Angiotensin converting enzyme inhibitors in patients with coronary artery disease
https://doi.org/10.18705/1607-419X-2011--1 -
Abstract
The article reviews data on angiotensin converting enzyme inhibitors (ACEi) in patients with coronary artery disease (CAD). High risk patients require complex therapy that would lower cardiovascular risk and include desaggregants, hypolipidemic drugs, ACEi and beta-blockers. Renin-angiotensin-aldosterone system (RAAS) blockade is the main therapeutic target in hypertensive patients with CAD. ACEi benefi ts include antihypertensive effects by plasma RAAS blockade and organoprotective effects by tissue RAAS blockade unfolding starting from 3-4 weeks of treatment. These enable us to lower cardiovascular risk including risk of myocardial infarction and stroke, to delay the development of arterial hypertension, chronic heart and renal failure, thus, mediating the prognosis improvement. Conclusion. There is evidence of the benefi cial effects of two ACEi in patients with CAD, they are Perindopril and Ramipril. The article presents the data on clinical trials proving clinical effi ciency of Perindorpil in patients with cardiovascular diseases.
About the Author
O. M. Drapkina
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Drapkina O.M. Angiotensin converting enzyme inhibitors in patients with coronary artery disease. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2011;17(1):79-82. (In Russ.) https://doi.org/10.18705/1607-419X-2011--1 -
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