Pathogenetic links between ischemic stroke and sleep-disordered breathing
М. S. Golovkova-Kucheriavaia,
S. N. Yanishevskiy,
М. V. Bochkarev,
L. S. Korostovtseva,
Yu. V. Sviryaev https://doi.org/10.18705/1607-419X-2022-28-3-224-234
Abstract
The paper reviews the pathophysiological links between ischemic stroke and sleep-disordered breathing. We discuss well-known mechanisms, such as intermittent hypoxemia, disturbed sleep structure and fluctuations in intrathoracic pressure, autonomic imbalance, oxidative stress, as well as genetic factors and the role of glymphatic system. The impact of sleep-disordered breathing on the development of various subtypes of stroke (according to the TOAST classification) and the so-called “wake-up stroke” is presented.
Keywords
sleep-disordered breathing,
obstructive sleep apnea,
central sleep apnea,
stroke,
glymphatic system,
genetic polymorphisms
Supporting agencies: The work is supported by the grant of the Russian Science Foundation № 22–25– 20155
About the Authors
М. S. Golovkova-Kucheriavaia
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Mariya S. Golovkova-Kucheriavaia, MD, Researcher, Department for Hypertension, Research Laboratory of Pathogenesis and Therapy of Arterial Hypertension
2 Akkuratova str., St Petersburg, 197341
S. N. Yanishevskiy
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Stanislav N. Yanishevskiy, MD, PhD, DSc, Head, Research Laboratory of Neurology and Neurorehabilitation
St Petersburg
М. V. Bochkarev
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Michael V. Bochkarev, MD, PhD, Senior Researcher, Somnology Laboratory, Research Department for Hypertension
St Petersburg
L. S. Korostovtseva
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Lyudmila S. Korostovtseva, MD, PhD, Senior Researcher, Somnology Laboratory, Research Department for Hypertension
St Petersburg
Yu. V. Sviryaev
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Yuriy V. Sviryaev, MD, PhD, DSc, Head, Somnology Laboratory, Research Department for Hypertension
St Petersburg
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Golovkova-Kucheriavaia М.S., Yanishevskiy S.N., Bochkarev М.V., Korostovtseva L.S., Sviryaev Yu.V. Pathogenetic links between ischemic stroke and sleep-disordered breathing. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2022;28(3):224-234. (In Russ.) https://doi.org/10.18705/1607-419X-2022-28-3-224-234
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