Matrix metalloproteinase activity in patients with ascending aortic aneurysm of different etiology
https://doi.org/10.18705/1607-419X-2010--6-
Abstract
Objective. To study the impact of matrix metalloproteinases (MMP) and extracellular matrix proteins on the ascending aorta structural changes in patients with ascending aortic aneurysms of different etiology. Design and methods. 32 patients were included: 26 patients with ascending aortic aneurysm and 6 controls. Both the content and activity of MMP-2, -9 were estimated in the intraoperative biopsies together with the amount of fibrillin, elastin and collagen. Results and conclusion. The development of ascending aortic aneurysm is associated with increased MMP activity. The ascending aortic dilatation in bicuspid aortic valve is associated with increased MMP-2, -9 and collagen/elastin ratio in aortic tissue.
About the Authors
O. B. Irtyuga
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
I. V. Voronkina
Research Institute of Experimental Medicine, St Petersburg
Russian Federation
Russian Federation
L. V. Smagina
Research Institute of Experimental Medicine, St Petersburg
Russian Federation
Russian Federation
V. E. Uspensky
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
N. V. Tsoy
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
M. L. Gordeev
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
O. M. Moiseeva
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Irtyuga O.B., Voronkina I.V., Smagina L.V., Uspensky V.E., Tsoy N.V., Gordeev M.L., Moiseeva O.M. Matrix metalloproteinase activity in patients with ascending aortic aneurysm of different etiology. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(6):587-591. (In Russ.) https://doi.org/10.18705/1607-419X-2010--6-
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