Modern conception about immune system role in the gestosis development
https://doi.org/10.18705/1607-419X-2006-12-1-32-36
Abstract
All at the clinical manifestations ol preeclampsia could be attributed to the endothelial cell dysfunction leading to end-organ damage and hypoperfusion. Preeclampsia is a result immune maladaptation. The candidates mediators of immune maladaptation in preeclampsia include cytokines (especially tumor necrosis factor, (TNF-a) and interleukin-2 and IL-6). In addition a lower level of messenger RNA for HLA-G has been described in the trophoblast cells of preeclamptic patients. Increased syncitiotrophoblast shedding as a consequence of placental apoptosis may contribute to endothelial dysfunction. The aim of this review is to summarize the current understanding of the pathogenesis of preeclampsia with special emphasis on recent discoveries which support the notion that immune maladaptation plays an important role in the pathogenesis of preeclampsia.
About the Author
N. .. Tapilskaya
Санкт-Петербургская Государственная педиатрическая медицинская академия
Russian Federation
Russian Federation
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Review
For citations:
Tapilskaya N... Modern conception about immune system role in the gestosis development. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2006;12(1):32-36. (In Russ.) https://doi.org/10.18705/1607-419X-2006-12-1-32-36
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