Matrix metalloproteinases and cardiovascular diseases
https://doi.org/10.18705/1607-419X-2009-15-5-532-538
Abstract
The paper reviews the role of matrix metalloproteinases of proteolytic system that perform a great variety of function and control almost all biological processes. According to the classification all proteases are divided into four families serine, cysteine, aspartate and metalloproteinases (last also called matrix metalloproteinases (MMP)). Up to now 28 MMP are known (from MMP-1 to MMP-28). Based on structural features and substrate specificity MMP family was divided into identified 4 subfamilies: collagenases, gelatinases. stromelizines and unclassified MMP. Study of MMP family in cardiology significantly expands the understanding of the pathogenetic mechanisms of cardiovascular diseases and demonstrates different MMPs functions: stromelizine MMP-3, collagenase - MMP-8, gelatinase - MMP-9. It is assumed that MMP-3 and MMP-9 play an important role in acute myocardial infarction, unstable angina, rehabilitation after a heart attack, left ventricular remodeling. There are data of special role of MMP-3, MMP-9 gene polymorphism associated with susceptibility to cardiovascular disease, atherosclerosis of the arteries, heart attack, aneurysm of the aorta. However, role of MMP-2, MMP-7 and unclassified MMPs in cardiac pathology is not well investigated and remains controversial.
About the Authors
A. A. Tourna
FGUZ Clinical Hospital № 83 FMBA, Moscow, Russia
Russian Federation
Russian Federation
R. T. Toguzov
GOU VPO RGMU FUB Department of Clinical Laboratory Diagnostics, Moscow, Russia
Russian Federation
Russian Federation
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For citations:
Tourna A.A., Toguzov R.T. Matrix metalloproteinases and cardiovascular diseases. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2009;15(5):532-538. (In Russ.) https://doi.org/10.18705/1607-419X-2009-15-5-532-538
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