного во внутриутробном периоде с позиций сердечно-сосудистого риска. Приводятся описание и результаты наблюдения за основными популяциями лиц, рожденных в период голода вследствие войны и стихийных бедствий.

The paper reviews the data of observational studies concerning effects of famine during untrauterine development and long-term outcome and cardiovascular risk. The overview and results of the major cohorts of subjects born during famine due to wars and other historical events are described. 

голодзадержка внутриутробного развитияартериальная гипертензиясердечно-сосудистый рискfamineuntrauterine growth retardationhypertensioncardiovascular riskReferencesBarker D.J., Eriksson J.G., Forsen T., Osmond C. Fetal origins of adult disease: strength of effects and biological basis // Int. J. Epidemiol. — 2002. — Vol. 31, № 6. — P. 1235–1239.Barker D.J., Eriksson J.G., Forsen T., Osmond C. Fetal origins of adult disease: strength of effects and biological basis // Int. J. Epidemiol. — 2002. — Vol. 31, № 6. — P. 1235–1239.Bateson P., Barker D., Clutton-Brock T. et al. Developmental plasticity and human health // Nature. — 2004. — Vol. 430, № 6998. — P. 419–421.Bateson P., Barker D., Clutton-Brock T. et al. Developmental plasticity and human health // Nature. — 2004. — Vol. 430, № 6998. — P. 419–421.Barker D.J. The fetal and infant origins of adult disease // Br. Med. J. — 1990. — Vol. 301, № 6761. — P. 1111.Barker D.J. The fetal and infant origins of adult disease // Br. Med. J. — 1990. — Vol. 301, № 6761. — P. 1111.Nilsson P.M., Laurent L.E. The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome // J. Hypertens. — 2008. — Vol. 26, № 6. — P. 1049–1047.Nilsson P.M., Laurent L.E. The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome // J. Hypertens. — 2008. — Vol. 26, № 6. — P. 1049–1047.Ravelli A.C.J., van der Meulen J.H.P., Michels R.P.J. et al. Glucose tolerance in adults after in utero exposure to the Dutch Famine // Lancet. — 1998. — Vol. 351, № 9097. — P. 173–177.Ravelli A.C.J., van der Meulen J.H.P., Michels R.P.J. et al. Glucose tolerance in adults after in utero exposure to the Dutch Famine // Lancet. — 1998. — Vol. 351, № 9097. — P. 173–177.Roseboom T.J., van der Meulen J.H.P., Osmond C. et al. Lipid proile after prenatal exposure to the Dutch famine 1944–1945 // Am. J. Clin. Nutr. — 2000. — Vol. 72, № 5. — Р. 1101–1106.Roseboom T.J., van der Meulen J.H.P., Osmond C. et al. Lipid proile after prenatal exposure to the Dutch famine 1944–1945 // Am. J. Clin. Nutr. — 2000. — Vol. 72, № 5. — Р. 1101–1106.Ravelli A.C.J., van der Meulen J.H.P., Osmond C., Barker D.J., Bleker O.P. Obesity at the age of 50 y in men and women exposed to famine prenatally // Am. J. Clin. Nutr. — 1999. — Vol. 70, № 5. — P. 811–816.Ravelli A.C.J., van der Meulen J.H.P., Osmond C., Barker D.J., Bleker O.P. Obesity at the age of 50 y in men and women exposed to famine prenatally // Am. J. Clin. Nutr. — 1999. — Vol. 70, № 5. — P. 811–816.Roseboom T., de Rooij S., Painter R. The Dutch famine and its long-term consequences for adult health // Early Hum. Dev. — 2006. — Vol. 82, № 8. — P. 485–491.Roseboom T., de Rooij S., Painter R. The Dutch famine and its long-term consequences for adult health // Early Hum. Dev. — 2006. — Vol. 82, № 8. — P. 485–491.Abeelen A., Elias S.G., Diederick E. et al. Cardiovascular consequences of famine in the young // Eur. Heart J. — 2012. — Vol. 33, № 4. — P. 538–545.Abeelen A., Elias S.G., Diederick E. et al. Cardiovascular consequences of famine in the young // Eur. Heart J. — 2012. — Vol. 33, № 4. — P. 538–545.De Rooij W.H., Sr, Yonker J.E., Painter R.C., Roseboom T.J. Prenatal undernutrition and cognitive function in late adulthood // Proc. Natl. Acad. Sci. USA. — 2010. — Vol. 107, № 39. — Р. 16881–16886.De Rooij W.H., Sr, Yonker J.E., Painter R.C., Roseboom T.J. Prenatal undernutrition and cognitive function in late adulthood // Proc. Natl. Acad. Sci. USA. — 2010. — Vol. 107, № 39. — Р. 16881–16886.Dandrea J. et al. Maternal nutritional manipulation of placental growth and glucose transporter 1 (GLUT-1) abundance in sheep // Reproduction. — 2001. — Vol. 122, № 5. — P. 793–800.Dandrea J. et al. Maternal nutritional manipulation of placental growth and glucose transporter 1 (GLUT-1) abundance in sheep // Reproduction. — 2001. — Vol. 122, № 5. — P. 793–800.Desai M., Hales C.N. Role