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Артериальная гипертензия

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Коморбидные инсомния и артериальная гипертензия: патогенетические модели и перспективные биомаркеры

https://doi.org/10.18705/1607-419X-2019-25-2-143-157

Полный текст:

Аннотация

В данной обзорной статье описаны основные механизмы возникновения и поддержания коморбидных инсомнии и артериальной гипертензии с учетом актуальных патогенетических сценариев инсомнии, включающих концепцию симпатической активации, нейробиологическую модель инсомнии и трехфакторную модель. Результаты единичных клинических исследований свидетельствуют о взаимосвязи уровней артериального давления с гиперактивацией центральной нервной системы во время сна, характеризуемой по электроэнцефалографической активности в диапазоне β-спектра, и с показателями латентности сна. Тем не менее биологически активные вещества, опосредующие так называемое «нейрогенное воспаление», также играют значимую роль в поддержании гомеостаза при воздействии эндогенных и экзогенных стрессорных факторов. Функции интерлейкина‑6, гамма-аминомасляной кислоты, субстанции Р, мелатонина, серотонина и орексина в норме и в патологии позволяют высказать предположение об их участии в механизмах реализации взаимосвязи инсомнии и артериальной гипертензии. Подчеркивается важность трактовки инсомнии в качестве отдельной нозологической единицы, сопутствующей артериальной гипертензии, и актуальность исследований молекулярных механизмов взаимосвязи инсомнии и артериальной гипертензии с целью определения перспективных терапевтических мишеней и прогностических маркеров при конкретном патогенетическом сценарии.

Об авторах

И. А. Фильченко
Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации, Федеральное государственное бюджетное учреждение науки «Институт эволюционной физиологии и биохимии им. И. М. Сеченова» Российской академии наук, Федеральное государственное бюджетное образовательное учреждение высшего образования «Северо-Западный государственный медицинский университет им. И. И. Мечникова» Министерства здравоохранения Российской Федерации

клинический ординатор кафедры неврологии им. акад. С. Н. Давиденкова

Санкт-Петербург, Россия



Л. С. Коростовцева
Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации
Россия

кандидат медицинских наук, научный сотрудник группы по сомнологии НИЛ артериальной гипертензии Института сердца и сосудов, доцент кафедры кардиологии

ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341.
Тел.: +7(812) 702–37–33.



Н. М. Терещенко
Федеральное государственное бюджетное учреждение науки «Институт эволюционной физиологии и биохимии им. И. М. Сеченова» Российской академии наук

лаборант-исследователь лаборатории сравнительной сомнологии и нейроэндокринологии

Санкт-Петербург, Россия



Ю. В. Свиряев
Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации, Федеральное государственное бюджетное учреждение науки «Институт эволюционной физиологии и биохимии им. И. М. Сеченова» Российской академии наук

доктор медицинских наук, руководитель группы по сомнологии НИЛ артериальной гипертензии Института сердца и сосудов

Санкт-Петербург, Россия



И. А. Вознюк
Государственное бюджетное учреждение «Санкт-Петербургский научно-исследовательский институт скорой помощи имени И. И. Джанелидзе»

доктор медицинских наук, профессор, заместитель директора по научной работе

Санкт-Петербург, Россия



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Для цитирования:


Фильченко И.А., Коростовцева Л.С., Терещенко Н.М., Свиряев Ю.В., Вознюк И.А. Коморбидные инсомния и артериальная гипертензия: патогенетические модели и перспективные биомаркеры. Артериальная гипертензия. 2019;25(2):143-157. https://doi.org/10.18705/1607-419X-2019-25-2-143-157

For citation:


Filchenko I.A., Korostovtseva L.S., Tereshchenko N.M., Sviryaev Y.V., Voznjouk I.A. Comorbid insomnia and arterial hypertension: pathogenetic models and promising biomarkers. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2019;25(2):143-157. (In Russ.) https://doi.org/10.18705/1607-419X-2019-25-2-143-157

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