UP-TO-DATE VIEW AT THE ROLE OF ASEPTIC INFLAMMATION OF ADIPOSE TISSUE IN THE GENESIS OF OBESITY AND METABOLIC SYNDROME
https://doi.org/10.18705/1607-419X-2013-19-4-
Abstract
Over the past two decades the views at the role of adipose tissue in the metabolic and energy metabolism have radically changed. There have appeared more and more evidence on the production of biologically active substances by adipose tissue, the so-called adipocytokines that are involved in the regulation of metabolic processes at the local or systemic level, of the tissue sensitivity to insulin, as well as pro-inlammatory or anti-inlammatory effect. By analysing the relationship and interaction of abdominal obesity, aseptic inlammation of adipose tissue and insulin resistance, it should be emphasized that these processes operate on the principle of mutual reinforcement, forming a vicious circle. Further understanding of adipokines and cytokines participation in the development of obesity and metabolic syndrome may contribute to a deeper insight into their biological role.
About the Authors
N. N. Kryukov
Samara State Medical University, Samara
Russian Federation
Russian Federation
M. M. Ginzburg
Samara State Medical University, Samara
Russian Federation
Russian Federation
E. V,. Kiseleva
Samara State Medical University, Samara
Russian Federation
Russian Federation
Corresponding author: Samara State Medical University, 13 Aksakov st., Samara, Russia, 443030. E-mail: kisel@live.com (Elena V. Kiseleva, Senior Assistant at the Department of Internal Medicine at Samara State Medical University).
References
1. World Health Organization. Fact sheets. — 2013. [Electronic resourse]. — URL: http://www.who.int/mediacentre/factsheets/.
2. Драпкина О.М., Корнеева О.Н., Палаткина Л.О. Адипокины и сердечно-сосудистые заболевания: патогенетические параллели и терапевтические перспективы // Артериальная гипертензия. — 2011. — Т. 17, № 3. — С. 203–208. / Drapkina O.M., orneeva O.N., Palatkina L.O. Adipokines and cardiovascular diseases: pathogenic parallels and therapeutic perspectives // Arte-rial Hypertension [Arterialnaya Gipertenziya]. — 2011. — Vol. 17, № 3. — P. 203–208 [Russian].
3. Apovian C.M., Gokce N. Obesity and cardiovascular disease // Circulation. — 2012. — Vol. 125, № 9. — P. 1178–1182.
4. Драпкина О.М., Чапаркина С.О. Взаимосвязь метаболического синдрома, асептического воспаления и дисфункции эндотелия // Рос. мед. вести. — 2007. — Т. 12, № 3. — C. 67–76. / Drapkina O.M., Chaparkina S.O. Association of metabolic syndrome, aseptic inlammation and endothelial dysfunction // Russian Medical News [Rossiyskiye Meditsinskiye Vesti]. — 2007. — Vol. 12, № 3. — P. 67–76 [Russian].
5. Lavie C.J., Milani R.V., Ventura H.O. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss // J. Am. Coll. Cardiol. — 2009. — Vol. 53, № 21. — P. 1925–1932.
6. Gregor M.F., Hotamisligil G.S. Inlammatory mechanisms in obesity // Annu. Rev. Immunol. — 2011. — Vol. 29. — P. 415–445.
7. Sun K., Kusminski C.M., Scherer P.E. Adipose tissue remodeling and obesity // J. Clin. Invest. 2011. — Vol. 121, № 6. — P. 2094–2101.
8. Cancello R., Henegar C., Viguerie N. et al. Reduction of macrophage iniltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss // Diabetes. — 2005. — Vol. 54, № 8. — P. 2277–2286.
9. Huber J., Kiefer F.W., Zeyda M. et al. CC chemokine and CC chemokine receptor proiles in visceral and subcutaneous adipose tissue are altered in human obesity // J. Clin. Endocrinol. Metab. — 2008. — Vol. 93, № 8. — P. 3215–3221.
10. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Jr. Obesity is associated with macrophage accumulation in adipose tissue // J. Clin. Invest. — 2003. — Vol. 112, № 12. — P. 1796–1808.
11. Nishimura S., Manabe I., Nagasaki M. et al. In vivo imaging in mice reveals local cell dynamics and inlammation in obese adipose tissue // J. Clin. Invest. — 2008. — Vol. 118, № 2. — P. 710–721.
12. Christiansen T., Paulsen S.K., Bruun J.M., Pedersen S.B., Richelsen B. Exercise-training versus diet- induced weight-loss on metabolic risk factors and inlammatory markers in obese subjects. A 12-week randomized intervention-study // Am. J. Physiol. Endocrinol. Metab. — 2010. — Vol. 298, № 4. — P. 824–831.
13. Cancello R., Tordjman J., Poitou C. et al. Increased iniltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity // Diabetes. — 2006. — Vol. 55, № 6. — P. 1554–1561.
14. Bastard J.P., Maachi M., Lagathu C. et al. Recent advances in the relationship between obesity, inlammation, and insulin resistance // Eur. Cytokine Netw. — 2006. — Vol. 17, № 1. — P. 4–12.
15. Lumeng C.N., Bodzin J.L., Saltiel A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization // J. Clin. Invest. — 2007. — Vol. 117, № 1. — P. 175–184.
16. Lumeng C.N., Deyoung S.M., Bodzin J.L., Saltiel A.R. Increased inlammatory properties of adipose tissue macrophages recruited during diet- induced obesity. Diabetes. — 2007. — Vol. 56, № 1. — P. 16–23.
17. Ruan H., Lodisch H.F. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis faktor-alpha // Cytokine Growth Factor Rev. — 2003. — Vol. 14, № 5. — P. 447–455.
18. Hotamisligil G.S. Inlammatory pathways and insulin action // Int. J. Obes. Relat. Metab. Disord. — 2003. — Vol. 27, suppl. 3. — P. 553–555.
19. Fernandez-Real J.M., Ricart W. Insulin resistance and chronic cardiovascular inlammatory syndrome // Endocr. Rev. — 2003. — Vol. 24, № 3. — P. 278–301.
20. Ruan H., Miles P.D., Ladd C. M. Proiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor — alpha: implications for insulin resistance // Diabetes. — 2002. — Vol. 51, № 11. — P. 3176–3188.
21. Bahceci M., Gokalp D., Bahceci S. et al. The correlation between adiposity and adiponectin, tumor necrosis factor alpha, interleukin-6 and high sensitivity C-reactive protein levels. Is adipocyte size associated with inlammation in adults? // J. Endocrinol. Invest. — 2007. — Vol. 30, № 3. — Р. 210–214.
22. De Alvaro C., Teruel T., Hernandez R., Lorenzo M. Tumor necrosis factor alpha produced insulin resistance in sceletal muscle by activation of inhibitor kappaB-kinase in ap38 MARK-dependant manner // J. Biol. Chem. — 2004. — Vol. 279, № 17. — P. 17070–17078.
23. Vozarova B., Weyer C., Hanson K., Tataranni P.A., Bogardus C., Pratley R.E. Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion // Obes. Res. — 2001. — Vol. 9, № 7. — P. 414–417.
24. Carey A.L., Bruce C.R., Sacchetti M. et al. Interleukin-6 and tumor necrosis factor — alpha are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness // Diabetologia. — 2004. — Vol. 47, № 6. — P. 1029–1037.
25. Cai D., Yuan M., Frantz D.F. et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-βand NF-кB // Nat. Med. — 2005. — Vol. 11, № 2. — P. 183–190.
26. Febbraio M.A., Pedersen B.K. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles // FASEB J. — 2002. — Vol. 16, № 11. — P. 1335–1347.
27. Zhu W., Cheng K.K., Vanhoutte P.M., Lam K.S., Xu A. Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention // Clin. Sci. (Lond). — 2008. — Vol. 114, № 5. — P. 361–374.
