Combination therapy with diuretic and different calcium antagonists in hypertensive patients: The comparison of antihypertensive and hemodynamic effects
https://doi.org/10.18705/1607-419X-2009-15-5-559-564
Abstract
54 patients 42-65 years old with uncomplicated hypertension (stage 2) were studied. The 24-hour blood pressure (ВР) monitoring and doppler-echocardiograpy were performed at baseline and after 16 weeks of treatment. Patients were randomized into 2 groups. In the 1st group patients received combination indapamide with verapamil retard, and in 2nd group, combination of indapamide with amlodipine. The circadian rhythm of BP profile was normalized in 83,9 % of patients in 1st group and in 78,6 % of patients in the 2nd group. In the 1st group, the combination therapy is more effective in patients with diastolic left ventricular dysfunction (DDLV) type I, non-dipper profile of circadian rhythm of BP, and with a hyperkinetic type of circulation. In the 2nd group, combination therapy was effective in patients with DDLV type 2-3 and with a hypokinetic type of circulation.
About the Authors
B. G. Iskenderov
Penza Advanced Training Institute for Doctors, Penza, Russia
Russian Federation
Russian Federation
E. V. Gridneva
Penza Advanced Training Institute for Doctors, Penza, Russia
Russian Federation
Russian Federation
O. N. Sisina
Penza Advanced Training Institute for Doctors, Penza, Russia
Russian Federation
Russian Federation
S. V. Saushkina
Penza Advanced Training Institute for Doctors, Penza, Russia
Russian Federation
Russian Federation
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Review
For citations:
Iskenderov B.G., Gridneva E.V., Sisina O.N., Saushkina S.V. Combination therapy with diuretic and different calcium antagonists in hypertensive patients: The comparison of antihypertensive and hemodynamic effects. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2009;15(5):559-564. (In Russ.) https://doi.org/10.18705/1607-419X-2009-15-5-559-564
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