of fetal and infant growth in programming metabolism in later life // Biol. Rev. Camb. Philos Soc. — 1997. — Vol. 72, № 2. — P. 329–348.Desai M., Hales C.N. Role of fetal and infant growth in programming metabolism in later life // Biol. Rev. Camb. Philos Soc. — 1997. — Vol. 72, № 2. — P. 329–348.Oliver M.H., Hawkins P., Harding J.E. Periconceptional undernutrition alters growth trajectory and metabolic and endocrine responses to fasting in late gestation fetal sheep // Pediatr. Res. — 2005. — Vol. 57, № 4. — P. 591–598.Oliver M.H., Hawkins P., Harding J.E. Periconceptional undernutrition alters growth trajectory and metabolic and endocrine responses to fasting in late gestation fetal sheep // Pediatr. Res. — 2005. — Vol. 57, № 4. — P. 591–598.Bispham J., Gopalakrishnan G.S., Dandrea J. et al. Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and theprogramming of fetal adipose tissue development // Endocrinology. — 2003. — Vol. 144, № 8. — P. 3575–3585.Bispham J., Gopalakrishnan G.S., Dandrea J. et al. Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and theprogramming of fetal adipose tissue development // Endocrinology. — 2003. — Vol. 144, № 8. — P. 3575–3585.Pavlov D. Leningrad 1941: the blockade. — Chicago: University of Chicago Press, 1965. — 186 p.Pavlov D. Leningrad 1941: the blockade. — Chicago: University of Chicago Press, 1965. — 186 p.Sparen P., Vagero D., Shestov D.B. Long term mortality after severe starvation during the siege of Leningrad: prospective cohort study // Br. Med. J. — 2004. — Vol. 328, № 7430. — P. 11.Sparen P., Vagero D., Shestov D.B. Long term mortality after severe starvation during the siege of Leningrad: prospective cohort study // Br. Med. J. — 2004. — Vol. 328, № 7430. — P. 11.Stanner S.A., Bulmer K., Andres C. et al. Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study // Br. Med. J. — 1997. — Vol. 315, № 7119. — P. 1342–1348.Stanner S.A., Bulmer K., Andres C. et al. Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study // Br. Med. J. — 1997. — Vol. 315, № 7119. — P. 1342–1348.Huang C., Zhu Li Z., Wang M., Martorell R. Early life exposure to the 1959–1961 Chinese famine has long-term health consequences // J. Nutr. — 2010. — Vol. 140, № 10. — P. 1874–1878.Huang C., Zhu Li Z., Wang M., Martorell R. Early life exposure to the 1959–1961 Chinese famine has long-term health consequences // J. Nutr. — 2010. — Vol. 140, № 10. — P. 1874–1878.Hult M., Tornhammar P., Umda P. et al. Hypertension, diabetes and overweight: looming legacies of the Biafran famine // PLoS ONE. — 2010. — Vol. 5, № 10. — ID: e13582.Hult M., Tornhammar P., Umda P. et al. Hypertension, diabetes and overweight: looming legacies of the Biafran famine // PLoS ONE. — 2010. — Vol. 5, № 10. — ID: e13582.Razzaque A., Alam N., Wai L., Foster A. Sustained effects of the 1974–75 famine on infant and child mortality in a rural area of Bangladesh // Popul. Stud. (Camb). — 1990. — Vol. 44, № 1. — P. 145–154.Razzaque A., Alam N., Wai L., Foster A. Sustained effects of the 1974–75 famine on infant and child mortality in a rural area of Bangladesh // Popul. Stud. (Camb). — 1990. — Vol. 44, № 1. — P. 145–154.Christensen K.K., Vaupel J.W. No increased mortality in later life for cohorts born during famine //Am. J. Epidemiol. — 1997. — Vol. 145, № 11. — Р. 987–994.Christensen K.K., Vaupel J.W. No increased mortality in later life for cohorts born during famine //Am. J. Epidemiol. — 1997. — Vol. 145, № 11. — Р. 987–994.Hypponen E., Leon D.A., Kenward M.G., Lithell H. Prenatal growth and risk of occlusive and haemorrhagic stroke in Swedish men and women born 1915 29: historical cohort study // Br. Med. J. — 2001. — Vol. 323, № 7320. — P. 1033–1034.Hypponen E., Leon D.A., Kenward M.G., Lithell H. Prenatal growth and risk of occlusive and haemorrhagic stroke in Swedish men and women born 1915 29: historical cohort study // Br. Med. J. — 2001. — Vol. 323, № 7320. — P. 1033–1034.Szostak-Wegierek D., Szamotulska K. Fetal development and risk of cardiovascular diseases and diabetes type 2 in adult life // Med. Wieku Rozwoj. — 2011. — Vol. 15, № 3. — P. 203–215.Szostak-Wegierek D., Szamotulska K. Fetal development and risk of cardiovascular diseases and diabetes type 2 in adult life // Med. Wieku Rozwoj. — 2011. — Vol. 15, № 3. — P. 203–215.

The authors declare that there are no conflicts of interest present.