Diagnostic value of assessment of microcirculation and of pressor response to cold stressor test in patients with coronary artery disease

62 patients with coronary heart disease (CHD), II-III functional class of angina pectoris were observed during rest and stress cold exposure conditions (hand dipping in 4°C water). 75 % of patients had concomitant hypertension. Finger microcirculation flow (FMCF) was measured by laser doppler flowmetry (LDF) method. According to the results of the cold test and systolic blood pressure (SBP) response normotensive patients were divided into 3 groups: 1nd group included patients with normal tonic type of reaction (SBP increase for 0-10 mmHg); 2nd group - with moderate hypertensive reaction (SBP increase for 10-20 mmHg); 3nd group - with marked hypertensive reaction (SBP increase for more than 20 mmHg). The changes in FMCF, hand temperature (HT), finger temperature (FT) and cardiovascular system indices (BP and heart rate (HR)) were assessed. The 3'1 group was found to be different from the others by the lowest FMCF at rest (24,1 ± 3,2 ml/100 g/min.). At the same time FMCF decline during cooling was lower than in the others groups (21,8 ± 3,1 ml/100 g/min.). as well as was FMCF increase (15,4 ± 2,58 ml/100 g/min.) after the test. This testifies the increased sympathetic activity. The local cold test enables establishing the BP response type in normotensivc subjects with CHD and assessment of FMCF changes.

coronary heart disease, hypertension, local cold test, microcirculatory flow, laser-doppler flowmetry

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