Neurophysiological justification of the G. F. Lang hypothesis about the occurrence of essential hypertension
https://doi.org/10.18705/1607-419X-2021-27-5-499-508
Abstract
This article is an analysis of modern data on the morphological, functional and neurochemical organization of the central mechanisms of blood circulation regulation, the violation of which can cause the development of essential hypertension. The data indicating the validity of the hypothesis of G.F. Lang that prolonged emotional stress leads to a violation of the neuronal activity of the hypothalamus structures are presented. The article describes the morphological connections of the hypothalamus with the neurons of the ventrolateral region of the medulla oblongata and the structures of the spinal cord that provide neurogenic vascular tone. The evidence of convergence of axons of neurons of the paraventricular nucleus of the hypothalamus on the preganglionic neurons of the spinal cord is presented. Neurochemical processes in the vasomotor center of the medulla oblongata are considered, morphological changes of preganglionic sympathetic neurons in experimental arterial hypertension are indicated.
Keywords
essential hypertension,
hypothalamus,
vasomotor center,
preganglionic sympathetic neurons,
glutamate
Supporting agencies: The authors declare no conflict of interest.
About the Authors
E. V. Shlyakhto
Almazov National Medical Research Centre; Pavlov University
Eugene V. Shlyakhto, MD, PhD, DSc, Professor, Academician of the Russian Academy of Sciences, General Director
15 Parkhomenko avenue, St Petersburg, 194156
V. A. Tsyrlin
Almazov National Medical Research Centre
Vitaliy A. Tsyrlin, MD, Ph D. DSc, Professor, Chief Researcher, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre
15 Parkhomenko avenue, St Petersburg, 194156
N. V. Kuzmenko
Almazov National Medical Research Centre; Pavlov University
Russian Federation
Russian Federation
Natalia V. Kuzmenko, PhD, Senior Researcher, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre; Researcher, Blood Circulation Biophysics Laboratory
15 Parkhomenko avenue, St Petersburg, 194156
M. G. Pliss
Almazov National Medical Research Centre; Pavlov University
Mikhail G. Pliss, PhD, Head, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre; Head, Blood Circulation Biophysics Laboratory
15 Parkhomenko avenue, St Petersburg, 194156
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Shlyakhto E.V., Tsyrlin V.A., Kuzmenko N.V., Pliss M.G. Neurophysiological justification of the G. F. Lang hypothesis about the occurrence of essential hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2021;27(5):499-508. (In Russ.) https://doi.org/10.18705/1607-419X-2021-27-5-499-508
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