Associationbetween left ventricular myocardium massand parameters of clinical, ambulatory andcentral blood pressure in young men

Objective. To study the association between left ventricular myocardium mass (LVM) and office, 24-hour ambulatory blood pressure (BP), and pulse wave velocity (PWV) in young men aged 18-25 years old. Design and methods. 192 men 18-25 years old (mean age 21,0 ± 2,1 years), who showed a rise in BP at casual measurements, were included. Office and 24-hour ambulatory BP were rechecked, applanation tonometry of radial artery wall stiffness with the use of the transfer function of distal (peripheral) PWV into the central one was performed. Based on echocardiography left ventricular mass index (LVMI) and left ventricular wall thickness (LVWT) ratio, disproportionality index (DI) as the ratio between the studied LVM and the normal one were measured. Spearman analysis was performed for assessing the correlation between hemodynamic parameters and LV characteristics. The correlation at p < 0.05 was considered valid. Results. In the studied group a stronger correlation was seen between LVM index and 24-hour ambulatory BP and PWV parameters rather than for office BP. The correlation was stronger between LVM index and systolic BP (SBP, r = 0,36, p < 0,0001) than with central BP (r = 0,25, p < 0,0001), but correlation coefficient was lower for the daytime PP than for the central PP (r = 0,27 and r = 0,30 respectively, p < 0,0001). DI stronger correlated with SBP, measured by 24-hour ambulatory monitoring (r = 0,20, p = 0,003); LVWT ratio - with office (r = 0,34, p = 0,0001), 24-hour ambulatory (r = 0,33, p < 0,0001) and daytime SBP (r = 0,33, p < 0,0001). There is no correlation between central and peripheral BP and LVMI, however a weak correlation with the reflection wave is seen in young men with sustained hypertension (n = 114). Conclusions. In young hypertensive males at the age of 18-25 years old, the level of central BP does not have any clear advantages in predicting changes in LV structure, unlike the 24-hour ambulatory BP that showed a great importance in diagnosing hypertension in young men.

central blood pressure, left ventricular mass in young men, hypertension in young men, 24-hour blood pressure monitoring, central pulse wave

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