Autonomic cardiac rhythm regulation in pregnant woman with preeclampsia depending on sodium metabolism gene polymorphism
https://doi.org/10.18705/1607-419X-2010--6-
Abstract
Objective. To investigate the possible association between autonomic cardiac rhythm regulation and the polymorphism Arg389Gly of beta 1-adrenergic receptor gene (ADRB1) and -381T/C natriuretic peptide precursor B (NPPB) in pregnant women with preeclampsia <http://www.ncbi.nlm.nih.gov/pubmed/18326281>. Design and methods. Seventy-nine patients with preeclampsia and 32 non-hypertensive pregnant women in third trimester were included. Frequency domain parameters nHF (normalized high frequency), nLF (normalized low frequency) and LF/HF ratio were obtained by spectral heart rate variability analysis. Non-invasive cardiac reflex test was performed. The polymorphism Arg389Gly of gene ADRB1 and -381T/C NPPB were genotyped by using polymerase chain reaction. Results. The Arg/Arg genotype of the Arg389Gly polymorphism was significantly increased in women who developed preeclampsia (p < 0,05). Patients with preeclampsia were characterized by a significantly reduced cardiac vagal control and lower autonomic reactivity in the low frequency band compared to healthy pregnant woman (p < 0,05). Individuals with preeclampsia who are homozygous for the Arg389 allele of the ADRB1 and NPPB C allele carriers have the most attenuated autonomic reactivity in the LF band of cardiac rhythm spectrum (p < 0,05). Conclusions. Autonomic cardiac rhythm regulation <http://www.ncbi.nlm.nih.gov/pubmed/19055010> <http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=19055010>in pregnant women with <http://www.ncbi.nlm.nih.gov/pubmed/18326281>preeclampsia depends on polymorphism of sodium metabolism genes.
About the Authors
O. V. Radkov
Tver State Medical Academy, Tver
Russian Federation
Russian Federation
M. N. Kalinkin
Tver State Medical Academy, Tver
Russian Federation
Russian Federation
V. V. Zavarin
Tver State Medical Academy, Tver
Russian Federation
Russian Federation
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Review
For citations:
Radkov O.V., Kalinkin M.N., Zavarin V.V. Autonomic cardiac rhythm regulation in pregnant woman with preeclampsia depending on sodium metabolism gene polymorphism. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(6):565-568. (In Russ.) https://doi.org/10.18705/1607-419X-2010--6-
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