Impact of endothelial nitric oxide synthase gene polymorphism 4a4b on the cardiovascular system in patients with clinical thyrotoxicosis of Graves' disease
https://doi.org/10.18705/1607-419X-2010--2-
Abstract
Background. Nitric oxide synthesized by endothelial nitric oxide synthase plays an important role in endothelial function regulation as well as in blood pressure and heart rate control. Objective. To assess the association between eNOS gene polymorphism intron 4a/4b and hypertension development, tachycardia in patients with clinical thyrotoxicosis. Design and methods. The eNOS gene polymorphisms were examined by polymerase chain reaction. We compared eNOS gene polymorphism 4a4b in 164 patients with clinical thyrotoxicosis. All patients we divided into three groups matching by sex, age, level thyroid hormones: group 1 included patients with eNOS 4b4b polymorphism (n = 111), group 2 - patients with eNOS 4a4b polymorphism (n = 46), group 3 - patients with eNOS 4a4a polymorphism (n = 7). Blood pressure and heart rate were assessed before and after 3-week treatment with β-blocker and angiotensin converting enzyme inhibitors. Result. The eNOS 4a4b polymorphism gene correlates with the blood pressure level and heart rate. Before treatment blood pressure and heart rate were significantly higher in group 1 than in group 3. After treatment blood pressure and heart rate were significantly lower in group 3 in comparison with groups 1 and 2. Conclusion. Our results demonstrate that eNOS polymorphism allele b predisposes to the development of endothelial dysfunction.
About the Authors
D. A. Popkova
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
A. U. Babenko
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Popkova D.A., Babenko A.U. Impact of endothelial nitric oxide synthase gene polymorphism 4a4b on the cardiovascular system in patients with clinical thyrotoxicosis of Graves' disease. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(2):176-180. (In Russ.) https://doi.org/10.18705/1607-419X-2010--2-
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