HEART RATE VARIABILITY AND ENDOTHELIAL FUNCTION IN SUBJECTS WITH HYPERTENSION AND ITS ASSOCIATION WITH CORONARY HEART DISEASE AND TYPE 2 DIABETES MELLITUS
https://doi.org/10.18705/1607-419X-2013-19-2-178-183
Abstract
and their relationship to nitric oxide production by endothelium.
Design and methods. The study involved 141 patients with hypertension, including isolated hypertension, and associated with coronary heart disease and type 2 diabetes mellitus. Methods of investigation included the evaluation of clinical and conventional instrumentation and laboratory parameters with the additional study of heart rate variability. To assess endothelial function we determined the level of the final stable metabolites of nitric oxide: nitrite and nitrate anions (NO2 - and NO3 -) in blood plasma.
Results and conclusions. According to the analysis of heart rate variability we found apparent disturbances of heart rhythm regulation in hypertensive patients: decreased overall heart rate variability, decreased amplitude of parasympathetic, sympathetic and humoral waves, reduced proportion of sympathetic, parasympathetic waves and increase of humoral waves. Co-existing diabetes mellitus led to more apparent disturbances of autonomic regulation of heart rhythm. High heart rate and low heart rate variability in hypertensive patients are associated with an increase of the final metabolites of nitric oxide in the blood plasma.
About the Authors
E. A. Grigoricheva
Clinic of Chelyabinsk State Medical Academy, Chelyabinsk
Russian Federation
Russian Federation
Corresponding author: Clinic of Chelyabinsk State Medical Academy, 2 Cherkasskaya st., Chelyabinsk, Russia, 454086. Phone: 8 (905) 830–73–18. Fax: 8 (351) 721–82–55. E-mail: lenaqriq@rambler.ru (Elena A. Grigirocheva, MD, PhD, Professor, the Head of the Department of Functional Diagnostics at Chelyabinsk State Medical Academy Clinic).
I. Y. Melnikov
Clinic of Chelyabinsk State Medical Academy, Chelyabinsk
Russian Federation
Russian Federation
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For citations:
Grigoricheva E.A., Melnikov I.Y. HEART RATE VARIABILITY AND ENDOTHELIAL FUNCTION IN SUBJECTS WITH HYPERTENSION AND ITS ASSOCIATION WITH CORONARY HEART DISEASE AND TYPE 2 DIABETES MELLITUS. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2013;19(2):178-183. (In Russ.) https://doi.org/10.18705/1607-419X-2013-19-2-178-183
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