28. Fantuzzi G. Adipose tissue, adipokines, and inlammation // J. Allergy Clin. Immunol. — 2005. — Vol. 115, № 5. — P. 911–919.
29. Aprahamian T.R., Sam F. Adiponectin in cardiovascular inlammation and obesity // Int. J. Inlam. — 2011. — Vol. 31, № 2. — P. 167–73.
30. Zhang H., Park Y., Zhang C. Coronary and aortic endothelial function affected by feedback between adiponectin and tumor necrosis factor alpha in type 2 diabetic mice // Arterioscler. Thromb. Vasc. Biol. — 2010. — Vol. 30, № 11. — P. 2156–2163.
31. Park P.H., McMullen M.R., Huang H., Thakur V., Nagy L.E. Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-alpha (TNF-alpha) expression via ERK1/2 activation and Egr-1 expression: role of TNF-alpha in adiponectin-stimulated interleukin-10 production // J. Biol. Chem. — 2007. — Vol. 282, № 30. — P. 21695–21703.
32. Lovren F., Pan Y., Quan A. et al. Adiponectin primes human monocytes into alternative anti-inlammatory M2 macrophages // Am. J. Physiol. Heart Circ. Physiol. — 2010. — Vol. 299, № 3. — P. 656–663.
33. Wulster-Radcliffe M.C., Ajuwon K.M., Wang J., Christian J.A., Spurlock M.E. Adiponectin differentially regulates cytokines in porcine macrophages // Biochem. Biophys. Res. Commun. 2004. — Vol. 316, № 3. — P. 924–929.
34. Yamaguchi N., Argueta J.G., Masuhiro Y. et al. Adiponectin inhibits Toll-like receptor family-induced signalling // FEBS Lett. — 2005. — Vol. 579, № 30. — P. 6821–6826.
35. Devaraj S., Torok N., Dasu M.R., Samols D., Jialal I. Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-tissue-vascular loop // Arterioscler. Thromb. Vasc. Biol. — 2008. — Vol. 28, № 7. — P. 1368–1374.
36. Xu Y., Zhang C., Wang N. et al. Adiponectin inhibits lymphotoxin-beta receptor-mediated NF-KappaB signaling in human umbilical vein endothelial cells // Biochem. Biophys. Res. Commun. — 2010. — Vol. 404, № 4. — P. 1060–1064.
37. Jin С., Henao-Mejia J., Flavell R.A. Innate immune receptors: key regulators of metabolic disease progression // Cell Metab. — 2013. — Vol. 17, № 6. — P. 873–82.
38. Lee J. Adipose tissue macrophages in the development of obesity-induced inlammation, insulin resistance and type 2 diabetes // Arch. Pharm. Res. — 2013. — Vol. 36, № 2. — P. 208–222.
39. Dandona P., Aljada A., Chaudhuri A., Mohanty P., Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inlammation // Circulation. —2005. — Vol. 111, № 11. — P. 1448–54.
40. Dandona P., Ghanim H., Chaudhuri A. et al. Macronutrient intake induces oxidative and inlammatory stress: potential relevance to atherosclerosis and insulin resistance // Exp. Mol. Med. — 2010. — Vol. 42, № 4. — P. 245–253.
41. Gaesser G.A., Angadi S.S., Ryan D.M. et al. Lifestyle measures to reduce inlammation // Am. J. Lifestyle Med. — 2012. — Vol. 6, № 1. — P. 4–13.
42. Maury E., Brichard S.M. Adipokine dysregulation, adipose tissue inlammation and metabolic syndrome // Mol. Cell. Endocrinol. — 2010. — Vol. 314, № 1. — P. 1–16.
43. Kusminski C.M., McTernan P.G., Kumar S. Role of resistin in obesity, insulin resistance and Type II diabetes // Clin. Sci. (Lond). — 2005. — Vol. 109, № 3. — P. 243–256.
44. Tilg H., Moschen A.R. Adipocytokines: mediators linking adipose tissue, inlammation and immunity // Nat. Rev. Immunol. — 2006. — Vol. 6, № 10. — P. 772–83.
