Structural and functional remodelling of myocardium and arteries and its relation to activity of blood metalloproteinases in hypertensive patients
https://doi.org/10.18705/1607-419X-2010--2-
Abstract
Objective. To investigate relationship between blood matrix metalloproteinase-1 (ММР-1) and its tissue inhibitor (TIMP-1) levels and clinical data, myocardial mass and diastolic left ventricular dysfunction, circadian blood pressure (BP) indices in hypertensive patients with paroxysmal atrial fibrillation. Design and methods. ММР-1 and TIMP-1 levels by hardphase immunoenzyme analysis were defined in 39 hypertensive patients with paroxysmal atrial fibrillation, and the correlation with the main parameters of echocardiography (including tissue echocardiography) and circadian BP indices was assessed. Results and conclusions. Blood TIMP-1 level positively correlates with pulse BP, its variability, and systolic BP variability that can indirectly indicate the existence of relation between blood TIMP-1 level and the increase of arterial rigidity due to the collagen uptake. Increase of MMP-1 blood level positively associates with the reduction in load index of diastolic BP. We found positive correlation of TIMP-1 levels with thickness of interventricalar septum in diastole. Patients with increased left ventricular (LV) myocardial mass index had significantly higher TIMP-1 level compared to patients with normal myocardial mass index. Patients with concentric and eccentric LV hypertrophy had significantly higher TIMP-1 blood level than patients with LV concentric remodelling and normal geometry that can also indicates an increase of collagen accumulation in myocardium.
About the Authors
F. M. Khezheva
Russian Medical Academy of Postgraduate Education, Cardiology Department, Moscow
Russian Federation
Russian Federation
N. A. Mazur
Russian Medical Academy of Postgraduate Education, Cardiology Department, Moscow
Russian Federation
Russian Federation
V. P. Masenko
Russian Medical Academy of Postgraduate Education, Cardiology Department, Moscow
Russian Federation
Russian Federation
N. V. Shestakova
Russian Medical Academy of Postgraduate Education, Cardiology Department, Moscow
Russian Federation
Russian Federation
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For citations:
Khezheva F.M., Mazur N.A., Masenko V.P., Shestakova N.V. Structural and functional remodelling of myocardium and arteries and its relation to activity of blood metalloproteinases in hypertensive patients. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(2):202-207. (In Russ.) https://doi.org/10.18705/1607-419X-2010--2-
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