Circulating Maternal Serum Cell Free Fetal DNA Levels for Prediction of Preeclampsia
https://doi.org/10.18705/1607-419X-2025-2480
EDN: VELVEM
Abstract
Objective. To measure the maternal serum cell free fetal DNA (CFFDNA) and establish the relationship between preeclampsia (PE) and maternal serum (CFFDNA) levels. Design and methods. A nested case-control study was carried out on 30 (PE) subjects and 30 matched controls aged 18–40 years old who were submitted at the Ain-S hams University maternity hospital. All subjects had a single viable fetus beyond 20-week gestational age. Upon enrollment, blood samples were collected, and the CFFDNA was subsequently measured in subjects and controls. Results. The CFFDNA level differed significantly between the analyzed groups, showing higher levels in PE diagnosed individuals than in controls. Additionally, the maternal serum CFFDNA level, utilizing an area under the curve of 0,979, predicted PE. Conclusion. Maternal serum cell free DNA can be utilized for PE prediction. The mean levels of CFFDNA correlate with developing maternal complications in PE.
About the Authors
S. A.M. Nassar
Ain Shams University
Egypt
Egypt
Salma Ashraf Mohamed Nassar, MD, Lecturer of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine,
Cairo
A. M.B. El Din
Ain Shams University
Egypt
Egypt
Ahmed Mohamed Bahaa El Din, MD, PhD, DSc, Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine,
Cairo.
M. E.M. Ibrahim
Ain Shams University
Egypt
Egypt
Mohamed El Mandouh Mohamed Ibrahim, MD, PhD, DSc, Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine,
Cairo.
M. M.M. Helmy
Ain Shams University
Egypt
Egypt
Mohamed Mahmoud Mohamed Helmy, MD, Department of Obstetrics and Gynecology, Faculty of Medicine,
Cairo.
M. S. Elsewefy
Ain Shams University
Egypt
Egypt
Mohamed Sameh Elsewefy, MD, Lecturer of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine,
Cairo.
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Review
For citations:
Nassar S.A., El Din A.M., Ibrahim M.E., Helmy M.M., Elsewefy M.S. Circulating Maternal Serum Cell Free Fetal DNA Levels for Prediction of Preeclampsia. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2025;31(1):54-62. https://doi.org/10.18705/1607-419X-2025-2480. EDN: VELVEM
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