45. Kusminski C.M., Scherer P.E. The road from discovery to clinic: adiponectin as a biomarker of metabolic status // Clin. Pharmacol. Ther. — 2009. — Vol. 86, № 8. — P. 592–595.
46. Jae S.Y., Fernhall B., Heffernan K.S. et al. Effects of life-style modiications on C-reactive protein: contribution of weight loss and improved aerobic capacity // Metab. Clin. Experiment. — 2006. — Vol. 55, № 6. — P. 825–831.
47. Luo N., Liu J., Hong Chung B. et al. Macrophage adiponectin expression improves insulin sensitivity and protects against inlammation and atherosclerosis // Diabetes. — 2010. — Vol. 59, № 4. — P. 791–799.
48. Kim J.Y., van de Wall E., Laplante M. et al. Obesityassociated improvements in metabolic proile through expansion of adipose tissue // J. Clin. Invest. — 2007. — Vol. 117, № 9. — P. 2621–2637.
49. Saunders T.J., Palombella A., McGuire K. A. et al. Acute exercise increases adiponectin levels in abdominally obese men // J. Nutrition Metab. — 2012. — Vol. 2012. — ID: 148729.
50. Racil G., Ben Ounis O., Hammouda O. et al. Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females // Eur. J. Appl. Physiol. — 2013. — Vol. 113, № 10. — Р. 2531–2540.
51. Березина A.B., Беляева О.Д., Беркович Е.А. и др. Качество жизни у больных абдоминальным ожирением при снижении веса тела с помощью диеты и физических тренировок // Профилакт. клинич. мед. — 2011. — Т. 1 (39), № 2. — С. 23–30. / Berezina A.V., Belyaeva O.D., Berkovich E.A. et al. Quality of life in patients with abdominal obesity while weight loss with help of diet and physical exercise // Preventive and Clinical Medicine [Proilakticheskaya i Klinicheskaya Meditsina]. — 2011. — Vol. 1 (39), № 2. — P. 23–30 [Russian].
52. Березина A.B. Физическая активность и факторы риска сердечно-сосудистых заболеваний у больных абдоминальным ожирением // Вестн. Рос. Академии естественных наук. —2011. — Т. 15, № 3. — С. 89–94. / Berezina A.V. Physical activity and cardiovascular risk factors in patients with abdominal obesity // Herald of the Russian Academy of Natural Sciences [Vestnik Rossiyskoy Akademii Estestvennykh Nauk]. — 2011. — Vol. 15, № 3. — P. 89–94 [Russian].
53. Hulver M.W., Zheng D., Tanner C.J. et al. Adiponectin is not altered with exercise training despite enhanced insulin action // Am. С. Physiol. Endocrinol. Metab. — 2002. — Vol. 283, № 4. — P. 861–865.
54. Ryan A.S., Nicklas B.J., Berman D.M., Elahi D. Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women // Int. J. Obes. Relat. Metab. Disord. — 2003. — Vol. 27, № 9. — P. 1066–1071.
55. Yokoyama H., Emoto M., Araki T. et al. Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in type 2 diabetes // Diabetes Care. — 2004. — Vol. 27, № 7. — P. 1756–1758.
56. Nassis G.P., Papantakou K., Skenderi K. et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inlammatory markers in overweight and obese girls // Metabolism. — 2005. — Vol. 54, № 11. — P. 1472–1479.
57. Moghadasi M., Mohebbi H., Rahmani-Nia F. et al. Effects of short-term lifestyle activity modiication on adiponectin mRNA expression and plasma concentrations // Eur. J. Sport Sci. — 2013. — Vol. 13, № 4. — P. 378–385.
Review
For citations:
Kryukov N.N., Ginzburg M.M., Kiseleva E.V. UP-TO-DATE VIEW AT THE ROLE OF ASEPTIC INFLAMMATION OF ADIPOSE TISSUE IN THE GENESIS OF OBESITY AND METABOLIC SYNDROME. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2013;19(4):305-310. (In Russ.) https://doi.org/10.18705/1607-419X-2013-19-4-
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