Improving the efficacy of antihypertensive therapy with the use of fixed-dose combination therapy

To demonstrate the benefits of perindopril 10 mg/indapamide 2,5 mg fixed combination in comparison with other variants of two-component antihypertensive therapy to achieve target blood pressure in association with metabolic neutrality. Design and methods. The study cohort included 60 patients (mean age 61,9 ± 11,7 years) with essential arterial hypertension, treated with two antihypertensive drugs and not achieved target blood pressure (< 140/90 mm Hg). The dynamics of 24-hour blood pressure monitoring results, serum levels of total cholesterol, glucose and potassium were assessed. Also the number of patients, who achieved target systolic (< 140 and < 130 mm Hg in case of diabetes mellitus) and diastolic blood pressure (< 90 and < 80 mm Hg in case of diabetes mellitus) was evaluated. Results. Administration of perindopril 10 mg/indapamide 2,5 mg fixed-dose combination allowed to decrease mean daily systolic and diastolic blood pressure by 18,2 and 18,5 %, respectively, mean nighttime systolic and diastolic blood pressure - by 18,6 and 19,8 %, and velocity of systolic, diastolic blood pressure morning surge. Even the short-term antihypertensive therapy (2 months) with perindopril 10 mg/indapamide 2,5 mg fixed combination resulted in improvement of lipid and carbohydrate metabolism, which can be explained by the fact, that every fifth patient took 2,5 mg indapamide instead of 25 mg hydrochlorothiazide. Conclusions. The substitution of the two-component combination antihypertensive therapy to perindopril 10 mg/indapamide 2,5 mg fixed-dose combination provides additional reduction of systolic and diastolic blood pressure by 29 and 19 mm Hg, respectively, and favorable influences the levels of total cholesterol, fasting glucose and glycosylated hemoglobin.

fixed-dose combination therapy

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