Multiple sclerosis and vitamin D status
https://doi.org/10.18705/1607-419X-2015-21-2-121-129
Abstract
Multiple sclerosis (MS) is known to be a chronic immune-mediated disease of the central nervous system characterized by lesions predominantly in white matter of the brain and spinal cord and by a chronic progression. It affects mainly young people and leads to their irreversible disability. This fact determines high social and economic significance of MS. A multifactorial nature of MS is suggested by the results of investigation, and vitamin D deficiency is presumed to be a possible risk factor. “Non-classical” effects of vitamin D, including its effect on the immune response, are widely studied in the recent years. This review is devoted to the analysis of clinical and experimental data about the association between vitamin D deficiency and MS. It also discusses the pathogenetic effect of vitamin D and analyzed the need and ways for correction of vitamin D deficiency in MS. In this publication we discuss the possible direction of further research in order to establish the optimal dosage and duration of vitamin D treatment in MS.
About the Authors
T. L. Karonova
Federal North-West Medical Research Centre, St Petersburg, Russia
Pavlov First State Medical University of St. Petersburg, St Petersburg, Russia
Russian Federation
Russian Federation
MD, PhD, DMSc, Head, Scientific Research Laboratory of Clinical Endocrinology of Endocrinology Institute, Federal North-West Medical Research Centre; Assistant Professor, Department of Internal Diseases No 2 with the Course of Endocrinology, Cardiology and Functional Diagnostics with Clinic No 1, Pavlov First State Medical University of St. Petersburg;
I. A. Shmonina
Pavlov First State Medical University of St. Petersburg, St Petersburg, Russia
Russian Federation
Russian Federation
MD, PhD student, Department of Internal Diseases No 2 with the Course of Endocrinology, Cardiology and Functional Diagnostics with Clinic No 1, Pavlov First State Medical University of St. Petersburg;
N. A. Totolyan
Pavlov First State Medical University of St. Petersburg, St Petersburg, Russia
Russian Federation
Russian Federation
MD, PhD, DMSc, Professor, Department of Neurology and Neurosurgery with Clinic, Pavlov First State Medical University of St. Petersburg.
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Karonova T.L., Shmonina I.A., Totolyan N.A. Multiple sclerosis and vitamin D status. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(2):121-129. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-2-121-129
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