Lipid metabolism and cardiovascular diseases in population of St Petersburg citizens with type 2 diabetes mellitus
and different polymorphisms of taqib gene encoding transporter of cholesterol esters

Objective. To assess lipid metabolism and prevalence of cardiovascular diseases in patients with type 2 diabetes mellitus (T2DM) — the bearers of different TaqIB genotypes of the polymorphism of the cholesteryl ester transfer protein (CETP), citizens of St Petersburg. Design and methods. We examined 382 patients, who have not received statin therapy previously, and 187 control individuals. The study included the assessment of clinical data and blood lipid profile analysis, as well as molecular genetic research. Results. The distribution of genotypes and alleles of TaqIB polymorphism of the СETP gene in T2DM patients and control group individuals was comparable (В1 В1 29,6 and 24,3 %, В1 В2 50,8 and 51,9 %, В2 В2 19,6 and 23,8 %, respectively). B1B1 genotype in T2DM patients is associated with the 1,85-fold increase of the risk of stroke (p = 0,012). B1B2 genotype of TaqIB polymorphism of the СEТР gene in healthy individuals is associated with higher triglycerides values, cholesterol of low density lipoproteins, cholesterol of very low density lipoproteins and atherogenicity factor, as compared to lipid profile in T2DM patients (the bearers of B2B2 genotype). Lipid profile was also comparable in subgroups of T2DM patients with different TaqIB genotypes. Conclusions. B1B1 genotype of CETP is associated with 1,85-fold increase of the risk of stroke in T2DM patients. The distribution of genotypes and alleles of TaqIB polymorphism of the СETP gene is comparable in T2DM patients and healthy individuals; and fasting lipid profiles are similar in the bearers of different genotypes of this gene. 

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