Dysregulation of circadian blood pressure rhythm and patho-genesis of cognitive dysfunction in patients with metabolic syndrome
https://doi.org/10.18705/1607-419X-2010-16-4-356-361
Abstract
Objective. To estimate the relationship between circadian blood pressure rhythm disorder and changes in cerebral perfusion and development of cognitive dysfunction in patients with metabolic syndrome (MetS). Material and methods. 52 patients with MetS were involved. All patients were examined by perfusion brain SPECT with99mTc-HMPAO and comprehensive neuropsychological testing. Results. The results of Brain SPECT showed that cerebral perfusion was significantly decreased in MetS patients in comparison with control group. Relationship between indices of 24-hours blood pressure monitoring, cerebral perfusion and cognitive function was found. Conclusions. Our results suggest that patients with MetS have cognitive disorder, and one of its pathogenetic mechanism is the decrease in brain perfusion related to the circadian blood pressure rhythm disorder.
About the Authors
N. Yu. Efimova
Institute of Cardiology, Tomsk, Russia
Russian Federation
Russian Federation
V. I. Chernov
Institute of Cardiology, Tomsk, Russia
Russian Federation
Russian Federation
I. Yu. Efimova
Institute of Cardiology, Tomsk, Russia
Russian Federation
Russian Federation
Yu. B. Lishmanov
Siberian Medical University, Tomsk, Russia
Russian Federation
Russian Federation
E. M. Idrisova
Institute of Cardiology, Tomsk, Russia
Russian Federation
Russian Federation
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Review
For citations:
Efimova N.Yu., Chernov V.I., Efimova I.Yu., Lishmanov Yu.B., Idrisova E.M. Dysregulation of circadian blood pressure rhythm and patho-genesis of cognitive dysfunction in patients with metabolic syndrome. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(4):356-361. (In Russ.) https://doi.org/10.18705/1607-419X-2010-16-4-356-361
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